DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant35A and Galnt11

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001258248.1	Gene:	Galnt11 / 311952	RGDID:	735097	Length:	609	Species:	Rattus norvegicus

Alignment Length:	609	Identity:	261/609 - (42%)
Similarity:	358/609 - (58%)	Gaps:	67/609 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RLLCKSCGLGTLLVAVVWLLALLFY------SHSLRS-SIRSAGWRIDEGNATPRAEL--SYQAR 61
            |..|..|    |..:..|.:.|..|      :..||: .|:.:|         |....  .:..|
  Rat     8 RYFCYGC----LFTSATWTVLLFIYFNFSEVTQPLRNVPIKGSG---------PHGPFPKKFYPR 59

  Fly    62 VTVG----CTP-----------NASITTGESPAAPKPPSDPEQLELLGVVRNKQDKYIRDIGYKH 111
            .|.|    ..|           |.:|   |.|......|..|    ||::.|::|:.:||:||:.
  Rat    60 FTRGPGRVLEPQFKANRMDDLMNNNI---EDPDKGLSKSSSE----LGMIFNERDQELRDLGYQK 117

  Fly   112 HAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAENLPQASIVMCFYNEHKMTLMRSIKTVLERTP 176
            ||||.|:||.:|..|.:||||:..|  :..:...:||.||:|:|||||....|:|::.:|::|||
  Rat   118 HAFNMLISNRLGYHRDVPDTRNAEC--RGKSYPTDLPTASVVICFYNEAFSALLRTVHSVVDRTP 180

  Fly   177 SYLLREIILVDDHSDLP----ELEFHLHGDLRARLKYDNLRYIKNEQREGLIRSRVIGAREAVGD 237
            ::||.|||||||.||..    ||:.::...|.|::|     .|:|.:||||||.|:|||..|.|:
  Rat   181 AHLLHEIILVDDSSDFDDLKGELDEYIQRYLPAKVK-----VIRNMKREGLIRGRMIGAAHATGE 240

  Fly   238 VLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLINADTFEYTPSPLVRGGFNWGLHFRWEN 302
            ||||||||.|||..||:|||.:|..:..|:..||||:|:|||..|:.||:|||||||||||:|:.
  Rat   241 VLVFLDSHCEVNVMWLQPLLAIILEDPHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDL 305

  Fly   303 LPEGTLKVPEDFRGPFRSPTMAGGLFAVNRKYFQHLGEYDMAMDIWGGENIEISFRAWQCGGAIK 367
            :|...|...:....|.|||||||||||:||:||..||:||..||||||||:|||||.|.|||.:.
  Rat   306 VPVSDLGGADSATAPIRSPTMAGGLFAMNRQYFNDLGQYDSGMDIWGGENLEISFRIWMCGGKLF 370

  Fly   368 IVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVWMDQYKDYYLKHEKVPKTYDYGDISDRLK 432
            |:|||||||||||||||.||:|.:||..|||||||||:|:||:.|.......||..:|:||:|::
  Rat   371 IIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSFGNISERVE 435

  Fly   433 LRERLQCRDFAWYLKNVYPELHVPGEESKKSAAAPIFQPWHSRKRNYVDTFQLRLTGTELCAAVV 497
            ||::|.|:.|.|||.|||||:.|.|.:::  ...|:|.....::...:...:|....|..|  :|
  Rat   436 LRKKLGCQSFKWYLDNVYPEMQVSGPKAR--LQQPVFINRGPKRPRVLLRGRLYHLQTNKC--LV 496

  Fly   498 APKVKGFWKKGSSLQLQTC-RRTPNQLWYETEKAEIVLDKLLCLEAS---GDAQVTVNKCHEMLG 558
            |.....  :||..:.|:.| ...|.|:|...|:.|::|:.||||:.|   ......:.|||...|
  Rat   497 AQGRSS--QKGGLVLLKACDYGDPTQVWIYNEEHELILNNLLCLDMSETRSSDPPRLMKCHGSGG 559

  Fly   559 DQQWRHTRNANSPVYNMAKGTCLR 582
            .|||  |...|:.:|.::.|.|||
  Rat   560 SQQW--TFGKNNRLYQVSVGQCLR 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	172/302 (57%)
		RICIN	489..610	CDD:214672	33/98 (34%)
		RICIN	490..609	CDD:238092	33/97 (34%)
Galnt11	NP_001258248.1	pp-GalNAc-T	155..453	CDD:133004	172/302 (57%)
		Glyco_tranf_2_3	155..383	CDD:290369	133/232 (57%)
		Ricin_B_lectin	484..605	CDD:279046	34/104 (33%)
		RICIN	488..607	CDD:238092	33/100 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I2986
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11126
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1520
OMA	1	1.010	-	-		QHG50170
OrthoDB	1	1.010	-	-		D367513at33208
OrthoFinder	1	1.000	-	-		FOG0006575
OrthoInspector	1	1.000	-	-		oto97383
orthoMCL	1	0.900	-	-		OOG6_108745
Panther	1	1.100	-	-	LDO	PTHR11675
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840