DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant35A and GALNT12

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_078918.3	Gene:	GALNT12 / 79695	HGNCID:	19877	Length:	581	Species:	Homo sapiens

Alignment Length:	590	Identity:	210/590 - (35%)
Similarity:	313/590 - (53%)	Gaps:	82/590 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LVAVVWLLALLFYSHSLRSSIRSAGWRIDEGNATPRAELSYQARVTVGCTPNASITTGESPAAPK 82
            |:.::.||||......||:. |.||    .|.|.|.             .|.........|..|:
Human    21 LLVLLALLALAGLGSVLRAQ-RGAG----AGAAEPG-------------PPRTPRPGRREPVMPR 67

  Fly    83 PP---------SDPEQLELLGVVRNKQDKYIRDIGYKHHAFNALVSNNIGLFRAIPDTRHKVCDR 138
            ||         .:..:|:|.|.....|::.:|     .|..|..:|:.|.|.|.:|:..:.:| :
Human    68 PPVPANALGARGEAVRLQLQGEELRLQEESVR-----LHQINIYLSDRISLHRRLPERWNPLC-K 126

  Fly   139 QETTEAENLPQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDL 203
            ::..:.:|||:.|:::.||||...||:|::.:|||.:|..||.|:|||||:||...|:..|..:|
Human   127 EKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANEL 191

  Fly   204 RARLKYDNLRYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLA 268
            ....|   :|.|:..:||||:|:|::||..|.||||.|||.|.|.::.||||||:.|..|.:.:.
Human   192 SGLPK---VRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVV 253

  Fly   269 VPVIDLINADTFEY---TPSPLVRGGFNWGLHFRWENLPEG---TLKVPEDFRGPFRSPTMAGGL 327
            .||||:|:.:||||   :..|.: |||:|.|.|.|..:||.   .::.|.|.   .|||||||||
Human   254 CPVIDVIDWNTFEYLGNSGEPQI-GGFDWRLVFTWHTVPERERIRMQSPVDV---IRSPTMAGGL 314

  Fly   328 FAVNRKYFQHLGEYDMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANT 392
            |||::|||::||.||..|::|||||:|.|||.|||||.::..|||.|||:|.|:.||:    .|.
Human   315 FAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYS----RNK 375

  Fly   393 MLKNSLRLAHVWMDQYKDYYLKHEKVPKTYDYGDISDRLKLRERLQCRDFAWYLKNVYPELHVPG 457
            .|.||:|.|.||||::|:.|.......:...:||:::|.:||::|||:||.|:|:.||||||||.
Human   376 ALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPE 440

  Fly   458 EESKKSAAAPIFQPWHSRKRNYVDTF-QLRLTG-TELCAAVVAPKVKGFWKKGSSLQLQTCR-RT 519
            :.       |.|             | .|:..| |:.|.....|.....  .|..:.|..|. ..
Human   441 DR-------PGF-------------FGMLQNKGLTDYCFDYNPPDENQI--VGHQVILYLCHGMG 483

  Fly   520 PNQLWYETEKAEIVL-----DKLLCLEASGDAQVTVNKCHEMLGDQQWRHTRNANSPVYNMAKGT 579
            .||.:..|.:.||..     :..:.:||..|..: ::.|.|...:.| :.....:..:::.....
Human   484 QNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLI-MHLCEETAPENQ-KFILQEDGSLFHEQSKK 546

  Fly   580 CLRAA 584
            |::||
Human   547 CVQAA 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	143/304 (47%)
		RICIN	489..610	CDD:214672	21/103 (20%)
		RICIN	490..609	CDD:238092	20/101 (20%)
GALNT12	NP_078918.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..67		7/40 (18%)
		WcaA	134..429	CDD:223539	145/305 (48%)
		Catalytic subdomain A	135..244		54/111 (49%)
		pp-GalNAc-T	139..433	CDD:133004	143/304 (47%)
		Catalytic subdomain B	304..366		40/64 (63%)
		Ricin_B_lectin	445..574	CDD:279046	24/124 (19%)
		RICIN	447..576	CDD:238092	22/109 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820