DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant35A and GALNTL6

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_016863733.1	Gene:	GALNTL6 / 442117	HGNCID:	33844	Length:	609	Species:	Homo sapiens

Alignment Length:	500	Identity:	185/500 - (37%)
Similarity:	270/500 - (54%)	Gaps:	64/500 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 DIGYKHHAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAENLPQASIVMCFYNEHKMTLMRSIKT 170
            |..|:.:.||..|||||.|.|::||.||..|  :.....|.||..||::.|:||...:|:|:|.:
Human   108 DSAYRENGFNIFVSNNIALERSLPDIRHANC--KHKMYLERLPNTSIIIPFHNEGWTSLLRTIHS 170

  Fly   171 VLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARLKYDNLRYIKNEQREGLIRSRVIGAREAV 235
            ::.|||..|:.|||||||.|:...|:..|. :..||  :..:|.::.::||||||:|::||..|.
Human   171 IINRTPGSLIAEIILVDDFSEREHLKDKLE-EYMAR--FSKVRIVRTKKREGLIRTRLLGASMAR 232

  Fly   236 GDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLINADTFEY--TPSPLVRGGFNWGLHF 298
            |:||.|||||.|||..||.|||..|...:.|:..|:||:|:.:.|.|  .....:||.|:|.:::
Human   233 GEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYY 297

  Fly   299 RWENLPEGTLKVPE----DFRGPFRSPTMAGGLFAVNRKYFQHLGEYDMAMDIWGGENIEISFRA 359
            :...:|      ||    |...||.||.||||||||:||:|..||.||..::|||||..||||:.
Human   298 KRIPIP------PELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKV 356

  Fly   360 WQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVWMDQYKDYYLKHEKVPKTYDY 424
            |.|||.:..|||||||||:||..||..|.| .::.:|..|:|..|||::.:|..:.....:....
Human   357 WMCGGEMFDVPCSRVGHIYRKYVPYKVPSG-TSLARNLKRVAETWMDEFAEYIYQRRPEYRHLST 420

  Fly   425 GDISDRLKLRERLQCRDFAWYLKNV---YPELHVPGEESKKSAAAPIFQPWHSRKRNYVDTFQLR 486
            ||||.:.:||::|:|:||.|::..|   .|:.:.|.|        |....|.          ::|
Human   421 GDISAQKELRKQLKCKDFKWFMAAVAWDVPKYYPPVE--------PPPAAWG----------EIR 467

  Fly   487 LTGTELCAAVVAPKVKGFWKKGSSLQLQTCRRTPNQLWYETEK------------AEIVLDKLLC 539
            .....||   |..|   ....|:.|:|..|.:..::..:..|:            .|.:..:..|
Human   468 NVAANLC---VDSK---HGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFC 526

  Fly   540 LEA-SGDAQVTVNKCHEMLGDQQW--RHTRNANSPVYNMAKGTCL 581
            .:| |.::.||:..||.|.|:|.|  |..|....||.|    :|:
Human   527 FDAISHNSPVTLYDCHGMKGNQLWGYRKDRTLFHPVSN----SCM 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	133/307 (43%)
		RICIN	489..610	CDD:214672	27/107 (25%)
		RICIN	490..609	CDD:238092	27/106 (25%)
GALNTL6	XP_016863733.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810