DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant35A and galnt18b

DIOPT Version :9

Sequence 1:	NP_652069.2	Gene:	Pgant35A / 48775	FlyBaseID:	FBgn0001970	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_003199061.1	Gene:	galnt18b / 100310831	ZFINID:	ZDB-GENE-091014-1	Length:	609	Species:	Danio rerio

Alignment Length:	549	Identity:	178/549 - (32%)
Similarity:	268/549 - (48%)	Gaps:	116/549 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 RDIG----------YKHHAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAENLPQASIVMCFYNE 159
            :|:|          ::::.:|..:|:.:.:.|||||.|...|  :..:...||||.|||..|.||
Zfish   105 QDLGPESRRVALKMFQYYGYNGYLSDRLSMDRAIPDYRPDGC--KNMSYPSNLPQVSIVFIFVNE 167

  Fly   160 HKMTLMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARLKYDN------LRYIKNE 218
            ....::|||.:|:.||||:||:|||||||:|:..||:    ..|:..:|..|      ::.:::.
Zfish   168 ALSVILRSIHSVMNRTPSHLLKEIILVDDNSNNDELK----EKLQDFVKETNAKQPGFIKVVRHS 228

  Fly   219 QREGLIRSRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLINADTFEYT 283
            ::||||||||.|.|.|...|:...|:|:|.|..|.||:|:.||.:...:..|..|.|..||||..
Zfish   229 RQEGLIRSRVSGWRAASAPVVALFDAHVEFNIGWAEPILQRIKEDRTRIISPSFDNIKYDTFEIE 293

  Fly   284 PSPLVRGGFNWGLHFRWENLPEGTLKVPEDFRGPFRSPTMAGGLFAVNRKYFQHLGEYDMAMDIW 348
            ..||...||:|.|..|:.|.|:....: .:...|.|||.:. |.|.|:|.||..:|..|..|:|:
Zfish   294 EYPLSAQGFDWELWCRYLNPPKSWWNL-NNSTAPIRSPALI-GCFVVDRLYFAEIGLLDEGMEIY 356

  Fly   349 GGENIEISFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVWMDQYKDYYL 413
            ||||:|:..|.|||||:::::||:|:.||.|..:|||. |....:.:|:||:|.||||::|.:..
Zfish   357 GGENVELGVRVWQCGGSVEVLPCARIAHIERAHKPYTE-DLTAHVRRNALRVAEVWMDEFKSHVY 420

  Fly   414 KHEKVPKT---YDYGDISDRLKLRERLQCRDFAWYLKNVYPELHVPG------------------ 457
            ....:|:.   .|.|||::|..||::|||:.|.|||.|:|||:.:..
Zfish   421 MAWNIPQEDSGIDIGDIAERKALRKKLQCKTFRWYLVNIYPEMRMYTDTVAYGVLRNSLKTDLCL 485

  Fly   458 EESKKSAAAPIFQPWHS---RKRNYVDTFQL------------------------RLTGTELCAA 495
            ::...:...||....|.   :...|..|.||                        ||..   |:.
Zfish   486 DQGPDTDNIPILYLCHGMTPQNVYYTSTQQLFVGILSPTVDDDDNKCLVDVNGRPRLIE---CSY 547

  Fly   496 VVAPKVKGFWK--KGSSLQLQTCRRTPNQLWYETEKAEIVLDKLLCLE--ASGD----AQVTVNK 552
            .||.::|..|:  :|.|:|....:|                    |||  .:.|    .|:|:.|
Zfish   548 AVAKRMKLHWRFTQGGSIQNTKSKR--------------------CLELVENNDNEFGFQLTLQK 592

  Fly   553 CHEMLGDQQWRHTRNANSPVYNMAKGTCL 581
            |    ..|.|..|        ||..|:.|
Zfish   593 C----TGQNWTIT--------NMLPGSTL 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	127/307 (41%)
		RICIN	489..610	CDD:214672	24/101 (24%)
		RICIN	490..609	CDD:238092	24/100 (24%)
galnt18b	XP_003199061.1	pp-GalNAc-T	159..460	CDD:133004	127/307 (41%)
		Glyco_tranf_2_2	160..421	CDD:287123	110/267 (41%)
		Ricin_B_lectin	471..598	CDD:279046	27/153 (18%)
		RICIN	473..600	CDD:238092	28/153 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810