DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant35A and galnt11

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_031759178.1	Gene:	galnt11 / 448751	XenbaseID:	XB-GENE-981830	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	617	Identity:	270/617 - (43%)
Similarity:	364/617 - (58%)	Gaps:	53/617 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RLLCKSCGLGTLLVAVVWLLALLFYSHSLRSSIRSAGWR------IDEGNATPRAELSYQARVTV 64
            |..|..|    |..:|.|.|.|..|   ...|..|.|:|      ::.....|:......:|.::
Frog     7 RCFCYGC----LFTSVTWTLLLFIY---FNFSEESQGFRHVPVKGLEPYKPLPKKIYPRFSRDSM 64

  Fly    65 GCTPNASITTGESPAAPKPPSDPEQLEL---------LGVVRNKQDKYIRDIGYKHHAFNALVSN 120
            |           ..:.|:...:..|||.         ||::.|:||:.:||:||:.||||.|:||
Frog    65 G-----------QHSDPRKGHNGNQLETEANADLSPELGMIFNEQDQDVRDVGYQKHAFNLLISN 118

  Fly   121 NIGLFRAIPDTRHKVCDRQETTEAENLPQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIIL 185
            .:|..|.:||||...|.::  |...:||.||||:|||||....|:|::.:||:|||:.||.||||
Frog   119 RLGYHRDVPDTRDSKCAKK--TYPPDLPMASIVICFYNEAFSALLRTVHSVLDRTPAQLLHEIIL 181

  Fly   186 VDDHSDLPELEFHLHGDLRARLKYDNLRYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQ 250
            |||:|:|.:|:..|.|.::..|. ..::.::|:|||||||.|::||..|.||||||||||.|||:
Frog   182 VDDNSELDDLKKDLDGYMQENLS-KKVKLVRNKQREGLIRGRMVGASHATGDVLVFLDSHCEVNE 245

  Fly   251 QWLEPLLRLIKSENATLAVPVIDLINADTFEYTPSPLVRGGFNWGLHFRWENLPEGTLKVPEDFR 315
            .||:|||..||....|:..||||:|:|||..|:.||:|||||||||||:|:.:|...|..||.|.
Frog   246 MWLQPLLAPIKENPRTVVCPVIDIISADTLIYSSSPVVRGGFNWGLHFKWDPVPLAELGGPEGFS 310

  Fly   316 GPFRSPTMAGGLFAVNRKYFQHLGEYDMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRK 380
            .|||||||||||||::|:||..||:||..||||||||:|||||.|.|||::.|||||||||||||
Frog   311 APFRSPTMAGGLFAMDREYFNMLGQYDSGMDIWGGENLEISFRIWMCGGSLLIVPCSRVGHIFRK 375

  Fly   381 RRPYTSPDGANTMLKNSLRLAHVWMDQYKDYYLKHEKVPKTYDYGDISDRLKLRERLQCRDFAWY 445
            ||||.||.|.:||..|||||||||||:|||.|.......:..|:|||.:||.||.||.|:.|.||
Frog   376 RRPYGSPGGHDTMAHNSLRLAHVWMDEYKDQYFALRPELRNRDFGDIRERLALRRRLNCKSFKWY 440

  Fly   446 LKNVYPELHVPGEESKKSAAAPIFQPWHSRKRNYVDTFQLRLTGTELCAAVVA---PKVKGFWKK 507
            |.|:|||:.|.|..:|..  .|:|.....::...:...:|....|..|  :||   |..||
Frog   441 LDNIYPEMQVSGPNAKPQ--PPVFMNKGQKRPKILQRGRLINMQTNRC--LVAQGHPSQKG---- 497

  Fly   508 GSSLQLQTCRRTPNQLWYETEKAEIVLDKLLCLEAS---GDAQVTVNKCHEMLGDQQWRHTRNAN 569
            |..:..:.......|:|...|:.|::|..||||:.|   ......:.|||...|.|||  ....:
Frog   498 GLVVAKECDYNDSEQVWSYNEEHELILSNLLCLDMSETRSSDPPRLMKCHGSGGSQQW--VFGKS 560

  Fly   570 SPVYNMAKGTCLRAAAP-TTGALISLDLCSKS 600
            :.:|.::.|.||:...| :....:|:.:|..|
Frog   561 NRLYQVSVGQCLKLVDPMSRKGYVSMAICDGS 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	181/298 (61%)
		RICIN	489..610	CDD:214672	33/119 (28%)
		RICIN	490..609	CDD:238092	33/118 (28%)
galnt11	XP_031759178.1	pp-GalNAc-T	147..445	CDD:133004	181/298 (61%)
galnt11	XP_031759178.1	Ricin_B_lectin	476..597	CDD:395527	34/125 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2561
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11126
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1421
OMA	1	1.010	-	-		QHG50170
OrthoDB	1	1.010	-	-		D367513at33208
OrthoFinder	1	1.000	-	-		FOG0006575
OrthoInspector	1	1.000	-	-		oto104068
Panther	1	1.100	-	-	LDO	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080