DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and mtr-4

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_501757.1	Gene:	mtr-4 / 177824	WormBaseID:	WBGene00012342	Length:	1026	Species:	Caenorhabditis elegans

Alignment Length:	1071	Identity:	518/1071 - (48%)
Similarity:	696/1071 - (64%)	Gaps:	70/1071 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DCFDE-VTPSVPPPALNQEEKPSGSSAS-KKGNKRQADGTTASKEATSSKGAEGDDKGDVTEEPT 70
            |.||| :.|.|....::.||.|...... ....||||                       .|:.|
Worm     3 DLFDEFIEPGVKNEIMDVEEAPENPMEKLDSAKKRQA-----------------------REDMT 44

  Fly    71 KRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALR-TRIVTHLLDAP-KSCTHEVAAHPDQE 133
            ..|....:.|.|   .|.|:..::...:::...:|..| ..|:.|.:... ::||||||..|:.|
Worm    45 NLLANMHNDVGV---GNFDEATSKRARVEEEEEVEEARMENIIVHTIRTDNENCTHEVAIPPNAE 106

  Fly   134 YIPLKPFSGV-PAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLAAKQRV 197
            :..|:..||. |||.|||.||.||:||||||||:|||||||||||||||||.|||||.|..||||
Worm   107 FAELRENSGTEPAKYYPFQLDAFQKQAILCIDNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRV 171

  Fly   198 IYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMREVGWVV 262
            |||:|||||||||:||..:|||||||:|||||:||.||||:|||||||:|||||||||:||||||
Worm   172 IYTSPIKALSNQKYRELEEEFKDVGLMTGDVTLNPDASCLVMTTEILRSMLYRGSEIMKEVGWVV 236

  Fly   263 FDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHVVYTDYRPTP 327
            :||||||||||||||||||:||:..|::..|||||||||||||:||..:.:||.:||||||||||
Worm   237 YDEIHYMRDKERGVVWEETIILMSKNIKQAFLSATIPNARQFAQWVASIKQQPVNVVYTDYRPTP 301

  Fly   328 LQHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGRHGGIKGTNAGQTNIFK 392
            |||:|:|.||:|::.:|:.||:|:||.|..||:.||.||::.....|.|.||  ||. |.:|:.|
Worm   302 LQHWIYPVGGEGMYEVVNVKGEFREDKFRDAMSGLATAGDSAGSFNKRRTGG--GTQ-GDSNVLK 363

  Fly   393 IVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTEEDRRLPQV 457
            |::.:...:....|:||||:|:||.||:.:..:|||...||.:|..|:.:|:..|:.||::|||:
Worm   364 IIRSVASNDGLNCIVFSFSRKECESYAISLKDMDFNKDHEKGMVKSVYESAIAQLSPEDQKLPQI 428

  Fly   458 ENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFTAPRKFDG 522
            .|:|||||||||:||.||:|||||||||||||||:|.|||||||:||||||||||:||:.|||||
Worm   429 LNILPLLRRGIGVHHSGLMPILKETIEILFGEGLVKVLFATETFSMGLNMPARTVVFTSARKFDG 493

  Fly   523 KKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADPINSAFHLTYNMVL 587
            ...|:|:|||||||||||||||.||:|.||||:|..:|....:.|::|..||:||.|.|||||||
Worm   494 SDNRYITSGEYIQMAGRAGRRGKDDRGTVILMVDSAMSADDAKQIIKGATDPLNSQFRLTYNMVL 558

  Fly   588 NLLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIASYH--------- 643
            ||:|||.:...:::..||:|||:.|.:|           |::|..::.|..|||::
Worm   559 NLMRVEGMAVSWIINNSFHQFQSYAKIP-----------EIDKKCVQVERKIASFNFPWENEMRT 612

  Fly   644 --HIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPLKA 706
              .::.||:...::..|...:|:|::.||..|||.||.:|.:::.|||:..|||:    :||...
Worm   613 LVDLQDQLEATRQRIIQIQREPKYIVGFLHAGRLFKVKSGDRDFKWGILNQFKKE----QNPDDR 673

  Fly   707 EPSVTIDVLLHVSEAAAKTGDTEPCK-------PNERGCMEVVPVAHTLITQISSIRVYFPNDLR 764
            ...:.:..::.......:...|.|..       |..|...  ||:....||.||::|:..|.|:.
Worm   674 NDQIYLCDMMIAINTEGRFDPTNPATLVPGFDLPKRRWIR--VPMTIDRITAISAVRLKVPADID 736

  Fly   765 SADNRRAVLKTIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELE 829
            ..|.:..:...:..|.|||....|:|:||.||.||..|.::::......|.|||.|.:.|...::
Worm   737 KPDGQMRLDGMMAAATKRFGNQIPLLDPIQDMEIKTVEMKELIAREKSLEGRLETHSMTKRDNMK 801

  Fly   830 RIHRRYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELS 894
            .:.::::.|....|:|..||||.|:.:|.|.::||.:|||||||:||....|.:..||.||||||
Worm   802 DLKKQFEQKQDAVKELNALKAERKSVQSTLHLEELNNRKRVLRRLGYLGNDDALVLKGSVACELS 866

  Fly   895 SADELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVS 959
            ::|||::|||:..|:||.|...|..|||||||..:|.: :.|.||||...|..:.:.||.:||||
Worm   867 ASDELILTEMLLKGIFNTLDVAQTAALLSCFVFQDKCA-APKLATELQTCLSELHEQARNVAKVS 930

  Fly   960 TECKLDLDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQAS 1024
            .|||:::..|.||..|.|.|||||..|..|::|..:.|.||:|||||||.:|||||:||:|..|:
Worm   931 NECKMEVMEDKYVSSFNPGLMDVVYQWVNGATFSEIVKTTDVFEGSIIRTLRRLEEVLREMINAA 995

  Fly  1025 KTIGNTDLENKFSEGIRLLKRDIVFAASLYL 1055
            |.:.|.:||.||.:..:.|||||||||||||
Worm   996 KALANKELEQKFEDARKNLKRDIVFAASLYL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	496/984 (50%)
		DEAD	154..299	CDD:278688	117/144 (81%)
		HELICc	390..554	CDD:238034	102/163 (63%)
		rRNA_proc-arch	600..853	CDD:289976	74/270 (27%)
		DSHCT	881..1048	CDD:285374	85/166 (51%)
mtr-4	NP_501757.1	Dob10	97..1026	CDD:226947	490/949 (52%)
		DEAD	130..273	CDD:278688	116/142 (82%)
		HELICc	427..515	CDD:197757	70/87 (80%)
		rRNA_proc-arch	571..825	CDD:289976	74/270 (27%)
		DSHCT	857..1019	CDD:285374	84/162 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166396
Domainoid	1	1.000	246	1.000	Domainoid score	I1201
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6257
Inparanoid	1	1.050	951	1.000	Inparanoid score	I163
Isobase	1	0.950	-	0	Normalized mean entropy	S388
OMA	1	1.010	-	-		QHG53687
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	1	1.000	-	-		oto18181
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R764
SonicParanoid	1	1.000	-	-		X2451
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750