DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant35A and Galntl5

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_080725.2	Gene:	Galntl5 / 67909	MGIID:	1915159	Length:	431	Species:	Mus musculus

Alignment Length:	474	Identity:	183/474 - (38%)
Similarity:	269/474 - (56%)	Gaps:	68/474 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKRLLCKSCGLGTLLVAVVWLLALLFYSHSLRSSIRSAGWRIDEGNATPRAELSYQARVTVGCTP 68
            |:.|.|....:|      :|...||.:.|            :::.:.....:.....:.::|  .
Mouse     6 IQGLFCGFLAIG------LWASMLLLFLH------------LEQEDMLENEKEELLKKRSLG--K 50

  Fly    69 NASITTGESPAAPKPP---SDPEQLELLGVVRNKQDKYIRDIGYKHHAFNALVSNNIGLFRAIPD 130
            ||...|..|.......   ||||.::                |.:.:..||::|..:|:.|.:||
Mouse    51 NAHQQTRHSEDVTHDEVNFSDPELIQ----------------GLRRYGLNAIMSRRLGIEREVPD 99

  Fly   131 TRHKVCDRQETTEAENLPQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHSDLPEL 195
            :|.|:|  |:.....|||.|||::|||||...||:|::.:|:..:|.:||.|||||||.|:.
Mouse   100 SRDKIC--QQKHYPFNLPTASIIICFYNEEFNTLLRAVSSVVNLSPQHLLEEIILVDDMSEF--- 159

  Fly   196 EFHLHGDLRARLKY------DNLRYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLE 254
                 .||:.:|.|      ..::.|:|::|||||||::|||..|.||:|||||||.|||:.|||
Mouse   160 -----DDLKDKLDYYLEIFRGKVKLIRNKKREGLIRSKMIGASRASGDILVFLDSHCEVNRVWLE 219

  Fly   255 PLLRLIKSENATLAVPVIDLINADTFEYTPSPLVRGGFNWGLHFRWENLPEGTLKVPEDFRGPFR 319
            |||..|..::..:..|:||:||..|.:|..:|:|||.|:|.|:.||:|:....|..||....|.|
Mouse   220 PLLHAIAKDHKMVVCPIIDVINELTLDYMAAPIVRGAFDWNLNLRWDNVFAYELDGPEGPSTPIR 284

  Fly   320 SPTMAGGLFAVNRKYFQHLGEYDMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGH----IFRK 380
            ||.|.||:||:||.||..||:||..|||.||||:|:|.|.|.|||.:.|:||||||:    :.:.
Mouse   285 SPAMTGGIFAINRHYFNELGQYDNGMDICGGENVELSLRIWMCGGQLFILPCSRVGYNSKALSQH 349

  Fly   381 RRPYTSPDGANTMLKNSLRLAHVWMDQYK-DYYLKHEKVPKTY-DYGDISDRLKLRERLQCRDFA 443
            ||...|     .:.:|.||:.|||:|:|| :::|:...:  || ..|:||:|::||:||.|:.|.
Mouse   350 RRANQS-----ALSRNLLRVVHVWLDEYKGNFFLQRPSL--TYVSCGNISERVELRKRLGCKSFQ 407

  Fly   444 WYLKNVYPELHVPGEESKK 462
            |||.|::|||.....|.|:
Mouse   408 WYLDNIFPELEPFNTERKR 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	145/310 (47%)
		RICIN	489..610	CDD:214672
		RICIN	490..609	CDD:238092
Galntl5	NP_080725.2	Catalytic subdomain A	114..224		60/117 (51%)
		pp-GalNAc-T	118..414	CDD:133004	145/310 (47%)
		Glyco_tranf_2_2	118..380	CDD:287123	129/274 (47%)
		Catalytic subdomain B	282..344		38/61 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842579
Domainoid	1	1.000	201	1.000	Domainoid score	I3004
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367513at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850