Protein Alignment Pgant35A and GALNT3

DIOPT Version :10

• Sequence 1: NP_652069.2
• Gene: Pgant35A / 48775
• FlyBaseID: FBgn0001970
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_004473.2
• Gene: GALNT3 / 2591
• HGNCID: 4125
• Length: 633
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 216/662 - (32%)
• Similarity: 333/662 - (50%)
• Gaps: 101/662 - (15%)

  Fly     1 MMQIKRLL---------CKSCGLGTLLVAVVWLLALLFYSHSLRSSIRSAGWRIDEGNATPRAEL 56
            |..:|||:         .|...||.::...:.:|.|:....|::.|...:....:..|.....:|
Human     1 MAHLKRLVKLHIKRHYHKKFWKLGAVIFFFIIVLVLMQREVSVQYSKEESRMERNMKNKNKMLDL 65

  Fly    57 SYQA---------RVTVGCTPNASITTGE-------------SPAAPKPPSDPE---------QL 90
            ..:|         ::.:|.....:|..||             .|...:||.|..         :.
Human    66 MLEAVNNIKDAMPKMQIGAPVRQNIDAGERPCLQGYYTAAELKPVLDRPPQDSNAPGASGKAFKT 130

  Fly    91 ELLGVVRNKQDKYIRDIGYKHHAFNALVSNNIGLFRAI-PDTRHKVCDRQETTEAENLPQASIVM 154
            ..|.|...|:    ::.|...|.|||..|:.|.|.|.: ||||...|..|:......||..|:::
Human   131 TNLSVEEQKE----KERGEAKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVII 191

  Fly   155 CFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARLK-YDNLRYIKNE 218
            .|:||...||:|::.:||..:|:.||:|||||||.|    ::.:||..|...:| :..::.::..
Human   192 VFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDAS----VDEYLHDKLDEYVKQFSIVKIVRQR 252

  Fly   219 QREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAV-PVIDLINADTFEY 282
            :|:|||.:|::||..|..:.|.|||:|.|....||||||..| :||.|..| |.|..|:.:|||:
Human   253 ERKGLITARLLGATVATAETLTFLDAHCECFYGWLEPLLARI-AENYTAVVSPDIASIDLNTFEF 316

  Fly   283 T-PSPL----VRGGFNWGLHFRWENLPEGTLKVPEDFRGPFRSPTMAGGLFAVNRKYFQHLGEYD 342
            . |||.    .||.|:|.|.|.||:||:...:..:|...|.::||.|||||:::::||:::|.||
Human   317 NKPSPYGSNHNRGNFDWSLSFGWESLPDHEKQRRKDETYPIKTPTFAGGLFSISKEYFEYIGSYD 381

  Fly   343 MAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVWMDQ 407
            ..|:||||||||:|||.|||||.::|:|||.|||:||.:.|::.|.|...:.:|.:|||.||||:
Human   382 EEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHSFPKGTQVIARNQVRLAEVWMDE 446

  Fly   408 YKDYYLKHE----KVPKTYDYGDISDRLKLRERLQCRDFAWYLKNVYPELHVPGEESKKSAAAPI 468
            ||:.:.:..    |:.|...:||:|.|.:::.||||::|.|||.|:|||::||
Human   447 YKEIFYRRNTDAAKIVKQKAFGDLSKRFEIKHRLQCKNFTWYLNNIYPEVYVP------------ 499

  Fly   469 FQPWHSRKRNYVDTFQLRLTGTELCAAVVAPKVKGFWKKGSSLQLQTCRRTPNQLWYETEKAEIV 533
                   ..|.|.:..::..|..||.. |....:|    |..|.:.||.......::|......:
Human   500 -------DLNPVISGYIKSVGQPLCLD-VGENNQG----GKPLIMYTCHGLGGNQYFEYSAQHEI 552

  Fly   534 ---LDKLLCLEASGDAQVTVNKC----HE--MLGDQQWRHTRNANSPVYNMAKGTCLRAAAPTTG 589
               :.|.|||.|: ...|.:..|    |:  :.|:|.|...:  :..:||.....||.|    .|
Human   553 RHNIQKELCLHAA-QGLVQLKACTYKGHKTVVTGEQIWEIQK--DQLLYNPFLKMCLSA----NG 610

  Fly   590 ALISLDLCSKSN 601
            ...||..|:.|:
Human   611 EHPSLVSCNPSD 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	136/309 (44%)
		beta-trefoil_Ricin_GALNT11	478..609	CDD:467318	33/133 (25%)
GALNT3	NP_004473.2	Catalytic subdomain A	184..293		46/112 (41%)
		pp-GalNAc-T	188..493	CDD:133004	136/309 (44%)
		Catalytic subdomain B	356..418		37/61 (61%)
		beta-trefoil_Ricin_GALNT3	502..630	CDD:467346	33/133 (25%)