Protein Alignment Mtr4 and MTREX

DIOPT Version :10

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_056175.3
• Gene: MTREX / 23517
• HGNCID: 18734
• Length: 1042
• Species: Homo sapiens
• Alignment Length: 1069
• Identity: 668/1069 - (62%)
• Similarity: 821/1069 - (76%)
• Gaps: 50/1069 - (4%)

  Fly     4 EELFDCF--DEVTPSVPPPALNQEEKPSG------SSASKKGNKRQADGTTASKEATSSKGAEGD 60
            :|||..|  |..|.:   .....:||..|      .||.|.|  ::.||...| |:|::    |.
Human     7 DELFSVFEGDSTTAA---GTKKDKEKDKGKWKGPPGSADKAG--KRFDGKLQS-ESTNN----GK 61

  Fly    61 DKGDV----TEEPT--KRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIVTHLLDAP 119
            :|.||    |:||.  |:.:.|.|                   |.:..:|..|..|:....::..
Human    62 NKRDVDFEGTDEPIFGKKPRIEES-------------------ITEDLSLADLMPRVKVQSVETV 107

  Fly   120 KSCTHEVAAHPDQEYIPLKPFSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAE 184
            :.||||||...:::|:||||..|..||||||:||.|||:||.|:||:|||||||||||||||.||
Human   108 EGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAE 172

  Fly   185 YAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLY 249
            ||||.:|..|||||:|:|||||||||:||..:||:||||:||||||||:||||:|||||||:|||
Human   173 YAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLY 237

  Fly   250 RGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQ 314
            ||||:||||.||:|||||||||.|||||||||:|||||||.|||||||||||||||||:||||||
Human   238 RGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQ 302

  Fly   315 PCHVVYTDYRPTPLQHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGRHGG 379
            ||||:||||||||||||||||||||:||:|||.|.|:||||.|||.||.:||:..|||||||.||
Human   303 PCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGG 367

  Fly   380 IKGTNAGQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAM 444
            .|    |.:|:||||||||||||.|||||||||||||.||:||.||||||.:|||:|:|||:||:
Human   368 TK----GPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAI 428

  Fly   445 DVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPA 509
            |.|::||::|||||:|||||:||||||||||||||||||||||.||||||||||||||||:||||
Human   429 DCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPA 493

  Fly   510 RTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADP 574
            ||||||..||||||.||||||||||||:|||||||:||:||||||:|||:||.:|:.:::|.|||
Human   494 RTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADP 558

  Fly   575 INSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNI 639
            :|||||||||||||||||||||||||||:||||||:..|:||:.::|:....:.||:.|.:|.::
Human   559 LNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESV 623

  Fly   640 ASYHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPL 704
            ..|:.||.||.:.||:..::|.||:|.||||||||||||.....::.||:|:||.|:...:.|..
Human   624 VIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSG 688

  Fly   705 KAEPSVTIDVLLHVSEAAAKTGDTE---PCKPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSA 766
            :.:|...::|||..|:.:.|...||   |.||:|:|.|:||||...|::.|||:|:|.|.|||..
Human   689 ELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPV 753

  Fly   767 DNRRAVLKTIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERI 831
            |||::|||:|||.:||||.|.|:|:|||||.|:|:..:.::..:..||.|:..||||..|.||.:
Human   754 DNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETV 818

  Fly   832 HRRYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSA 896
            :...:.|..:...::..|.|||.||::|||||||.|||||||:|:....||||.|||||||:|||
Human   819 YTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSA 883

  Fly   897 DELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTE 961
            ||||:|||:|||:||||:|.||.|||||||..|.|||..|...:|:||||.||:.|:||||||.|
Human   884 DELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAE 948

  Fly   962 CKLDLDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKT 1026
            .||::|.:||:..|||.|||||..|..|::|..:|||||:||||||||||||||||||||||:|.
Human   949 AKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKA 1013

  Fly  1027 IGNTDLENKFSEGIRLLKRDIVFAASLYL 1055
            ||||:|||||:|||..:||||||||||||
Human  1014 IGNTELENKFAEGITKIKRDIVFAASLYL 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	615/905 (68%)
MTREX	NP_056175.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..74		19/67 (28%)
		Dob10	127..1014	CDD:443638	602/890 (68%)
		DEIH box	252..255		2/2 (100%)