Protein Alignment Mtr4 and Skiv2l

DIOPT Version :9

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: XP_006255985.1
• Gene: Skiv2l / 294260
• RGDID: 1303059
• Length: 1244
• Species: Rattus norvegicus
• Alignment Length: 1154
• Identity: 398/1154 - (34%)
• Similarity: 584/1154 - (50%)
• Gaps: 184/1154 - (15%)

  Fly     2 DIEELFDCFDEVTPSVPP-------------PA-------LNQEEKPSGSSASKKGNKRQAD--- 43
            :.||..| |::...:|||             ||       |::..:|...|...:|....|.
  Rat   172 EAEEEID-FEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPLDLSGGDEGEGEAAGGPR 235

  Fly    44 GTTASKEATSSKGAEGDDKGDVTEEPTKRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALR 108
            |..||...:|:.........|:       :.:|||||.                    :|||.|:
  Rat   236 GDAASASPSSTPLIRASSLEDL-------VLKEASTVV--------------------STLEPLK 273

  Fly   109 TRIVTHLLDAPKSCTHEVAAHPDQEY--IPLKPFSGV---------PAKEYPFVLDPFQRQAILC 162
            .                    |.||.  :|:...|.|         ||.::.|..|.||:||||.
  Rat   274 P--------------------PPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILH 318

  Fly   163 IDNSQSVLVSAHTSAGKTVVAEYAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGD 227
            ::...||.|:||||||||||||||||.:.....|.|||:|||||||||||:|.:.|.||||:|||
  Rat   319 LEQHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGD 383

  Fly   228 VTINPSASCLIMTTEILRNMLYRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYV 292
            |.::|.||||||||||||:|||.||:::|::.||:|||:||:.|.||||||||.||:||::|..:
  Rat   384 VQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSII 448

  Fly   293 FLSATIPNARQFAEWVCHLHKQPCHVVYTDYRPTPLQHYIF----PAGGDGIHLIVDEKGQFKED 353
            .||||:|||.:||:|:..|.::..:|:.|..||.||:||:|    |.....:.|::|.:|.|...
  Rat   449 LLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTK 513

  Fly   354 NFTTAMAVLANAGEAGKGDQKGRHG---GIK-----GTNAGQTNIF-KIVKMIMERNFAPVIIFS 409
            .:..|:       || |.::..:|.   |.|     |..|....:: .::..:..|...||::|:
  Rat   514 GYYAAV-------EA-KKERMSKHAQTFGAKQPTHQGGPAQDRGVYLALLASLRTRAQLPVVVFT 570

  Fly   410 FSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGG 474
            ||:..|:..|..:..||..|..||..:.......:..|...||:||||.::..|||||:|:||.|
  Rat   571 FSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSG 635

  Fly   475 LLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGR 539
            :||||||.:|:||..||:|.||||||||||:|||||||:|.:.||.||..||.:..|||:|||||
  Rat   636 ILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGR 700

  Fly   540 AGRRGLDDKGIVILMIDEKVSPAVG--RDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLE 602
            |||||||..|.|||:...:| |.:.  ..::.||...:.|.|.|||.|:||||||:.:..|.|::
  Rat   701 AGRRGLDPTGTVILLCKGRV-PEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMK 764

  Fly   603 RSFYQFQNQAALPGLHDQV--EQKTLELNK-LTIKDEHNIA-------SYHHIRSQLDQHGKQFR 657
            |||.:|      |...|..  ||...:|.| |...:|.::.       .|:....:|.:.....:
  Rat   765 RSFSEF------PSRKDSKAHEQALADLTKRLGALEEPDVTGQLADLPEYYSWAEELTETRNMIQ 823

  Fly   658 QWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPLKAEPSVTIDVLLHVSEAA 722
            :.|.:....|..|..||:|.|.........|::|.......||        ..|..||......:
  Rat   824 RRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSR--------VFTTLVLCDKPAVS 880

  Fly   723 AKTGDTEPCKPNERGCMEVV---------PVAHTL-------ITQISS--IRVYFPNDLRSADNR 769
            ....|..|..|:.....::|         |..||:       :..||:  :||...........|
  Rat   881 ENPRDKGPATPDVPHPDDLVGFKLFLPEGPCEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKR 945

  Fly   770 R-----------AVLKTIQE---AKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFE-----K 815
            :           ||...:||   ..:.:|.|||.|:||:|:.:||         ::..|     :
  Rat   946 QQPKFRKDPPLAAVTTAVQELLRLAQAYPAGPPTLDPINDLQLKD---------VAVVEGGLRAR 1001

  Fly   816 RLEE-----HPLHKSPELERIHRRYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMG 875
            :|||     ..:| ||.....:.:.|:::.:||:::.|:. |.:.:|||.:.|...|..|||.:|
  Rat  1002 KLEELIRGAQCVH-SPRFPAQYVKLQERMQIQKEMERLRF-LLSDQSLLLLPEYHQRVEVLRTLG 1064

  Fly   876 YCKPGDVIEFKGRVACELSSADELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATE 940
            |......::..|||||.:|| .|||:||::|:...:.|...:..||||..||........:..:.
  Rat  1065 YVDEAGTVKLAGRVACAMSS-HELLLTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPST 1128

  Fly   941 LSGPLRSMQDLARRIAKVSTECKLDLDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGS 1005
            |...:..::.:|:||.:|...|.|:...:.:|.:....|::||..|.:|..|..:..::...||.
  Rat  1129 LKQGVERVKAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGL 1193

  Fly  1006 IIRCMRRLEELLRQMCQASKTIGNTDLENKFSEGIRLLKRDIVFAASLY 1054
            ::||::||.|:.|.:..|::.:|...|..|......||:||||||||||
  Rat  1194 VVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLY 1242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	374/1042 (36%)
		DEAD	154..299	CDD:278688	94/144 (65%)
		HELICc	390..554	CDD:238034	83/164 (51%)
		rRNA_proc-arch	600..853	CDD:289976	66/304 (22%)
		DSHCT	881..1048	CDD:285374	50/166 (30%)
Skiv2l	XP_006255985.1	TMEM51	<219..277	CDD:291990	18/104 (17%)
		Dob10	288..1242	CDD:226947	364/988 (37%)
		DEAD	312..459	CDD:278688	96/146 (66%)
		HELICc	621..705	CDD:197757	56/83 (67%)
		rRNA_proc-arch	762..1040	CDD:289976	66/301 (22%)
		DSHCT	1070..1236	CDD:285374	50/166 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720