DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant35A and gly-6

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001022644.1	Gene:	gly-6 / 175558	WormBaseID:	WBGene00001631	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	641	Identity:	221/641 - (34%)
Similarity:	319/641 - (49%)	Gaps:	116/641 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LALLFYSH--------SLRSSIRSAGWRIDEGNATPRAELSYQARVTVGC-------TPNASITT 74
            |||:|.|.        |.:.:|:            |.|..:|  .|.||.       ....::|:
Worm    34 LALVFLSDMYIGEDQISTQKAIK------------PIARSNY--HVVVGHYNGNLPEDKKRNLTS 84

  Fly    75 GESPAAPKPPSD-------------PEQLELLGVVRNKQDKYIRDIGYKHHAFNALVSNNIGLFR 126
            .|..|....|.|             |||.:|            .|..:..:.||.|||:.|.:.|
Worm    85 EELNANLYAPHDDWGEGGAGVSHLTPEQQKL------------ADSTFAVNQFNLLVSDGISVRR 137

  Fly   127 AIPDTRHKVCDRQETTEAENLPQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHSD 191
            ::|:.|...|  :..|..:|||..|:::.::||...||:|::.:|::|:|..||:|||||||.||
Worm   138 SLPEIRKPSC--RNMTYPDNLPTTSVIIVYHNEAYSTLLRTVWSVIDRSPKELLKEIILVDDFSD 200

  Fly   192 LPELEFHLHGDLRARLK--YDNLRYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLE 254
               .||..:..|...||  ..:::.|::::|.||||:|::||:||.||||.|||||.|..:.|||
Worm   201 ---REFLRYPTLDTTLKPLPTDIKIIRSKERVGLIRARMMGAQEAQGDVLTFLDSHCECTKGWLE 262

  Fly   255 PLLRLIKSENATLAVPVIDLINADTFEYTPS-PLVRGGFNWGLHFRWENLPEGTLKVP-EDFRGP 317
            |||..||.....:..||||:||.:||:|... .:.||||||.|.|||..:|....|.. .|..||
Worm   263 PLLTRIKLNRKAVPCPVIDIINDNTFQYQKGIEMFRGGFNWNLQFRWYGMPTAMAKQHLLDPTGP 327

  Fly   318 FRSPTMAGGLFAVNRKYFQHLGEYDMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRR 382
            ..|||||||||::||.||:.|||||..||||||||:|:|||.|||||.::|:|||.|||:|||..
Worm   328 IESPTMAGGLFSINRNYFEELGEYDPGMDIWGGENLEMSFRIWQCGGRVEILPCSHVGHVFRKSS 392

  Fly   383 PYTSP--DGANTMLKNSLRLAHVWMDQYKDYYLKHEKVPKTYDYG---DISDRLKLRERLQCRDF 442
            |:..|  .....:..|.||:|.||||.:|.|:.|  ..|:.:...   |:|:|::||::|.|:.|
Worm   393 PHDFPGKSSGKVLNTNLLRVAEVWMDDWKHYFYK--IAPQAHRMRSSIDVSERVELRKKLNCKSF 455

  Fly   443 AWYLKNVYPELHVPGEESK-----KSAAAPIFQPWHSRKRNYVDTFQLRLTGTELCAAVVAPKVK 502
            .|||:||:.:..:|....:     .|:.:.:...|           .||.:|.:  .|..|..:|
Worm   456 KWYLQNVFQDHFLPTPLDRFGRMTSSSNSSVCLAW-----------TLRSSGIK--TASTADCLK 507

  Fly   503 GFWKKGSSLQLQTCRRTPNQLWYETEKAEIVLDKLLC------LEASGDAQVTVNKCHEMLGDQQ 561
            .|.|              .|||..|....|..|:.||      |..:.|.::.:.:|...  |.:
Worm   508 IFHK--------------TQLWLYTGDRRIRTDEHLCLSVVQLLHTTSDWKIQLKECAGF--DTE 556

  Fly   562 WRHTRNANSPVYNMAKGTCLRAA---APTTGALIS--LDLCSKSNGAGGSWDIVQL 612
            :...:.......|...|.||.:.   .||......  :..|..||.. .:|.|.::
Worm   557 YWDFKPKIGRFQNRKTGLCLASPDIFDPTKDEFNPPIVQKCRSSNDR-QNWTITEM 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	149/307 (49%)
		RICIN	489..610	CDD:214672	28/131 (21%)
		RICIN	490..609	CDD:238092	27/129 (21%)
gly-6	NP_001022644.1	WcaA	155..451	CDD:223539	145/300 (48%)
		pp-GalNAc-T	160..463	CDD:133004	149/307 (49%)
		Ricin_B_lectin	474..606	CDD:279046	31/161 (19%)
		RICIN	476..608	CDD:238092	32/161 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920