Protein Alignment Pgant35A and GALNT8

DIOPT Version :9

• Sequence 1: NP_652069.2
• Gene: Pgant35A / 48775
• FlyBaseID: FBgn0001970
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_059113.1
• Gene: GALNT8 / 26290
• HGNCID: 4130
• Length: 637
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 177/535 - (33%)
• Similarity: 268/535 - (50%)
• Gaps: 71/535 - (13%)

  Fly   100 QDKYIRDIGYKHHAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAENLPQASIVMCFYNEHKMTL 164
            |.|..:|: ::...:||.:||.:.|.|.|||||...|.|:  |....||..|:::.|.||....:
Human   136 QQKAAQDL-FRKFGYNAYLSNQLPLNRTIPDTRDYRCLRK--TYPSQLPSLSVILIFVNEALSII 197

  Fly   165 MRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARL---KYDN-LRYIKNEQREGLIR 225
            .|:|.:::.||||.||:|||||||.|...||:.||  |.:.:|   ||.. |:.|::.:|:||.:
Human   198 QRAITSIINRTPSRLLKEIILVDDFSSNGELKVHL--DEKIKLYNQKYPGLLKIIRHPERKGLAQ 260

  Fly   226 SRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLINADTFEYTPSPLVRG 290
            :|..|...|..||:..||:|||||..|.||:|..|:.:...:..||.|.|..|||:.....|...
Human   261 ARNTGWEAATADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKLDKYELAVD 325

  Fly   291 GFNWGLHFRWENLPEGTLKVPEDFRGPFRSPTMAGGLFAVNRKYFQHLGEYDMAMDIWGGENIEI 355
            ||||.|..|::.||:..:.: .|...|.:||::. |:.|.||.:...:|..|..|.|:||||:|:
Human   326 GFNWELWCRYDALPQAWIDL-HDVTAPVKSPSIM-GILAANRHFLGEIGSLDGGMLIYGGENVEL 388

  Fly   356 SFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVWMDQYKDYYLKHEKVP- 419
            |.|.|||||.::|:||||:.|:.|..:|| :.|....:.:|:||:|.:|||::|........:|
Human   389 SLRVWQCGGKVEILPCSRIAHLERHHKPY-ALDLTAALKRNALRVAEIWMDEHKHMVYLAWNIPL 452

  Fly   420 --KTYDYGDISDRLKLRERLQCRDFAWYLKNVYPELHVPGEESKKSAAAPIFQPWHS-----RKR 477
              ...|:||:|.|:.|||:|:|:.|.|||||||                |:.:|.|:     |.:
Human   453 QNSGIDFGDVSSRMALREKLKCKTFDWYLKNVY----------------PLLKPLHTIVGYGRMK 501

  Fly   478 NYVDTFQLRLTGTELCAAVVAPKVKGFWKKGSSLQLQTCRRTPNQLWYETEKAEIVLDKLL---- 538
            |.:|         |.......|      ..|::..:..|....:|..|.....|:.:.:|:
Human   502 NLLD---------ENVCLDQGP------VPGNTPIMYYCHEFSSQNVYYHLTGELYVGQLIAEAS 551

  Fly   539 ----CLEASGDAQ-VTVNKCHEMLGDQ---QWRHTRNANSPVYNMAKGTCLRAAAPTTGA-LISL 594
                ||...|.|: .|:..|.:...::   .|..  .....|.|.....||.......|: ::.|
Human   552 ASDRCLTDPGKAEKPTLEPCSKAAKNRLHIYWDF--KPGGAVINRDTKRCLEMKKDLLGSHVLVL 614

  Fly   595 DLCSKSNGAGGSWDI 609
            ..||..     .|:|
Human   615 QTCSTQ-----VWEI 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	125/305 (41%)
		RICIN	489..610	CDD:214672	25/134 (19%)
		RICIN	490..609	CDD:238092	24/131 (18%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		3/12 (25%)
		SMC_N	<48..>161	CDD:330553	8/25 (32%)
		GT1 motif	182..298		50/117 (43%)
		pp-GalNAc-T	184..485	CDD:133004	125/305 (41%)
		Gal/GalNAc transferase motif	358..397		18/39 (46%)
		RICIN	498..624	CDD:238092	27/147 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810