Protein Alignment Mtr4 and HFM1

DIOPT Version :9

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_001017975.5
• Gene: HFM1 / 164045
• HGNCID: 20193
• Length: 1435
• Species: Homo sapiens
• Alignment Length: 1122
• Identity: 249/1122 - (22%)
• Similarity: 434/1122 - (38%)
• Gaps: 336/1122 - (29%)

  Fly    45 TTASKEATSSKGAE----------------GDDKGDVTEEPTKRLKQEASTV---AVDDDNNADD 90
            |.||::..:..|.|                .:|||:.|....|||.:.:..:   |..:||..|.
Human   122 TYASQKYKNHIGTEIAPEKSVPDDTKLVNFAEDKGESTSVFRKRLFKISDNIHGSAYSNDNELDS 186

  Fly    91 ----------EPTRTLDIDDSATLEALR--------------TRIVTHLLDAPKSCT----HEVA 127
                      |..:....:.|.:.:..:              :.|...:..||....    |::.
Human   187 HIGSVKIVQTEMNKGKSRNYSNSKQKFQYSANVFTANNAFSASEIGEGMFKAPSFSVAFQPHDIQ 251

  Fly   128 AHPDQEYIPLKPFSGVPA------KEYPFVLDPFQRQA---ILCIDNSQSVLVSAHTSAGKTVVA 183
            ...:.....||..:.:||      ||:|: .:..|.:|   :|..|  ::.::.|.|.:|||||.
Human   252 EVTENGLGSLKAVTEIPAKFRSIFKEFPY-FNYIQSKAFDDLLYTD--RNFVICAPTGSGKTVVF 313

  Fly   184 EYAIAKSLA------AKQRVIYTTPIKALSNQKFREFTDEFKDVGL----VTGDVTINP----SA 234
            |.||.:.|.      ...:::|..|||||.:|:|.::.::|..:||    :|||..::.    ..
Human   314 ELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQH 378

  Fly   235 SCLIMTT-----EILRNMLYRGSEIMREVGWVVFDEIHYMRDKERGVVWE--------------- 279
            :.:||||     .:.|.  :|.:.:::.|...:.||:|.::|:.||...|
Human   379 AHIIMTTPEKWDSMTRK--WRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQT 441

  Fly   280 --ETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQP--CHVVYTDYRPTPLQHYI--FPAGGD 338
              .|...:|  :|:|.:|||||||...|||:.. .::|  |..:...:||..||..:  ||...:
Human   442 LKNTSTAIP--MRFVAVSATIPNAEDIAEWLSD-GERPAVCLKMDESHRPVKLQKVVLGFPCSSN 503

  Fly   339 GIHLIVDEKGQFKED---NFTTAMAVLANAGEAGKGDQKGRHGGIKGTNAGQTNIFKIVKMIMER 400
                    :.:||.|   |:..|..:...:      |||
Human   504 --------QTEFKFDLTLNYKIASVIQMYS------DQK-------------------------- 528

  Fly   401 NFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLT-EEDRRLPQV------E 458
               |.::|..::|..:..|..:.|                 :|..::| |:.:||.:.      .
Human   529 ---PTLVFCATRKGVQQAASVLVK-----------------DAKFIMTVEQKQRLQKYAYSVRDS 573

  Fly   459 NVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFTAPRKFDGK 523
            .:..:|:.|...||.|:....::.:|..|..|.:..||.|.|.|||:|:||..|:..:...:.|.
Human   574 KLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGG 638

  Fly   524 KFRWISSGEYIQMAGRAGRRGLD--------------DKGIVILMIDEKVSPAVGRDIVQGKADP 574
            .|...|..:.:||.|||||...|              ||.|.:|...:.|..::.|.:::
Human   639 LFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRDKYIQMLACRDTVESSLHRHLIE----- 698

  Fly   575 INSAFHLTYNMVLNL-----LRVEEINPEYMLERSFYQFQNQAALPGLH-DQVEQKTLELNKLTI 633
                 ||...:||:.     :.||.|....:..|:.....:.....||: |.:|.|   |.:|.:
Human   699 -----HLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGFASGLNKDGIEAK---LQELCL 755

  Fly   634 KDEHNIASYHHIRSQLDQHGKQFR----------QWIT----KPQYLLPFLQPGR-----LVKVA 679
            |:.::::|...|:  :|: |..|:          .:||    |..|.:    .|:     ||.:.
Human   756 KNLNDLSSLDLIK--MDE-GVNFKPTEAGRLMAWYYITFETVKKFYTI----SGKETLSDLVTLI 813

  Fly   680 AGSQEY-DWGIVLNFKKQDQSRKNPLKAEPS-VTIDVLLHVSEAAAKTGDTEPCKPN-----ERG 737
            ||.:|: |..:.:|.||    ..|.|..:|: :||...:   |...||.:   .|.|     :.|
Human   814 AGCKEFLDIQLRINEKK----TLNTLNKDPNRITIRFPM---EGRIKTRE---MKVNCLIQAQLG 868

  Fly   738 CMEVVPVAHTLITQISSIRVYFPNDLRSADNRRAVLKTIQEAKKRFPLGPPVLNPIDD-MNIKDR 801
            |   :|:....:|                          |:..|.|..|..:...:.| :..:::
Human   869 C---IPIQDFALT--------------------------QDTAKIFRHGSRITRWLSDFVAAQEK 904

  Fly   802 EFRDIVNTI---SQFEKRLEEHPLHKSPELERIHRRYQDKVTLQKQLQDLKAELKAARSLLQMDE 863
            :|..::|::   ..|..:|.|:.||.|.:||:|      .:||...:  :.|.|.:.:.:.:.|
Human   905 KFAVLLNSLILAKCFRCKLWENSLHVSKQLEKI------GITLSNAI--VNAGLTSFKKIEETD- 960

  Fly   864 LKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMIFNGVFNDLTAPQAVALLSCFVCD 928
            .:..:.:|.|    .|....:.|..|   :......|..|.|..  ::|.||...|.::
Human   961 ARELELILNR----HPPFGTQIKETV---MYLPKYELKVEQITR--YSDTTAEILVTVI------ 1010

  Fly   929 EKSSESVKSATELSGPLRSMQDL-ARRIAKVSTECKLDL-DAD---TYVDKFKPFLMDVVL---- 984
                            ||:.:.| .:|.|..|....|.: |||   .|:.|    :.|.||
Human  1011 ----------------LRNFEQLQTKRTASDSHYVTLIIGDADNQVVYLHK----ITDSVLLKAG 1055

  Fly   985 AWCKGSSFLAVCKMTDI 1001
            :|.|..:.....|..|:
Human  1056 SWAKKIAVKRALKSEDL 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	233/1047 (22%)
		DEAD	154..299	CDD:278688	50/183 (27%)
		HELICc	390..554	CDD:238034	43/184 (23%)
		rRNA_proc-arch	600..853	CDD:289976	61/283 (22%)
		DSHCT	881..1048	CDD:285374	28/130 (22%)
HFM1	NP_001017975.5	BRR2	264..970	CDD:224125	195/841 (23%)
		DEXHc_HFM1	280..488	CDD:350781	59/215 (27%)
		DEAH box	411..414		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1109..1139
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1295..1315

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920