DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and SPAC17H9.02

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_593572.1	Gene:	SPAC17H9.02 / 2542173	PomBaseID:	SPAC17H9.02	Length:	1030	Species:	Schizosaccharomyces pombe

Alignment Length:	1053	Identity:	469/1053 - (44%)
Similarity:	686/1053 - (65%)	Gaps:	63/1053 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ADGTTASKEATSSKGAEGDDKGDV--------TEEPTKRL---KQEASTVAVDDDNNADDEPTR- 94
            ::.:|.||....|:|:......::        |:|..|..   .:|.|.:....|::.:.|..:
pombe     2 SENSTDSKNFQFSEGSRESSNDELKVLLRDTETKEDEKSSFSNSEEESIIENLSDSSVNKEYAKN 66

  Fly    95 TLDIDDSATLEALRTRIVTHLLDAPKS----CTHEVAAHPDQEYIPLKPF--SGVPAKEYPFVLD 153
            :|.:.|:.:    .::.:..||...:.    ..|:|....|.:||||...  |..|||.|||.||
pombe    67 SLKLSDAVS----ESKYLNPLLKDKRHDRSFALHKVVVPDDYDYIPLNKHIPSDPPAKTYPFELD 127

  Fly   154 PFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEF 218
            |||..||.|::..:||||||||||||||:||||||::|..:||||||:|||:|||||:||...||
pombe   128 PFQSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQRVIYTSPIKSLSNQKYRELLSEF 192

  Fly   219 KDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLI 283
            .||||:||||:||||||||||||||||.|||:.||||.|:.||:|||:||||||:||||||||||
pombe   193 GDVGLMTGDVSINPSASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLI 257

  Fly   284 LLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHVVYTDYRPTPLQHYIFPAGGDGIHLIVDEKG 348
            ||||.:|::|||||:|||.|||.|:..:|||||||||||||||||||:|:|.|.|||:::||||.
pombe   258 LLPDAIRFIFLSATLPNALQFARWISEIHKQPCHVVYTDYRPTPLQHFIYPQGADGIYMLVDEKN 322

  Fly   349 QFKEDNFTTAMAVL------ANAGEAGKGDQKGRHGGIKGTNAGQTNIFKIVKMIMERNFAPVII 407
            :||.:||...:.||      .|..::.|..:|            .:::.:|:.|::...:.|:|:
pombe   323 KFKTENFKKVLEVLDHSTRQENYSKSSKKVKK------------SSSLERIINMVLSNRYDPIIV 375

  Fly   408 FSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHH 472
            |.||||:|||.|.|..|||.|..:.|:||.|:|::|::.|:||||.|.|.|.:..||.|||||||
pombe   376 FCFSKKECEINAHQFGKLDLNDTENKELVTEIFDSAINQLSEEDRGLRQFEEMRSLLLRGIGIHH 440

  Fly   473 GGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMA 537
            .||||||||.:||||.|||::.|||||||::||||||||||||..:||.|..|||::||||:||:
pombe   441 SGLLPILKELVEILFQEGLVRILFATETFSIGLNMPARTVLFTKAQKFSGNNFRWLTSGEYMQMS 505

  Fly   538 GRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLE 602
            |||||||:|.||:.|:::|:.:.....|.::.|:||.:||||||:|.|:|||:|:|||:||.:|:
pombe   506 GRAGRRGIDTKGLSIVILDQSIDEQAARCLMNGQADVLNSAFHLSYGMILNLMRIEEISPEDILK 570

  Fly   603 RSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIASYHHIRSQLDQHGKQFRQWITKPQYLL 667
            :|||||||..:||.:.:::.|...|...:.|.:|..:..:|.::.||:::|::.::.:|.|...|
pombe   571 KSFYQFQNMESLPLIKEELMQLKNEETSINIPNETAVKEFHDLKLQLEKYGEEIQKVMTHPDNCL 635

  Fly   668 PFLQPGRLVKVAAGSQEYDWGIVLNFKKQ--DQSRKNPLKAEPSVTIDVLLHVSEAAAKTGDTEP 730
            |:||.|||:::..|...:.||:::|..|:  |.:.:..:....:..:||||.:|..:.......|
pombe   636 PYLQSGRLIQIKLGGIIFPWGVLVNVIKREFDPNTREQVAPHETYVLDVLLPISSNSMSNHKVNP 700

  Fly   731 C-----KPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSADNR----RAVLKTIQEAKKRFPLG 786
            .     :|||....|:|.|..|.:..|||||:|.|.:|.|.:::    |.|.:.|:|.|:
pombe   701 SILVPPRPNETPLYEIVSVLLTAVCNISSIRIYMPRELNSNESKLRAYRRVNEVIEEFKE----- 760

  Fly   787 PPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDKVTLQKQLQDLKAE 851
            .|.|:|::.|:|:.......:..:...|.:|.:.|.:|..:....:..::.|:.|:.|::|:..:
pombe   761 IPYLDPLEHMHIESSTLSLSLRKLEILEPKLFDSPYYKDSKHRAEYHEFRKKLNLRAQIKDISTK 825

  Fly   852 LKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMIFNGVFNDLTAP 916
            :....:::|:.|||.|:|||||:|:|...:||:.|||||||::|.||||:.|:||.|.||.:...
pombe   826 ITNTEAIIQLRELKIRQRVLRRLGFCTLENVIDIKGRVACEITSGDELLLVELIFQGFFNQMPPE 890

  Fly   917 QAVALLSCFVCDEKSSESVKSATELSGPLRSMQ----DLARRIAKVSTECKLDLDADTYVDKFKP 977
            :..|.|||||.::||..|..:..|   |.:.|.    :.|:|||.||.|.||..:...|:.:|||
pombe   891 EIAAALSCFVYEDKSEVSTLNLKE---PFKKMYLTIIEAAKRIATVSLESKLQFNESDYLHQFKP 952

  Fly   978 FLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIGNTDLENKFSEGIRL 1042
            .:|:.|..|..|:||..:|.::.::||||:|..|||:|||:|:..|:..:||.:|:.|.....:.
pombe   953 DIMEPVSLWINGASFQEICIVSKLYEGSIVRTFRRLDELLKQLEHAAIVLGNNELKEKSVLTEQK 1017

  Fly  1043 LKRDIVFAASLYL 1055
            |.|||:|:|||||
pombe  1018 LHRDIIFSASLYL 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	456/991 (46%)
		DEAD	154..299	CDD:278688	108/144 (75%)
		HELICc	390..554	CDD:238034	98/163 (60%)
		rRNA_proc-arch	600..853	CDD:289976	73/263 (28%)
		DSHCT	881..1048	CDD:285374	72/170 (42%)
SPAC17H9.02	NP_593572.1	Dob10	5..1030	CDD:226947	467/1048 (45%)
		DEAD	128..277	CDD:278688	111/148 (75%)
		HELICc	358..522	CDD:238034	98/163 (60%)
		rRNA_proc-arch	568..826	CDD:289976	73/262 (28%)
		DSHCT	855..1023	CDD:285374	72/170 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	238	1.000	Domainoid score	I469
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53687
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	O	PTHR12131
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2451
TreeFam	1	0.960	-	-
	9	8.780