DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and Mtrex

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_001029265.1	Gene:	Mtrex / 365668	RGDID:	1305984	Length:	1042	Species:	Rattus norvegicus

Alignment Length:	1067	Identity:	668/1067 - (62%)
Similarity:	820/1067 - (76%)	Gaps:	46/1067 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EELFDCF-DEVTPSVPPPALNQEEK-----PSGSSASKKGNKRQADGTTASKEATSSKGAEGDDK 62
            :|||..| |:.|.:.......::||     |.| .|.|.|  ::.|....|:.|:|     |.:|
  Rat     7 DELFSVFEDDSTTAAGTKKDKEKEKDKWKGPPG-PADKAG--KRLDTRLQSEPASS-----GKNK 63

  Fly    63 GDVTEEPTKRLKQEASTVAVDDDNNADDEP-----TRTLD-IDDSATLEALRTRIVTHLLDAPKS 121
            .|:..|.|                   |||     .|..| |::..:|..|..|:....::..:.
  Rat    64 RDLDVEGT-------------------DEPIFGKKPRIEDSINEDLSLADLMPRVKVQSVETVEG 109

  Fly   122 CTHEVAAHPDQEYIPLKPFSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYA 186
            ||||||...|::||||||..|..||||||:||.|||:||.|:||:|||||||||||||||.||||
  Rat   110 CTHEVALPADEDYIPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYA 174

  Fly   187 IAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRG 251
            ||.:|..|||||:|:|||||||||:||..:||:||||:||||||||:||||:|||||||:|||||
  Rat   175 IALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRG 239

  Fly   252 SEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPC 316
            ||:||||.||:|||||||||.|||||||||:|||||||.|||||||||||||||||:||||||||
  Rat   240 SEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPC 304

  Fly   317 HVVYTDYRPTPLQHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGRHGGIK 381
            ||:||||||||||||||||||||:||:|||.|.|:||||.|||.||.:||:..|||||||.||.|
  Rat   305 HVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTK 369

  Fly   382 GTNAGQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDV 446
                |.:|:||||||||||||.|||||||||||||.||:||.||||||.:|||:|:||||||:|.
  Rat   370 ----GPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFNNAIDC 430

  Fly   447 LTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPART 511
            |::||::|||||:|||||:||||||||||||||||||||||.||||||||||||||||:||||||
  Rat   431 LSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPART 495

  Fly   512 VLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADPIN 576
            ||||..||:|||.||||||||||||:|||||||:||:||||||:|||:||.:|:.:::|.|||:|
  Rat   496 VLFTNARKYDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLN 560

  Fly   577 SAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIAS 641
            ||||||||||||||||||||||||||:||||||:..|:||:.::|:....:.||:.|.:|.|:..
  Rat   561 SAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEENVVI 625

  Fly   642 YHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPLKA 706
            |:.||.||.:.||:..::|.||:|.||||||||||||.....::.||:|:||.|:...:.|..:.
  Rat   626 YYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGEL 690

  Fly   707 EPSVTIDVLLHVSEAAAKTGDTE---PCKPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSADN 768
            :|...::|||..|:.:.|...||   |.||:|:|.|:||||...|::.||::|:|.|.|||..||
  Rat   691 DPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISTVRLYIPKDLRPVDN 755

  Fly   769 RRAVLKTIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHR 833
            |::|||:|||.:||||.|.|:|:|||||.|:|:..:.::..:..||.|:..||||..|.||.::.
  Rat   756 RQSVLKSIQEVQKRFPDGVPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYT 820

  Fly   834 RYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADE 898
            ..:.|..:...::..|.|||.||::|||||||.|||||||:|:....||||.|||||||:|||||
  Rat   821 LCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADE 885

  Fly   899 LLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECK 963
            ||:|||:|||:||||::.||.|||||||..|.|||..|...:|:||||.||:.|:||||||.|.|
  Rat   886 LLLTEMMFNGLFNDLSSEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAK 950

  Fly   964 LDLDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIG 1028
            |::|.:||:..|||.|||||..|..|::|..:|||||:||||||||||||||||||||||:|.||
  Rat   951 LEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIG 1015

  Fly  1029 NTDLENKFSEGIRLLKRDIVFAASLYL 1055
            ||:|||||:|||..:||||||||||||
  Rat  1016 NTELENKFAEGITKIKRDIVFAASLYL 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	643/972 (66%)
		DEAD	154..299	CDD:278688	117/144 (81%)
		HELICc	390..554	CDD:238034	137/163 (84%)
		rRNA_proc-arch	600..853	CDD:289976	111/255 (44%)
		DSHCT	881..1048	CDD:285374	116/166 (70%)
Mtrex	NP_001029265.1	Dob10	94..1042	CDD:226947	637/951 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352871
Domainoid	1	1.000	247	1.000	Domainoid score	I2081
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6257
Inparanoid	1	1.050	1300	1.000	Inparanoid score	I145
OMA	1	1.010	-	-		QHG53687
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	1	1.000	-	-		oto97808
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2451
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810