Protein Alignment Pgant35A and GALNT15

DIOPT Version :10

• Sequence 1: NP_652069.2
• Gene: Pgant35A / 48775
• FlyBaseID: FBgn0001970
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_473451.3
• Gene: GALNT15 / 117248
• HGNCID: 21531
• Length: 639
• Species: Homo sapiens
• Alignment Length: 677
• Identity: 216/677 - (31%)
• Similarity: 326/677 - (48%)
• Gaps: 99/677 - (14%)

  Fly     1 MMQIKRLLCKSCGLGTLLV-----AVVWLLALLF-YSHSLRSSIRS--------AGWRIDEG--- 48
            |:..||...:.|.|..||:     .|:.::|:|. ..|:|..::.:        |.:|:|.|
Human     1 MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTVTAQASKHSPEARYRLDFGESQ 65

  Fly    49 ----NATPRAELSYQARVTVGCTPNASITTGE---SPAAPKPPSDPEQLELLGVVR-----NKQD 101
                .|....|   :.....|..|..|:...:   :.|.|:...:..|....|..|     .:||
Human    66 DWVLEAEDEGE---EYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLIKQPRRQD 127

  Fly   102 KYI--RDIGYKH-----------------HAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAENL 147
            |..  ||.|...                 ......:|..|.|.||:|:.||.:|.:|.  ..::|
Human   128 KEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPLCLQQH--PQDSL 190

  Fly   148 PQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARLKYDNL 212
            |.||:::||::|...||:|::.::|:..|...|:|||||||.|...:|:..| .:..|||  :.:
Human   191 PTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKSAL-SEYVARL--EGV 252

  Fly   213 RYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLINA 277
            :.:::.:|.|.||:|::||..|.||||||:|:|.|.:..||||||..|..:.:.:..||||:|:.
Human   253 KLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDW 317

  Fly   278 DTFEYTPS-PLVRGGFNWGLHFRWENLPEGTLKVPEDFRGPFRSPTMAGGLFAVNRKYFQHLGEY 341
            .||:|.|| .|.||..:|.|.|.||.|||...|..:....|.|||.:.|.:.|::|.|||:.|.|
Human   318 KTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAY 382

  Fly   342 DMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVWMD 406
            |..|.:.||||:|:||:||.|||:::|:||||||||::.:..: ||......|:|.:|:|..|:.
Human   383 DSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQNQDSH-SPLDQEATLRNRVRIAETWLG 446

  Fly   407 QYKDYYLKHEKVPKTYDYG-----DISDRLKLRERLQCRDFAWYLKNVYPELHVPGEESKKSAAA 466
            .:|:.:.||.  |:.:...     |..:||:|:.||.||.|.|:|.||||||: |.|.
Human   447 SFKETFYKHS--PEAFSLSKAEKPDCMERLQLQRRLGCRTFHWFLANVYPELY-PSEP------- 501

  Fly   467 PIFQPWHSRKRNYVDTFQLRLTGTELCAAVVAPKVKGFWKKGSSLQLQTCRRTPNQLWYE-TEKA 530
               :|..|.|        |..||..|||...|   :|. ..|..:.|..|..:..|.:.: |.:.
Human   502 ---RPSFSGK--------LHNTGLGLCADCQA---EGD-ILGCPMVLAPCSDSRQQQYLQHTSRK 551

  Fly   531 EIVL--DKLLCLEASGDAQVTVNKCHE---MLGDQQWRHTRNANSPVYNMAKGTCLRAAAPTTGA 590
            ||..  .:.||. |....||.:..|.|   .:..|.|..  ..|..:.::..|.|:.|.......
Human   552 EIHFGSPQHLCF-AVRQEQVILQNCTEEGLAIHQQHWDF--QENGMIVHILSGKCMEAVVQENNK 613

  Fly   591 LISLDLCSKSNGAGGSWDIVQLKKPTE 617
            .:.|..|  ...|...|...|:....|
Human   614 DLYLRPC--DGKARQQWRFDQINAVDE 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	127/304 (42%)
		beta-trefoil_Ricin_GALNT11	478..609	CDD:467318	32/136 (24%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..155		9/48 (19%)
		Catalytic subdomain A	190..299		49/111 (44%)
		pp-GalNAc-T	194..493	CDD:133004	127/304 (42%)
		Catalytic subdomain B	358..420		35/61 (57%)
		beta-trefoil_Ricin_GALNT15	502..629	CDD:467320	34/143 (24%)