DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and mtr4

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_001342839.1	Gene:	mtr4 / 2541639	PomBaseID:	SPAC6F12.16c	Length:	1117	Species:	Schizosaccharomyces pombe

Alignment Length:	1128	Identity:	583/1128 - (51%)
Similarity:	757/1128 - (67%)	Gaps:	92/1128 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ELFDCFDEVTPSVPPPALNQEEKPSGSSASKKGNKRQADGTTASKEATSSKGAEGDDKGDVTEEP 69
            ||.|.|......| |.:|.:|.|.|.:|.:.:..||......||.:...:|..| ...|: .|..
pombe     5 ELDDAFGVFEGKV-PKSLKEESKNSQNSQNSQKIKRTLTDKNASNQEQGTKKLE-SSVGE-QESA 66

  Fly    70 TKRLKQE------------------------AST--------VAVDD-------DNNADDEPTRT 95
            |||.|.|                        |.|        :|.||       .|..|..|..|
pombe    67 TKRAKIENLKDNQDLIPNNDVNGIHINNSAVADTKHKPKIGDIAADDISNEVSIKNEGDTIPEAT 131

  Fly    96 LDIDDSATLEA-LRTRIVTHLLDAPKSCT-----------HEVAAHPDQEYIPLKPFSG--VPAK 146
              :.||...|| |:......:.:| ||.|           |:|:..|:.:|:|:.....  .||:
pombe   132 --VADSFEQEASLQVAGKVGMTEA-KSSTEEVVELRHQVRHQVSIPPNYDYVPISKHKSPIPPAR 193

  Fly   147 EYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLAAKQRVIYTTPIKALSNQKF 211
            .|||.|||||..:|.||:..:|||||||||||||||||||:|:||..|||||||:|||||||||:
pombe   194 TYPFTLDPFQAVSIACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIYTSPIKALSNQKY 258

  Fly   212 REFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMREVGWVVFDEIHYMRDKERGV 276
            ||...||.||||:||||||||.|:||:|||||||:|||||||:||||.||:||||||||||||||
pombe   259 RELLAEFGDVGLMTGDVTINPDATCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGV 323

  Fly   277 VWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHVVYTDYRPTPLQHYIFPAGGDGIH 341
            |||||:|||||...:||||||||||.|||||:..:|:|||||||||:||||||||:||:|.||||
pombe   324 VWEETIILLPDKSHFVFLSATIPNAMQFAEWITKIHRQPCHVVYTDFRPTPLQHYLFPSGSDGIH 388

  Fly   342 LIVDEKGQFKEDNFTTAM-----------AVLANAGEAGKGDQKGRHGGIKGTNAGQTNIFKIVK 395
            |:||||..|:|:||..||           |.:|..|.|.||  |...||:|    |.::|:||||
pombe   389 LVVDEKSNFREENFQRAMSALMEKQGDDPAAMATKGNAKKG--KTGKGGVK----GPSDIYKIVK 447

  Fly   396 MIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTEEDRRLPQVENV 460
            |||.:|:.|||:|||||::||..|:||:|||.|...|:.||..:||||::.|:|:||.|||:|::
pombe   448 MIMVKNYNPVIVFSFSKRECEALALQMSKLDMNDQTERDLVTTIFNNAVNQLSEKDRELPQIEHI 512

  Fly   461 LPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFTAPRKFDGKKF 525
            ||||||||||||.||||||||.|||||.|||:|.|||||||::||||||:||:||..||||||.|
pombe   513 LPLLRRGIGIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTNVRKFDGKTF 577

  Fly   526 RWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADPINSAFHLTYNMVLNLL 590
            ||||.||||||:||||||||||:||||||||||:.|.|.:.:::|:||.::|||||:|||:||||
pombe   578 RWISGGEYIQMSGRAGRRGLDDRGIVILMIDEKMDPPVAKSMLKGEADRLDSAFHLSYNMILNLL 642

  Fly   591 RVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIASYHHIRSQLDQHGKQ 655
            |||.|:||:||||.|:||||...:|.|..::|:.....:..||.||..:..||.:::||:::...
pombe   643 RVEGISPEFMLERCFFQFQNSLEVPKLEAKLEESQQHYDSFTILDERPLEEYHTLKTQLERYRTD 707

  Fly   656 FRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQ--DQSRKNPLKAEPSVTIDVLLHV 718
            .|..:..|.:.|.|||.||||:|..|::::|||:|:|..|:  .:.:.|....:.|..:..|:.|
pombe   708 VRTVVNHPNFCLSFLQGGRLVRVKVGNEDFDWGVVVNVSKRPLPKGQSNEYLPQESYIVHTLVMV 772

  Fly   719 SEAAAKTG----------DTEPCKPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSADNRRAVL 773
               |:.||          :..|....::|..||||...:.:..|:.|||:.||||:|...:..|.
pombe   773 ---ASDTGPLRIRSGHLPEVHPPAAEDKGKFEVVPFLLSSLDGIAHIRVFLPNDLKSQGQKLTVG 834

  Fly   774 KTIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDK 838
            |.:.|.|:|||.|..:|:|:::||||:..|..::..::..|.||..:|||...|||..:..|..|
pombe   835 KALSEVKRRFPEGITLLDPVENMNIKEPTFIKLMKKVNILESRLLSNPLHNFSELEEKYAEYLRK 899

  Fly   839 VTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTE 903
            :.|.::::|||.:|..|||::|:|||..|||||||:|:....||||.|||||||:||.|.||:||
pombe   900 LALLEEVKDLKKKLSKARSIMQLDELNSRKRVLRRLGFTTSDDVIEVKGRVACEISSGDGLLLTE 964

  Fly   904 MIFNGVFNDLTAPQAVALLSCFVCDEKSS-ESVKSATELSGPLRSMQDLARRIAKVSTECKLDLD 967
            :||||:|||||..|..|||||.|..|||. |:.:...||:|||:.:|::||||||||.|.|.:|:
pombe   965 LIFNGMFNDLTPEQCAALLSCLVFQEKSEVENQRMKEELAGPLKILQEMARRIAKVSKESKQELN 1029

  Fly   968 ADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIGNTDL 1032
            .:.||:.|||.||:||.||..|:||..:|||||::|||:||..||||||:|||..|:|.||||.|
pombe  1030 EEEYVNSFKPSLMEVVYAWAHGASFAQICKMTDVYEGSLIRMFRRLEELIRQMVDAAKVIGNTSL 1094

  Fly  1033 ENKFSEGIRLLKRDIVFAASLYL 1055
            :.|..:.|..:.|||||:|||||
pombe  1095 QQKMEDTIACIHRDIVFSASLYL 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	550/1001 (55%)
		DEAD	154..299	CDD:278688	113/144 (78%)
		HELICc	390..554	CDD:238034	118/163 (72%)
		rRNA_proc-arch	600..853	CDD:289976	90/264 (34%)
		DSHCT	881..1048	CDD:285374	99/167 (59%)
mtr4	NP_001342839.1	Dob10	52..1117	CDD:226947	566/1078 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	238	1.000	Domainoid score	I469
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6257
Inparanoid	1	1.050	1069	1.000	Inparanoid score	I27
OMA	1	1.010	-	-		QHG53687
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	1	1.000	-	-		oto101633
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R764
SonicParanoid	1	1.000	-	-		X2451
TreeFam	1	0.960	-	-
	14	13.860