DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant35A and Galnt9

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_938048.2	Gene:	Galnt9 / 231605	MGIID:	2677965	Length:	604	Species:	Mus musculus

Alignment Length:	535	Identity:	191/535 - (35%)
Similarity:	271/535 - (50%)	Gaps:	90/535 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 GVVRNKQD-------KYIRDIGYKHHAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAENLPQAS 151
            ||....||       |: .|.||     ||.:|:.|.|.|.|||.|.|.|  ::.|.:|:|||.|
Mouse    99 GVAATLQDDSQETEGKF-EDFGY-----NAQLSDRISLDRTIPDYRPKRC--RQITYSEDLPQIS 155

  Fly   152 IVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARLKYDNL-RYI 215
            :|..|.||....::||:.:|:..|||.||:|:|||||:||..||:|:|  |.....:|..| :.:
Mouse   156 VVFIFVNEALSVILRSVHSVVNHTPSQLLKEVILVDDNSDNVELKFNL--DQYVHKRYPGLVKVV 218

  Fly   216 KNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLINADTF 280
            :|.:||||||:|:.|.:.|...::.|.|:|:|.|..|.||.|..|:.:...:.:|.||.|...||
Mouse   219 RNSRREGLIRARLQGWKVATAPIVGFFDAHVEFNTGWAEPALARIQEDRRRIILPAIDNIKYSTF 283

  Fly   281 EYTPSPLVRGGFNWGLHFRWENLPEGTLKVPEDF--RG----PFRSPTMAGGLFAVNRKYFQHLG 339
            |.........|:||||...:       :..|:|:  ||    |.|:|.|.|..|.|:|:||..:|
Mouse   284 EVQQYASAAHGYNWGLWCMY-------IIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIG 341

  Fly   340 EYDMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVW 404
            ..|..|:::|.||||:..|.|||||:::::|||||.||.|.::||.: |......:|:||.|.||
Mouse   342 LLDPGMEVYGAENIELGMRVWQCGGSMEVLPCSRVAHIERTKKPYNN-DIDYYAKRNALRAAEVW 405

  Fly   405 MDQYKDYYLKHEKVPKT---YDYGDISDRLKLRERLQCRDFAWYLKNVYPELHV------PGEES 460
            ||.:|.:......:|.|   .|:||:|:||.|||:|:||.|.|||:|||||:.:      .||..
Mouse   406 MDDFKSHVYMAWNIPMTNPGVDFGDVSERLALREKLKCRSFKWYLENVYPEMRIYNNTLTYGEVR 470

  Fly   461 KKSAAA------------PIFQPWHSRKRNYV-----DTFQLRLTGTELCAAVVAPKVK-----G 503
            ...|:.            .|..|.|......|     ...||...|    :....|..|     |
Mouse   471 NSKASGYCLDQGAEDDDRAILYPCHGMSSQLVRYSAEGLLQLGPLG----STAFLPDSKCLVDDG 531

  Fly   504 FWKKGSSLQLQTCR---RTPNQLWYETEKAEIV-LDKLLCLEA--SGDA----QVTVNKCHEMLG 558
               :|....|:.|.   |...:||..|:...|| .|...|||.  |.||    ::.|.:|    .
Mouse   532 ---RGRMPTLKKCEDVARPTQRLWDFTQSGPIVSRDTGRCLEVEMSKDANFGLRLVVQRC----S 589

  Fly   559 DQQW------RHTRN 567
            .|:|      :|.|:
Mouse   590 GQKWMIRNWIKHARH 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	127/308 (41%)
		RICIN	489..610	CDD:214672	26/100 (26%)
		RICIN	490..609	CDD:238092	25/99 (25%)
Galnt9	NP_938048.2	pp-GalNAc-T	155..454	CDD:133004	127/308 (41%)
		Ricin_B_lectin	465..593	CDD:279046	32/138 (23%)
		RICIN	467..595	CDD:238092	33/138 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810