Protein Alignment Pgant35A and GALNT1

DIOPT Version :10

• Sequence 1: NP_652069.2
• Gene: Pgant35A / 48775
• FlyBaseID: FBgn0001970
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_065207.2
• Gene: GALNT1 / 2589
• HGNCID: 4123
• Length: 559
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 205/529 - (38%)
• Similarity: 303/529 - (57%)
• Gaps: 48/529 - (9%)

  Fly    82 KPPSDPEQLELLGVVRNKQDKYIRDIGYKHHAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAEN 146
            ||...|.::....|:..:..:.:::: :|.:.||.:.|..|.|.|::||.|.:.|  :.....:|
Human    53 KPHEGPGEMGKPVVIPKEDQEKMKEM-FKINQFNLMASEMIALNRSLPDVRLEGC--KTKVYPDN 114

  Fly   147 LPQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARLKYDN 211
            ||..|:|:.|:||...||:|::.:|:.|:|.:::.||:||||.|:...|:..|...:: :||..
Human   115 LPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASERDFLKRPLESYVK-KLKVP- 177

  Fly   212 LRYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLIN 276
            :..|:.|||.||||:|:.||..:.|.|:.|||:|.|....||||||..||.:..|:..|:||:|:
Human   178 VHVIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGWLEPLLARIKHDRRTVVCPIIDVIS 242

  Fly   277 ADTFEY-TPSPLVRGGFNWGLHFRWENLPEGTL-KVPEDFRGPFRSPTMAGGLFAVNRKYFQHLG 339
            .||||| ..|.:..|||||.|:|||..:|:..: :...|...|.|:||||||||:::|.|||.:|
Human   243 DDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIG 307

  Fly   340 EYDMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTML-KNSLRLAHV 403
            .||..||||||||:|||||.|||||.::||.||.|||:|||..|||.|.|...:: ||:.|||.|
Human   308 TYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEV 372

  Fly   404 WMDQYKD-YYLKHEKVPKTYDYGDISDRLKLRERLQCRDFAWYLKNVYPELHVPGEESKKSAAAP 467
            |||::|: :|:....|.|. ||||||.|:.||.:|||:.|:|||:|:||:..:|
Human   373 WMDEFKNFFYIISPGVTKV-DYGDISSRVGLRHKLQCKPFSWYLENIYPDSQIP----------- 425

  Fly   468 IFQPWHSRKRNYVDTFQLRLTGTELCAAVVAPKVKGFWKKGSSLQLQTCR-RTPNQLWYETEKAE 531
                     |:|....::|...|..|...:|.      |:...:.:..|. ...||::..|...|
Human   426 ---------RHYFSLGEIRNVETNQCLDNMAR------KENEKVGIFNCHGMGGNQVFSYTANKE 475

  Fly   532 IVLDKLLCLEASG-DAQVTVNKCHEMLGDQQWRHTRNANSPV----YNMAKGTCLRAAAPTTGAL 591
            |..|. |||:.|. :..||:.|||.:.|:|.|.:     .||    .::....||..|......:
Human   476 IRTDD-LCLDVSKLNGPVTMLKCHHLKGNQLWEY-----DPVKLTLQHVNSNQCLDKATEEDSQV 534

  Fly   592 ISLDLCSKS 600
            .|:..|:.|
Human   535 PSIRDCNGS 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	150/302 (50%)
		beta-trefoil_Ricin_GALNT11	478..609	CDD:467318	33/129 (26%)
GALNT1	NP_065207.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..65		3/11 (27%)
		Catalytic subdomain A	115..225		48/111 (43%)
		pp-GalNAc-T	119..419	CDD:133004	150/302 (50%)
		Catalytic subdomain B	285..347		42/61 (69%)
		beta-trefoil_Ricin_GALNT1	426..552	CDD:467344	34/130 (26%)