Protein Alignment Mtr4 and IPO8

DIOPT Version :10

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_006381.2
• Gene: IPO8 / 10526
• HGNCID: 9853
• Length: 1037
• Species: Homo sapiens
• Alignment Length: 749
• Identity: 142/749 - (18%)
• Similarity: 264/749 - (35%)
• Gaps: 227/749 - (30%)

  Fly   392 KIVKMIMERNFAPVIIFSFSKKDCEI-YAMQMAKLDFNTPDEKKLVD--EVFNNAMD-------- 445
            :||:::.:.::..|::   .|:..:| ||:....|.....:.:.:..  |:|...:|
Human   185 QIVQLLPDSSYYSVLL---QKQILKIFYALVQYALPLQLVNNQTMTTWMEIFRTIIDRTVPPETL 246

  Fly   446 VLTEEDRRLPQ----------VENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATET 500
            .:.|:||  |:          :..|..|..|     :|....:.||..|  |.|      |..:|
Human   247 HIDEDDR--PELVWWKCKKWALHIVARLFER-----YGSPGNVTKEYFE--FSE------FFLKT 296

  Fly   501 FAMGLNMPARTVL-------FTAPRKFDGKKFRWISSGEYIQMAGRAGR---RGLDDKGIVILMI 555
            :|:|:......:|       :.|||... :.|.:::.|....:..:..:   :.:.:..|..:|.
Human   297 YAVGIQQVLLKILDQYRQKEYVAPRVLQ-QAFNYLNQGVVHSITWKQMKPHIQNISEDVIFSVMC 360

  Fly   556 ----DEKV---SP----AVGRDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYM-------LE 602
                ||::   .|    .:..||.:..|.|..:|..|.|...   .:.:|:.|:.|       .:
Human   361 YKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAA---KKRKEVLPKMMAFCYQILTD 422

  Fly   603 RSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIASYHHIRSQLDQHGKQFRQ---WITKPQ 664
            .:|...:...||..:....|   :.|.|...||:..:...:|:...|..:....|.   |:....
Human   423 PNFDPRKKDGALHVIGSLAE---ILLKKSLFKDQMELFLQNHVFPLLLSNLGYLRARSCWVLHAF 484

  Fly   665 YLLPF---LQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPLKAEPSVTIDVLLHVSEAAAKTG 726
            ..|.|   |.....|::|.             |...:.::.|:|.|.::.:..|:. ::..||
Human   485 SSLKFHNELNLRNAVELAK-------------KSLIEDKEMPVKVEAALALQSLIS-NQIQAK-- 533

  Fly   727 DTEPCKPNERGCM-------------EVVPVAHTLI----TQISSIRVYFPNDLRSADNRRAVLK 774
              |..||:.|..|             :|..|...:|    .:::||.|.....|.....:.....
Human   534 --EYMKPHVRPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSD 596

  Fly   775 TIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDKV 839
            ..:|.:.:..:...:|:.|           |.:.|:.:..|.:.:       :||.|..|..|.|
Human   597 EYEEVEDKTVMAMGILHTI-----------DTILTVVEDHKEITQ-------QLENICLRIIDLV 643

  Fly   840 TLQKQLQDLKAE-LKAARSLL------QMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSAD 897
             |||.:.:...| |..|.||.      ||.:|         :|
Human   644 -LQKHVIEFYEEILSLAYSLTCHSISPQMWQL---------LG---------------------- 676

  Fly   898 ELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTEC 962
              ::.|:.....|...|  ..:.||..:|       ::.:.|.||.        |:.:..:.|.|
Human   677 --ILYEVFQQDCFEYFT--DMMPLLHNYV-------TIDTDTLLSN--------AKHLEILFTMC 722

  Fly   963 KLDL------DADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEEL-LRQM 1020
            :..|      ||:.:..|    |::|::..|||.              .|.:|:....:| |.::
Human   723 RKVLCGDAGEDAECHAAK----LLEVIILQCKGR--------------GIDQCIPLFVQLVLERL 769

  Fly  1021 CQASKTIGNTDLENKFSEGIRLLKRDIVFAASLY 1054
            .:..||          || :|.:...:..||..|
Human   770 TRGVKT----------SE-LRTMCLQVAIAALYY 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	139/741 (19%)
IPO8	NP_006381.2	SXM1	15..996	CDD:227943	142/749 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	886..934