DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP2A1 and SERCA

DIOPT Version :9

Sequence 1:	NP_775293.1	Gene:	ATP2A1 / 487	HGNCID:	811	Length:	1001	Species:	Homo sapiens
Sequence 2:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster

Alignment Length:	989	Identity:	711/989 - (71%)
Similarity:	827/989 - (83%)	Gaps:	0/989 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRIL 65
            ||..|:||.|:.|.:||.....|||.||:|.|.:|||.||||.||||::|:||:|||:||||:||
  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65

Human    66 LLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVY 130
            ||||.||||||.|||.|||.||||||.||||||||||:||||||||||:|||||||||||||||.
  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130

Human   131 RADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVP 195
            |.|:..:|:::|::|||||:|||:||||:||||||..|.|||||:||||||||||||||||:.:|
  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195

Human   196 DPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQL 260
            |||||||||||:||||||:|||||.|:|..||:.|.|||||.:|:.||:.|||||||||||||||
  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260

Human   261 SKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |||||:||||||.|||||||||.|||||.:|||||||||||||||||||||||||||||||||||
  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

Human   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYA 390
            ||||||||||||||||||||||||||||||||||||||.:|||.|||:|:.....||.:|||||.
  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390

Human   391 PEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVF 455
            |.|||..|.:.::...||.|.||:|||.:||||::|:||.|..:|||||||||||..|.||:|.|
  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455

Human   456 NTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEG 520
            :.:...|.:...|.||...|....||||||||||||||||.||:|.|:||...|.|:||||||||
  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520

Human   521 VIDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFL 585
            |::||.:.|||||:||||..:|.||:|:..::|||||||||||||..|:|.|.:||.|.||.:|.
  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585

Human   586 EYETDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVAD 650
            :||.:|||||||||||||||||..||..||.||||||:||||||.||.|||||||:|.|:|:...
  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650

Human   651 RAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAE 715
            ::|:|||||||...||:.|..|:..|:||||.|||||||:|||.:||:|||||||||||||||||
  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715

Human   716 IGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA 780
            |||||||||||||:|:||||||||||:||:|||||||||||||||||||||||:||||.||||||
  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780

Human   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVG 845
            |||||||||||||||||||||||||||||||||||||::|||...|.||||||||||||||.|||
  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845

Human   846 AATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIEMC 910
            |||||||||||:::::||.::|.||||.:.|......|:|:||::|..|..|||||||||||||.
  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910

Human   911 NALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWLMVLKISL 975
            ||:|||||||||:.||||.|:||:||:.||.:|||:|||||.|..:|::..|...:|:.|:|.|:
  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975

Human   976 PVIGLDEILKFVAR 989
            ||:.|||.||||||
  Fly   976 PVVLLDETLKFVAR 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP2A1	NP_775293.1	Cation_ATPase_N	4..72	CDD:279080	41/67 (61%)
		ATPase-IIA1_Ca	53..989	CDD:273452	680/935 (73%)
		E1-E2_ATPase	93..340	CDD:278548	203/246 (83%)
		Cation_ATPase	419..528	CDD:289987	64/108 (59%)
		HAD	<611..712	CDD:289480	68/100 (68%)
		Cation_ATPase_C	784..987	CDD:279079	137/202 (68%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	788..808		19/19 (100%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	932..943		6/10 (60%)
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	707/983 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I1014
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7635
Inparanoid	1	1.050	1442	1.000	Inparanoid score	I114
Isobase	1	0.950	-	0	Normalized mean entropy	S832
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm41795
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	LDO	PTHR42861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3239
SonicParanoid	1	1.000	-	-		X745
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820