DRSC/TRiP Functional Genomics Resources

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Protein Alignment NPM1 and CG43902

DIOPT Version :10

Sequence 1:NP_002511.1 Gene:NPM1 / 4869 HGNCID:7910 Length:294 Species:Homo sapiens
Sequence 2:NP_572608.2 Gene:CG43902 / 31948 FlyBaseID:FBgn0264503 Length:1220 Species:Drosophila melanogaster


Alignment Length:324 Identity:73/324 - (22%)
Similarity:121/324 - (37%) Gaps:76/324 - (23%)


- Green bases have known domain annotations that are detailed below.


Human     1 MEDSMDMDMSPLRPQNYLFG--------CELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDEL 57
            :||::|.|  .:.|.|.  |        .::..|:|....:||||...:..:.| |........|
  Fly   358 IEDNLDND--EILPTNN--GEDEDDGDDADIDDDEDIKSAIDNDELAKKYPVAT-STTTKVPTTL 417

Human    58 HIVEAEAMNYEGSPIKVTLATLKMSVQP---TVSLGGFEITPPVVLRLK-------------CGS 106
            ...:..:.:...|....|:||...:..|   |.:......||.:..:||             .||
  Fly   418 ATSKTTSRSSSSSTTTTTMATSTTATSPSPSTTTTKPRTPTPTIGRKLKRNFFGLSQPETRYYGS 482

Human   107 GPVHISGQHLVAVEEDAESEDEEEEDV---------------KLLSISGKRSA--------PGGG 148
            ..:   |:.....:||..:|::::|:|               ||:|...::|.        ||  
  Fly   483 YDI---GRIRAQTQEDDTTEEKKDENVGELHYYDTSGGSSSRKLVSFDPEKSEENYLSTYYPG-- 542

Human   149 SKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTP-AKNAQKSNQNG- 211
                    |:.|.|......::......|||     .||::.||:||..:.| .|:.:|....| 
  Fly   543 --------KMNATEKKQQPTQQHATRYVDDD-----YAEQQPPVEKSKLENPWEKSEEKPEDAGQ 594

Human   212 -KDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSV-EDIKAKMQASIEKGGSLPKVEAKFINYVK 273
             :|.|..|...|..|:..:....||.....|||. |..||..::....|....|  .::.:|:|
  Fly   595 LEDGKLESDLESALQQYHEASTTTPTVTASPSSAFERFKALRRSRQRTGHKSHK--KRYKDYLK 656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPM1NP_002511.1 Required for interaction with SENP3 1..186 46/231 (20%)
Necessary for interaction with APEX1. /evidence=ECO:0000269|PubMed:19188445 1..117 29/139 (21%)
Nucleoplasmin 18..117 CDD:460792 23/122 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..247 38/153 (25%)
Nuclear localization signal. /evidence=ECO:0000255 152..157 0/4 (0%)
Interaction with NOP2. /evidence=ECO:0000269|PubMed:8089149 187..215 10/30 (33%)
Nuclear localization signal. /evidence=ECO:0000255 191..197 4/5 (80%)
Required for nucleolar localization 243..294 8/32 (25%)
NPM1-C 245..293 CDD:465081 7/29 (24%)
CG43902NP_572608.2 None

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