DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant35A and Galnt6

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001165534.1	Gene:	Galnt6 / 100361647	RGDID:	2319726	Length:	622	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	206/553 - (37%)
Similarity:	300/553 - (54%)	Gaps:	64/553 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 CTPNASITTGESPAAPKPPSDPEQLELLGVVRNKQDKYI-----RDIGYKHHAFNALVSNNIGLF 125
            |.|.........|...:||.||......|....|::..:     :|.|||.|.|||..|:.|.|.
  Rat    89 CLPGFYTPAELRPFWERPPQDPNSPGADGKAFQKKEWTLLETQEKDEGYKKHCFNAFASDRISLQ 153

  Fly   126 RAI-PDTRHKVCDRQETTEAENLPQASIVMCFYNEHKMTLMRSIKTVLERTPSYLLREIILVDDH 189
            |:: ||||...|..|:......||..|:|:.|:||...||:|::.:||..:|:.||:|||||||.
  Rat   154 RSLGPDTRPPECVDQKFRRCPPLPTTSVVIVFHNEAWSTLLRTVYSVLHTSPAILLKEIILVDDA 218

  Fly   190 SDLPELEFHLHGDL-RARLKYDNLRYIKNEQREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWL 253
            |    .:.||...| |...:...:|.::.::|:|||.:|::||..|..:||.|||:|.|....||
  Rat   219 S----TDEHLKEKLERYVQQLQIVRVVRQQERKGLITARLLGASVAQAEVLTFLDAHCECFHGWL 279

  Fly   254 EPLLRLIKSENATLAVPVIDLINADTFEYTPSPL------VRGGFNWGLHFRWENLPEGTLKVPE 312
            ||||..|..:...:..|.|..|:.:||::: .|:      .||.|:|.|.|.||.|||...:..:
  Rat   280 EPLLARIAEDKTAVVSPDIVTIDLNTFQFS-KPMRRGKAHSRGNFDWSLTFGWEMLPEHEKQRRK 343

  Fly   313 DFRGPFRSPTMAGGLFAVNRKYFQHLGEYDMAMDIWGGENIEISFRAWQCGGAIKIVPCSRVGHI 377
            |...|.:|||.|||||::::.||:|:|.||..|:||||||:|:|||.|||||.::|:|||.|||:
  Rat   344 DETYPIKSPTFAGGLFSISKAYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHV 408

  Fly   378 FRKRRPYTSPDGANTMLKNSLRLAHVWMDQYKDYY----LKHEKVPKTYDYGDISDRLKLRERLQ 438
            ||.:.|:|.|.|.:.:.:|.:|||.||||.||..:    |:..|:.|..::||:|:||:|||:|.
  Rat   409 FRTKSPHTFPKGTSVIARNQVRLAEVWMDDYKKIFYRRNLQAAKMAKENNFGDVSERLRLREQLH 473

  Fly   439 CRDFAWYLKNVYPELHVPGEESKKSAAAPIFQPWHSRKRNYVDTFQLRLTGTELCAAVVAPKVKG 503
            |.:|:|||.|||||:.||......|.|                   ::..||..|.. |....:|
  Rat   474 CHNFSWYLHNVYPEMFVPDLNPTFSGA-------------------IKNLGTSQCLD-VGENNRG 518

  Fly   504 FWKKGSSLQLQTCRRTPNQLWYE-TEKAEI--VLDKLLCLEASG------DAQVTVNKCHEMLGD 559
                |..|.:..|.......::| |.:.::  .:.|.|||.|||      :.|. :.|..|:..|
  Rat   519 ----GKPLIMYVCHNLGGNQYFEYTSQRDLRHNIGKQLCLHASGSTLGLRNCQF-IGKNSEVPKD 578

  Fly   560 QQWRHTRNANSPVYNMAKGTCLR------AAAP 586
            ::|..|:  :..:.|:..||||.      |.||
  Rat   579 EEWELTQ--DQLIRNLGSGTCLTSKDKKPAMAP 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	138/309 (45%)
		RICIN	489..610	CDD:214672	31/113 (27%)
		RICIN	490..609	CDD:238092	30/112 (27%)
Galnt6	NP_001165534.1	pp-GalNAc-T	180..485	CDD:133004	138/309 (45%)
Galnt6	NP_001165534.1	Ricin_B_lectin	497..619	CDD:395527	33/140 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920