DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant35A and GALNT15

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_473451.3	Gene:	GALNT15 / 117248	HGNCID:	21531	Length:	639	Species:	Homo sapiens

Alignment Length:	677	Identity:	216/677 - (31%)
Similarity:	326/677 - (48%)	Gaps:	99/677 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMQIKRLLCKSCGLGTLLV-----AVVWLLALLF-YSHSLRSSIRS--------AGWRIDEG--- 48
            |:..||...:.|.|..||:     .|:.::|:|. ..|:|..::.:        |.:|:|.|
Human     1 MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTVTAQASKHSPEARYRLDFGESQ 65

  Fly    49 ----NATPRAELSYQARVTVGCTPNASITTGE---SPAAPKPPSDPEQLELLGVVR-----NKQD 101
                .|....|   :.....|..|..|:...:   :.|.|:...:..|....|..|     .:||
Human    66 DWVLEAEDEGE---EYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLIKQPRRQD 127

  Fly   102 KYI--RDIGYKH-----------------HAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAENL 147
            |..  ||.|...                 ......:|..|.|.||:|:.||.:|.:|.  ..::|
Human   128 KEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPLCLQQH--PQDSL 190

  Fly   148 PQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARLKYDNL 212
            |.||:::||::|...||:|::.::|:..|...|:|||||||.|...:|:..| .:..|||  :.:
Human   191 PTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKSAL-SEYVARL--EGV 252

  Fly   213 RYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLINA 277
            :.:::.:|.|.||:|::||..|.||||||:|:|.|.:..||||||..|..:.:.:..||||:|:.
Human   253 KLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDW 317

  Fly   278 DTFEYTPS-PLVRGGFNWGLHFRWENLPEGTLKVPEDFRGPFRSPTMAGGLFAVNRKYFQHLGEY 341
            .||:|.|| .|.||..:|.|.|.||.|||...|..:....|.|||.:.|.:.|::|.|||:.|.|
Human   318 KTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAY 382

  Fly   342 DMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVWMD 406
            |..|.:.||||:|:||:||.|||:::|:||||||||::.:..: ||......|:|.:|:|..|:.
Human   383 DSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQNQDSH-SPLDQEATLRNRVRIAETWLG 446

  Fly   407 QYKDYYLKHEKVPKTYDYG-----DISDRLKLRERLQCRDFAWYLKNVYPELHVPGEESKKSAAA 466
            .:|:.:.||.  |:.:...     |..:||:|:.||.||.|.|:|.||||||: |.|.
Human   447 SFKETFYKHS--PEAFSLSKAEKPDCMERLQLQRRLGCRTFHWFLANVYPELY-PSEP------- 501

  Fly   467 PIFQPWHSRKRNYVDTFQLRLTGTELCAAVVAPKVKGFWKKGSSLQLQTCRRTPNQLWYE-TEKA 530
               :|..|.|        |..||..|||...|   :|. ..|..:.|..|..:..|.:.: |.:.
Human   502 ---RPSFSGK--------LHNTGLGLCADCQA---EGD-ILGCPMVLAPCSDSRQQQYLQHTSRK 551

  Fly   531 EIVL--DKLLCLEASGDAQVTVNKCHE---MLGDQQWRHTRNANSPVYNMAKGTCLRAAAPTTGA 590
            ||..  .:.||. |....||.:..|.|   .:..|.|..  ..|..:.::..|.|:.|.......
Human   552 EIHFGSPQHLCF-AVRQEQVILQNCTEEGLAIHQQHWDF--QENGMIVHILSGKCMEAVVQENNK 613

  Fly   591 LISLDLCSKSNGAGGSWDIVQLKKPTE 617
            .:.|..|  ...|...|...|:....|
Human   614 DLYLRPC--DGKARQQWRFDQINAVDE 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	127/304 (42%)
		RICIN	489..610	CDD:214672	30/126 (24%)
		RICIN	490..609	CDD:238092	29/124 (23%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..155		9/48 (19%)
		Catalytic subdomain A	190..299		49/111 (44%)
		Glyco_tranf_2_3	191..447	CDD:290369	113/259 (44%)
		pp-GalNAc-T	194..493	CDD:133004	127/304 (42%)
		Catalytic subdomain B	358..420		35/61 (57%)
		Ricin_B_lectin	505..628	CDD:279046	33/139 (24%)
		RICIN	507..630	CDD:238092	33/139 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367513at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820