DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and mtrex

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	XP_002941157.1	Gene:	mtrex / 100496866	XenbaseID:	XB-GENE-1013876	Length:	1031	Species:	Xenopus tropicalis

Alignment Length:	1056	Identity:	668/1056 - (63%)
Similarity:	817/1056 - (77%)	Gaps:	35/1056 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EELFDCFDEVTPSVPPPALNQEEKPSGSSASKKGNKRQADGTTASKEATSSKGAEGDDKGDVTEE 68
            :|||..|:|.||:....||        .:|:.|..||.|          .||||...
Frog     7 DELFSVFEEETPATSKSAL--------PAAAGKTGKRNA----------KSKGAGAG-------- 45

  Fly    69 PTKRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIVTHLLDAPKSCTHEVAAHPDQE 133
            |..:.|:||..:...|:.....:|...:...|...|..|..||....::..:.||||||...|:|
Frog    46 PAPKAKREADCIDGPDEVVFGKKPKLEISSADDINLADLMPRIKVQEVETVEGCTHEVALPADEE 110

  Fly   134 YIPLKPFSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLAAKQRVI 198
            |:||||..|..|||||||||.|||:|||||||:|||||||||||||||.|||:||.:|..|||||
Frog   111 YVPLKPRVGKAAKEYPFVLDAFQREAILCIDNNQSVLVSAHTSAGKTVCAEYSIALALREKQRVI 175

  Fly   199 YTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMREVGWVVF 263
            :|:|||||||||:||..:||:||||:||||||||:||||:|||||||:|||||||:||||.||:|
Frog   176 FTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIF 240

  Fly   264 DEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHVVYTDYRPTPL 328
            ||||||||.|||||||||:|||||||.|||||||||||||||||:||||||||||:|||||||||
Frog   241 DEIHYMRDAERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPL 305

  Fly   329 QHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGRHGGIKGTNAGQTNIFKI 393
            ||||||:||||:||:|||.|.|:||||.|||.||.:||:..|||||||.||.|    |.:|:|||
Frog   306 QHYIFPSGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTK----GPSNVFKI 366

  Fly   394 VKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTEEDRRLPQVE 458
            |||||||||.|||||||||||||.||:||:||||||.:|||:|:||||||:|.|::||::|||||
Frog   367 VKMIMERNFQPVIIFSFSKKDCEAYALQMSKLDFNTDEEKKMVEEVFNNAIDCLSDEDKKLPQVE 431

  Fly   459 NVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFTAPRKFDGK 523
            :|||||:||||||||||||||||||||||.|||:||||||||||||:||||||||||:.||||||
Frog   432 HVLPLLKRGIGIHHGGLLPILKETIEILFSEGLLKALFATETFAMGINMPARTVLFTSARKFDGK 496

  Fly   524 KFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADPINSAFHLTYNMVLN 588
            .||||||||||||:|||||||:|::||||||:|||:||.||:.:::|.|||:|||||||||||||
Frog   497 DFRWISSGEYIQMSGRAGRRGMDERGIVILMVDEKMSPTVGKQLLKGSADPLNSAFHLTYNMVLN 561

  Fly   589 LLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIASYHHIRSQLDQHG 653
            ||||||||||||||:||||||:..|:||:.::|::...:.|.:.|.:|.|:.:|:.||.||.:.|
Frog   562 LLRVEEINPEYMLEKSFYQFQHYRAIPGVAEKVKKLEEQYNSIQIPNEENVVTYYKIRQQLAKLG 626

  Fly   654 KQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPLKAEPSVTIDVLLHV 718
            |:...:|.||:|.|||:||||||||.:...::.||.|:||.|:...:.|..:.:|...::||::.
Frog   627 KEIEDYIHKPKYCLPFMQPGRLVKVKSEDDDFGWGAVVNFSKKSNVKPNSGELDPLYVVEVLINC 691

  Fly   719 SEAAAKTGDTE---PCKPNERGCMEVVPV-AHTLITQISSIRVYFPNDLRSADNRRAVLKTIQEA 779
            |:.:.|...||   |.:|:|||.|:|||| .|||.. |||:|:|.|.|||:.|||::|||:|||.
Frog   692 SKESVKNAATEAAKPARPDERGEMQVVPVMLHTLCA-ISSVRLYIPKDLRTTDNRQSVLKSIQEV 755

  Fly   780 KKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDKVTLQKQ 844
            :||||.|.|:|:|||||.|||...:.:|.....||.|:..|||:..|.||.:::..:.|..:...
Frog   756 QKRFPDGVPLLDPIDDMGIKDPGLKKVVQKTEAFEHRMYSHPLNNDPNLESLYKLCEKKAQIAVD 820

  Fly   845 LQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMIFNGV 909
            ::..|.|||.||::|||||||.|||||||:|:....||||.|||||||:|||||||:|||:|||:
Frog   821 IRAAKRELKKARTVLQMDELKCRKRVLRRLGFATASDVIEMKGRVACEISSADELLLTEMMFNGL 885

  Fly   910 FNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECKLDLDADTYVDK 974
            ||||||.||.|||||||..|.|||..|...:|:||||.||:.||||||||.|.||::|.:||:..
Frog   886 FNDLTAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQETARRIAKVSAEAKLEVDEETYLGS 950

  Fly   975 FKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIGNTDLENKFSEG 1039
            |:..||||:..|..|::|..:|||||:||||||||||||||||||||||:|.||||:|||||:||
Frog   951 FRSNLMDVLYTWANGATFAQICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEG 1015

  Fly  1040 IRLLKRDIVFAASLYL 1055
            |..:||||||||||||
Frog  1016 ITKIKRDIVFAASLYL 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	643/967 (66%)
		DEAD	154..299	CDD:278688	118/144 (82%)
		HELICc	390..554	CDD:238034	136/163 (83%)
		rRNA_proc-arch	600..853	CDD:289976	112/256 (44%)
		DSHCT	881..1048	CDD:285374	116/166 (70%)
mtrex	XP_002941157.1	Dob10	101..1031	CDD:226947	635/934 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2084
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6257
Inparanoid	1	1.050	1314	1.000	Inparanoid score	I153
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	1	1.000	-	-		oto104496
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R764
SonicParanoid	1	1.000	-	-		X2451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090