DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and SPCC550.03c

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_588095.1	Gene:	SPCC550.03c / 2538841	PomBaseID:	SPCC550.03c	Length:	1213	Species:	Schizosaccharomyces pombe

Alignment Length:	1132	Identity:	387/1132 - (34%)
Similarity:	592/1132 - (52%)	Gaps:	161/1132 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PSVPPPALNQE---EKPSGSSASKKGNKRQADGTTASKEATSSKGAEGDDKGDVTEEPTKRLK-Q 75
            |||......::   :.|.|.|   :|....|..||.:.          :|:.|..:..||::| .
pombe   152 PSVKMALYGEDGLLQVPPGFS---RGLSMTATSTTDNL----------NDEFDPEKWDTKKVKSS 203

  Fly    76 EASTVAVDDDN-NADDEPTRTLDIDDSATLEALRTRIVTHLLDAPKSCTHEVAAHPDQEYI---- 135
            ..:.|.:.:.| :..:..::..:|||  .|...|:     ::..|.| |..:...||..::
pombe   204 NRNFVTIHELNEHLKNVNSKHSEIDD--LLPDKRS-----IVSLPPS-TLNLHKQPDYAHVVDSS 260

  Fly   136 -PLKPFSG-VP--AKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLAAKQR 196
             |::.|.. ||  |.::||.||.||::||..::...||.|:||||||||||||||||.:.....:
pombe   261 APIENFQQLVPEMALDFPFELDNFQKEAIYHLEMGDSVFVAAHTSAGKTVVAEYAIALAQKHMTK 325

  Fly   197 VIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMREVGWV 261
            .|||:|||||||||||:|..:|:|||::||||.:||..|||:|||||||:|||||::::|:|.:|
pombe   326 AIYTSPIKALSNQKFRDFKHKFEDVGILTGDVQVNPEGSCLLMTTEILRSMLYRGADLIRDVEFV 390

  Fly   262 VFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHVVYTDYRPT 326
            :|||:||:.|.||||||||.:|:||.:|..:.||||:||.::||.||....|:..:|:.|..||.
pombe   391 IFDEVHYVNDLERGVVWEEVIIMLPPHVTLILLSATVPNTKEFASWVGRTKKKNIYVISTLKRPV 455

  Fly   327 PLQHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLA----------NAGEA-GKGDQKGR---- 376
            ||:||::..  ..:..|||:.|:|..|.:.:|...|.          |...| |:|..:||
pombe   456 PLEHYLWVK--QNMFKIVDQHGRFLMDGYKSANDALKKPDKPVIAKDNKNSARGRGAARGRGVQT 518

  Fly   377 -----HGGIKGTNAGQTNIF-KIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKL 435
                 .|..|.......|.: .::..:.::|..|||:|.||||.||.|...:...|.|...||..
pombe   519 NMMRGRGSAKSVERRDANTWVHLIGHLHKQNLLPVIVFVFSKKRCEEYVDTLTNRDLNNHQEKSE 583

  Fly   436 VDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATET 500
            |..|...|:..|.:|||.|||:..:..:|.||:.:||||||||:||.:||||..||:|.||||||
pombe   584 VHVVIEKAVARLKKEDRLLPQIGRMREMLSRGLAVHHGGLLPIIKEIVEILFQRGLVKVLFATET 648

  Fly   501 FAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKG-IVILMIDEKVSPAVG 564
            ||||:||||::|:|:..:|.||:.||.:..|||.|.:|||||||||..| ::||...|....|..
pombe   649 FAMGVNMPAKSVVFSGTQKHDGRNFRDLLPGEYTQCSGRAGRRGLDVTGTVIILSRSELPDTASL 713

  Fly   565 RDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKTLELN 629
            |.::.|.:..:.|.|.|||||:|||||||.:..|.|::|||.:..||..:|...:::  |:.|..
pombe   714 RHMIMGPSSKLISQFRLTYNMILNLLRVETLRIEDMIKRSFSENVNQTLVPQHEEKI--KSFEEK 776

  Fly   630 KLTIKDEHNIASYHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFK 694
            ...:|.|.:......|:|.| ...:.|:::..|..:        |.:..|.|.:.:..|.|:.|:
pombe   777 LSALKKEMSDVDLKEIKSCL-LSSESFKEYTKKMHF--------RAITTANGKRIFKDGRVIVFQ 832

  Fly   695 KQDQSRKNPLKAEPSVTIDVLLHVSEAAAKTGDTEPCKPNERGCMEVVPVAHTLITQISSIRVYF 759
            :.|.:|          |:.|||..|           .:.|...|  .:.||: |..|.:..|
pombe   833 QLDFTR----------TVGVLLGTS-----------IRTNASDC--TLEVAY-LNPQNNLKR--- 870

  Fly   760 PNDLRS-ADNRRAVL-KTIQEAKKRFPLGPPVLN------------PIDDMNIKDR--------- 801
            |:||.: ||....|. ..|.:...:|..|  ::|            .||...|:||
pombe   871 PSDLLAFADAFNDVYDNAIFDESNQFKYG--LINLSGIERVCNTILRIDSGGIRDRRGGAFRKLS 933

  Fly   802 -------EFRDIV------------NTISQFEKR------LEEHPLHKSPE-LERIHRRYQDKVT 840
                   :|.|::            .....||||      |..:|:..:|. |......||: ..
pombe   934 EQFASIKKFSDLLFEEVNWSKVRDFEFCEAFEKRNFLQNKLSGNPIISTPNFLTHFALAYQE-YE 997

  Fly   841 LQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMI 905
            |:..:.:|.:.: :.::|..:.:.:.|.:||:.:||......:..|||||||::|..||::||:|
pombe   998 LESNIDNLSSYI-SDQNLELLPDYEQRIKVLQELGYIDAERTVLLKGRVACEINSTSELVLTELI 1061

  Fly   906 FNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECKLDLDADT 970
            ......|.:..:.:||||.||.|||:......:..|......:..:|.::.::....::     .
pombe  1062 LENSLADFSCEETIALLSAFVFDEKTEVEPTISPHLQKGKEMILSVAEKVNQIQEHYQV-----L 1121

  Fly   971 YVDKFKPF-------LMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIG 1028
            |.::...|       ||:|...|.:|.||..:..:||:.||||:|.:.||:|:||:...|::.:|
pombe  1122 YFNEGNDFESQPRFGLMEVCYEWARGMSFNRITDLTDVLEGSIVRTIIRLDEVLRECRGAARVVG 1186

  Fly  1029 NTDLENKFSEGIRLLKRDIVFAASLYL 1055
            ::.:..|..|...|::|:|||..|||:
pombe  1187 DSSMYTKMEECQNLIRRNIVFCPSLYM 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	369/1049 (35%)
		DEAD	154..299	CDD:278688	88/144 (61%)
		HELICc	390..554	CDD:238034	82/165 (50%)
		rRNA_proc-arch	600..853	CDD:289976	65/301 (22%)
		DSHCT	881..1048	CDD:285374	52/173 (30%)
SPCC550.03c	NP_588095.1	Dob10	116..1213	CDD:226947	386/1130 (34%)
		DEAD	285..430	CDD:278688	88/144 (61%)
		HELICc	<552..702	CDD:238034	80/149 (54%)
		rRNA_proc-arch	749..1010	CDD:289976	65/302 (22%)
		DSHCT	1038..1206	CDD:285374	52/172 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710