DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant35A and GALNTL5

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_016867282.1	Gene:	GALNTL5 / 168391	HGNCID:	21725	Length:	496	Species:	Homo sapiens

Alignment Length:	458	Identity:	192/458 - (41%)
Similarity:	263/458 - (57%)	Gaps:	65/458 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VWLLALLFYSHSLRSSIRSAGWRIDEGNATPRAELSYQARVTVGCTPNASITTGESPAAPKPPSD 86
            :|...|..|.|....|    .|:  :.:..|.:..|...:|      :..|..| |...|||.
Human    71 IWTALLFIYLHHNHVS----SWQ--KKSQEPLSAWSPGKKV------HQQIIYG-SEQIPKPH-- 120

  Fly    87 PEQLELLGVVRNKQDKYIRDIG--YKH-----------HAFNALVSNNIGLFRAIPDTRHKVCDR 138
                  :.|.|..:||....:|  :.|           :.||.::|.::|:.|.:||||.|:|.:
Human   121 ------VIVKRTDEDKAKSMLGTDFNHTNPELHKELLKYGFNVIISRSLGIEREVPDTRSKMCLQ 179

  Fly   139 QETTEAENLPQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHS---DLPE-LEFHL 199
            :.  ....||.||||:|||||....|.:::.:|...||.|.|.|||||||.|   ||.| |::||
Human   180 KH--YPARLPTASIVICFYNEECNALFQTMSSVTNLTPHYFLEEIILVDDMSKVDDLKEKLDYHL 242

  Fly   200 HGDLRARLKYDNLRYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSEN 264
            . ..|.::|     .|:|::||||||:|:|||..|.||||||||||.|||:.||||||..|..:.
Human   243 E-TFRGKVK-----IIRNKKREGLIRARLIGASHASGDVLVFLDSHCEVNRVWLEPLLHAIAKDP 301

  Fly   265 ATLAVPVIDLINADTFEYTPSPLVRGGFNWGLHFRWENL-------PEGTLKVPEDFRGPFRSPT 322
            ..:..|:||:|:..|.||.|||||||.|:|.|.|:|:|:       |||:.|       |.|||.
Human   302 KMVVCPLIDVIDDRTLEYKPSPLVRGTFDWNLQFKWDNVFSYEMDGPEGSTK-------PIRSPA 359

  Fly   323 MAGGLFAVNRKYFQHLGEYDMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKR--RPYT 385
            |:||:||:.|.||..:|:||..||.||.||:|:|.|.|.|||.:.|:||||||||.:|:  :|.|
Human   360 MSGGIFAIRRHYFNEIGQYDKDMDFWGRENLELSLRIWMCGGQLFIIPCSRVGHISKKQTGKPST 424

  Fly   386 SPDGANTMLKNSLRLAHVWMDQYKDYYLKHEKVPKTYDYGDISDRLKLRERLQCRDFAWYLKNVY 450
            .   .:.|..|.|||.|||:|:||:.:...:...|...||:|.:|::||:||.|:.|.|||.||:
Human   425 I---ISAMTHNYLRLVHVWLDEYKEQFFLRKPGLKYVTYGNIRERVELRKRLGCKSFQWYLDNVF 486

  Fly   451 PEL 453
            |||
Human   487 PEL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	153/311 (49%)
		RICIN	489..610	CDD:214672
		RICIN	490..609	CDD:238092
GALNTL5	XP_016867282.1	GT2	187..437	CDD:224137	133/265 (50%)
GALNTL5	XP_016867282.1	pp-GalNAc-T	190..486	CDD:133004	153/311 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152519
Domainoid	1	1.000	200	1.000	Domainoid score	I3040
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367513at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850