| Sequence 1: | NP_002511.1 | Gene: | NPM1 / 4869 | HGNCID: | 7910 | Length: | 294 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_651760.1 | Gene: | Nph / 43559 | FlyBaseID: | FBgn0039735 | Length: | 156 | Species: | Drosophila melanogaster |
| Alignment Length: | 188 | Identity: | 46/188 - (24%) |
|---|---|---|---|
| Similarity: | 75/188 - (39%) | Gaps: | 75/188 - (39%) |
- Green bases have known domain annotations that are detailed below.
|
Human 38 NEHQLSLRTVSLGAGAK-DELHIVEAEA-MNYEG--SPIKVTLATLKM----SVQPTVSLGGFEI 94
Human 95 TPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLA 159
Human 160 ADEDDDDD--DEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSK 215 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| NPM1 | NP_002511.1 | Required for interaction with SENP3 | 1..186 | 41/157 (26%) | |
| Necessary for interaction with APEX1. /evidence=ECO:0000269|PubMed:19188445 | 1..117 | 29/86 (34%) | |||
| Nucleoplasmin | 18..117 | CDD:460792 | 29/86 (34%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 120..247 | 17/98 (17%) | |||
| Nuclear localization signal. /evidence=ECO:0000255 | 152..157 | 1/4 (25%) | |||
| Interaction with NOP2. /evidence=ECO:0000269|PubMed:8089149 | 187..215 | 3/27 (11%) | |||
| Nuclear localization signal. /evidence=ECO:0000255 | 191..197 | 0/5 (0%) | |||
| Required for nucleolar localization | 243..294 | ||||
| NPM1-C | 245..293 | CDD:465081 | |||
| Nph | NP_651760.1 | Nucleoplasmin | 6..112 | CDD:460792 | 29/124 (23%) |
| Blue background indicates that the domain is not in the aligned region. | |||||