Protein Alignment NPM1 and Nlp

DIOPT Version :10

• Sequence 1: NP_002511.1
• Gene: NPM1 / 4869
• HGNCID: 7910
• Length: 294
• Species: Homo sapiens
• Sequence 2: NP_524557.1
• Gene: Nlp / 43560
• FlyBaseID: FBgn0016685
• Length: 152
• Species: Drosophila melanogaster
• Alignment Length: 195
• Identity: 51/195 - (26%)
• Similarity: 87/195 - (44%)
• Gaps: 57/195 - (29%)

Human    19 FGCELKADKD-YHFKVDNDENEHQ-LSLRTVSLGAGAKD-ELHIVEAEAMNYEGSPIKVTLATLK 80
            :|..|.|:.| ..:.||.|....| |.::.:.|||.||: |.::||   :|.....:::.:|.||
  Fly     7 YGVTLTAESDSVTWDVDEDYARGQKLVIKQILLGAEAKENEFNVVE---VNTPKDSVQIPIAVLK 68

Human    81 ----MSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGK 141
                .:|.|.|.....::|    .:|..|||||:|.|.::             ::||:::
  Fly    69 AGETRAVNPDVEFYESKVT----FKLIKGSGPVYIHGHNI-------------KDDVEVV----- 111

Human   142 RSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQK 206
                                     |.||||:|||..:|.:||..:::|.::.:.....|||.:|
  Fly   112 -------------------------DMEEDDEEDDVAEDEEDEHPKKRAKIENAADGKNAKNNKK 151

Human   207  206
              Fly   152  151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPM1	NP_002511.1	Required for interaction with SENP3	1..186		46/173 (27%)
		Necessary for interaction with APEX1. /evidence=ECO:0000269|PubMed:19188445	1..117		33/104 (32%)
		Nucleoplasmin	18..117	CDD:460792	33/104 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..247		18/87 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		0/4 (0%)
		Interaction with NOP2. /evidence=ECO:0000269|PubMed:8089149	187..215		5/20 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	191..197		0/5 (0%)
		Required for nucleolar localization	243..294
		NPM1-C	245..293	CDD:465081
Nlp	NP_524557.1	Nucleoplasmin	6..105	CDD:460792	33/117 (28%)