DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant35A and Galnt18

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001073353.1	Gene:	Galnt18 / 293181	RGDID:	1309623	Length:	607	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	175/557 - (31%)
Similarity:	274/557 - (49%)	Gaps:	89/557 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 ESPAAP-----KPPSDPEQLELLGVVRNKQDKYIRDIGYKHHAFNALVSNNIGLFRAIPDTRHKV 135
            |:||.|     :|.:|.......|...:.:.:.:....::::.:||.:|:.:.|.|.:||.|...
  Rat    79 EAPAKPEEAEAEPFTDSSLFAHWGQELSPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLRPSG 143

  Fly   136 CDRQETTEAENLPQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHL- 199
            |  :..:..::||:.|||..|.||....|:|||.:.:|||||:||:|||||||:|...||:..|
  Rat   144 C--RNLSFPDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPSHLLKEIILVDDNSSNEELKEKLT 206

  Fly   200 -HGDLRARLKYDNLRYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSE 263
             :.|.....|...::.:::.::||||||||.|.|.|...|:...|:|:|.|..|.||:|..||..
  Rat   207 EYVDKVNGQKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKEN 271

  Fly   264 NATLAVPVIDLINADTFEYTPSPLVRGGFNWGLHFRWENLPEGTLKVPEDFRGPFRSPTMAGGLF 328
            ...:..|..|.|..|.||....||...||:|.|..|:.|.|:...|: |:...|.|||.:. |.|
  Rat   272 RKRIISPSFDNIKYDNFEIEEYPLAAQGFDWELWCRYLNPPKAWWKL-ENSTAPIRSPALI-GCF 334

  Fly   329 AVNRKYFQHLGEYDMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTM 393
            .|:|:||:.:|..|..|:::||||:|:..|.|||||:::::||||:.||.|..:|||. |....:
  Rat   335 IVDRQYFEEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYTE-DLTAHV 398

  Fly   394 LKNSLRLAHVWMDQYKDYYLKHEKVPKT---YDYGDISDRLKLRERLQCRDFAWYLKNVYPELHV 455
            .:|:||:|.||||::|.:......:|:.   .|.|||:.|..||::|||:.|.|||.:||||:.:
  Rat   399 RRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYPEMRM 463

  Fly   456 PG------------------EESKKSAAAPIFQPWHS---RKRNYVDTFQLRL------------ 487
            ..                  ::...:...||....|.   :...|..:.|:.:
  Rat   464 YSDIIAYGVLQNSLKTDLCFDQGPDTENVPIVYICHGMTPQNVYYTSSQQIHVGVLSPTIDDDDN 528

  Fly   488 -------TGTEL--CAAVVAPKVKGFWK--KGSSLQLQTCRRTPNQLWYETEKAEIVLDKLLCLE 541
                   :...|  |:...|.::|..|:  :|.|:|.:..:|                    |||
  Rat   529 RCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGSIQNRKSKR--------------------CLE 573

  Fly   542 ASGDA------QVTVNKCHEMLGDQQWRHTRNANSPV 572
            ...::      |:.:.||    ..|.|..|....|.|
  Rat   574 LQENSDMEFGFQLVLQKC----SGQHWTITNVLRSLV 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	128/303 (42%)
		RICIN	489..610	CDD:214672	20/94 (21%)
		RICIN	490..609	CDD:238092	20/93 (22%)
Galnt18	NP_001073353.1	pp-GalNAc-T	157..458	CDD:133004	128/303 (42%)
		Ricin_B_lectin	469..596	CDD:279046	21/150 (14%)
		RICIN	471..598	CDD:238092	22/150 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810