Protein Alignment Pgant35A and GALNT9

DIOPT Version :10

• Sequence 1: NP_652069.2
• Gene: Pgant35A / 48775
• FlyBaseID: FBgn0001970
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_001116108.1
• Gene: GALNT9 / 50614
• HGNCID: 4131
• Length: 603
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 186/526 - (35%)
• Similarity: 272/526 - (51%)
• Gaps: 87/526 - (16%)

  Fly   104 IRDIG------YKHHAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAENLPQASIVMCFYNEHKM 162
            :||.|      |:.:.:||.:|:.|.|.|:|||.|.:.|  ::.:.|::|||.|:|..|.||...
Human   103 LRDDGQEAEGKYEEYGYNAQLSDRISLDRSIPDYRPRKC--RQMSYAQDLPQVSVVFIFVNEALS 165

  Fly   163 TLMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARLKYDNLRY------IKNEQRE 221
            .::||:.:|:..|||.||:|:|||||:||..||:|:|.       :|.|.||      ::|.:||
Human   166 VILRSVHSVVNHTPSQLLKEVILVDDNSDNVELKFNLD-------QYVNKRYPGLVKIVRNSRRE 223

  Fly   222 GLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLINADTFEYTPSP 286
            ||||:|:.|.:.|...|:.|.|:|:|.|..|.||.|..|:.:...:.:|.||.|...|||.....
Human   224 GLIRARLQGWKAATAPVVGFFDAHVEFNTGWAEPALSRIREDRRRIVLPAIDNIKYSTFEVQQYA 288

  Fly   287 LVRGGFNWGLHFRWENLPEGTLKVPEDF--RG----PFRSPTMAGGLFAVNRKYFQHLGEYDMAM 345
            ....|:||||...:       :..|:|:  ||    |.|:|.|.|..|.|:|:||..:|..|..|
Human   289 NAAHGYNWGLWCMY-------IIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIGLLDPGM 346

  Fly   346 DIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVWMDQYKD 410
            :::||||:|:..|.|||||:::::|||||.||.|.|:||.: |......:|:||.|.||||.:|.
Human   347 EVYGGENVELGMRVWQCGGSMEVLPCSRVAHIERTRKPYNN-DIDYYAKRNALRAAEVWMDDFKS 410

  Fly   411 YYLKHEKVPKT---YDYGDISDRLKLRERLQCRDFAWYLKNVYPELHV------PGEESKKSAAA 466
            :......:|.:   .|:||:|:||.||:||:||.|.|||:|||||:.|      .||.....|:|
Human   411 HVYMAWNIPMSNPGVDFGDVSERLALRQRLKCRSFKWYLENVYPEMRVYNNTLTYGEVRNSKASA 475

  Fly   467 ------------PIFQPWHSRKRNYV-----DTFQLRLTGTELCAAVVAPKVKGFWKKGSSLQ-- 512
                        .|..|.|......|     ...||...|    :....|..|.....|:...
Human   476 YCLDQGAEDGDRAILYPCHGMSSQLVRYSADGLLQLGPLG----STAFLPDSKCLVDDGTGRMPT 536

  Fly   513 LQTCR---RTPNQLWYETEKAEIV---LDKLLCLEASGDA----QVTVNKCHEMLGDQQW----- 562
            |:.|.   |...:||..|:...||   ..:.|.:|.|.||    ::.|.:|    ..|:|
Human   537 LKKCEDVARPTQRLWDFTQSGPIVSRATGRCLEVEMSKDANFGLRLVVQRC----SGQKWMIRNW 597

  Fly   563 -RHTRN 567
             :|.|:
Human   598 IKHARH 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	129/313 (41%)
		beta-trefoil_Ricin_GALNT11	478..609	CDD:467318	26/113 (23%)
GALNT9	NP_001116108.1	Catalytic subdomain A	150..261		52/117 (44%)
		pp-GalNAc-T	154..453	CDD:133004	129/313 (41%)
		Catalytic subdomain B	318..380		31/61 (51%)
		beta-trefoil_Ricin_GALNT9	456..600	CDD:467351	32/151 (21%)