DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and IPO7

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_006382.1	Gene:	IPO7 / 10527	HGNCID:	9852	Length:	1038	Species:	Homo sapiens

Alignment Length:	1016	Identity:	182/1016 - (17%)
Similarity:	326/1016 - (32%)	Gaps:	393/1016 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 LDPFQRQAILCIDNSQSVLVSAHTSAG-KTVVAEYAIAKSLAAKQR---VIYTTPIKALSNQKFR 212
            :||..|:|      ::..|..||.|.. .:.:.:..:::.|....|   |||      |.|.
Human    14 MDPALREA------AERQLNEAHKSLNFVSTLLQITMSEQLDLPVRQAGVIY------LKNM--- 63

  Fly   213 EFTDEFKDVGLVTGDV---TINPS---------ASCLIMTTEILRNML-------------YRGS 252
             .|..:.|.....||:   ||...         ...:|.:.|::|..|             .|.:
Human    64 -ITQYWPDRETAPGDISPYTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKHDYPSRWT 127

  Fly   253 EIMREVG----------WV--------VFDEIHYMRDKERG-----------VVWEETLILLPD- 287
            .|:.::|          |:        :.....|.:.:||.           |:.:..:.||.|
Human   128 AIVDKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQ 192

  Fly   288 ------------NVRYVFLSATIP----NARQFAEWVCHLHKQPCHVVYTDYRPTPLQHYIFPAG 336
                        .:.|..:..|:|    |.:...||:..|..    ||..|
Human   193 SDQSVLIQKQIFKIFYALVQYTLPLELINQQNLTEWIEILKT----VVNRD-------------- 239

  Fly   337 GDGIHLIVDEKGQFKEDNFTT---------AMAVLANAGEAGKGDQKGRHGGIKGTNAGQTNIFK 392
                  :.:|..|.:||:...         |:.:||...|        |:|       ...|:.|
Human   240 ------VPNETLQVEEDDRPELPWWKCKKWALHILARLFE--------RYG-------SPGNVSK 283

  Fly   393 IVKMIMERN-FAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTEEDRRLPQ 456
                  |.| ||.|.:.:|:....::    :.|:.:...:::.:...|....::.:.:.......
Human   284 ------EYNEFAEVFLKAFAVGVQQV----LLKVLYQYKEKQYMAPRVLQQTLNYINQGVSHALT 338

  Fly   457 VENVLPLLRRGIGIHHGGLLPIL--KETIEILFGEGLIKAL---------FATETFAMGLNMPAR 510
            .:|:.|.::   ||....:.|::  .:..|.|:.|...:.:         |.:.|.|      |:
Human   339 WKNLKPHIQ---GIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFISPTTA------AQ 394

  Fly   511 TVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADP- 574
            |:||||..|   :|       |.:|..          .|....::.|.            .|||
Human   395 TLLFTACSK---RK-------EVLQKT----------MGFCYQILTEP------------NADPR 427

  Fly   575 -INSAFHLTYNMVLNLL--RVEEINPEYMLERSFYQ-------FQNQAALPGLH---------DQ 620
             .:.|.|:..::...||  ::.:...||||:...:.       :....|...||         ||
Human   428 KKDGALHMIGSLAEILLKKKIYKDQMEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQ 492

  Fly   621 VEQKTLELNK--------LTIKDEHNIASYHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVK 677
            ..|..|||.:        :.:|.|..||....|.:|  :..|         :|:.||::|
Human   493 NLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQ--EKAK---------EYITPFIRP----- 541

  Fly   678 VAAGSQEYDWGIVLNFKKQDQSRKNPLKAEPSVTIDVLLHVSEAAAKTGDTEP-----CKPNERG 737
                                             .:..|||:.........|..     |:.:|
Human   542 ---------------------------------VMQALLHIIRETENDDLTNVIQKMICEYSE-- 571

  Fly   738 CMEVVPVAHTLITQISSIRVYFPNDLRSADNRRAVLKTIQEAKKRFPLGPPVLNPIDDMNIKDRE 802
              ||.|:|           |.....|....|:  |::|          ||      |:....|:.
Human   572 --EVTPIA-----------VEMTQHLAMTFNQ--VIQT----------GP------DEEGSDDKA 605

  Fly   803 F--RDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDKVTLQKQLQDLKAELKAARSLLQMDELK 865
            .  ..|:|||......:|:|.                  .:.:||:.:.  |:...::||...|:
Human   606 VTAMGILNTIDTLLSVVEDHK------------------EITQQLEGIC--LQVIGTVLQQHVLE 650

  Fly   866 HRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMIFN-------GVFNDLTAPQAVALLS 923
            ..:            ::......:.|:..|.....:..::|.       ..|.|:     :.||.
Human   651 FYE------------EIFSLAHSLTCQQVSPQMWQLLPLVFEVFQQDGFDYFTDM-----MPLLH 698

  Fly   924 CFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECKLDL------DADTYVDKFKPFLMDV 982
            .:|       :|.:.|.||.        .:.:..:.:.||..|      ||:.:..|    |::|
Human   699 NYV-------TVDTDTLLSD--------TKYLEMIYSMCKKVLTGVAGEDAECHAAK----LLEV 744

  Fly   983 VLAWCKGSSFLAVCKMTDIF-EGSIIRCMRRLE-ELLRQMC 1021
            ::..|||.   .:.:...:| |.::.|..|.:: ..||.||
Human   745 IILQCKGR---GIDQCIPLFVEAALERLTREVKTSELRTMC 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	182/1016 (18%)
		DEAD	154..299	CDD:278688	37/215 (17%)
		HELICc	390..554	CDD:238034	31/175 (18%)
		rRNA_proc-arch	600..853	CDD:289976	49/283 (17%)
		DSHCT	881..1048	CDD:285374	31/156 (20%)
IPO7	NP_006382.1	SXM1	15..997	CDD:227943	182/1015 (18%)
IPO7	NP_006382.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	881..910
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900