DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NPHS1 and nphs1

DIOPT Version :10

Sequence 1:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens
Sequence 2:XP_073779348.1 Gene:nphs1 / 692352 ZFINID:ZDB-GENE-051102-1 Length:1287 Species:Danio rerio


Alignment Length:1266 Identity:496/1266 - (39%)
Similarity:687/1266 - (54%) Gaps:106/1266 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    32 RGFWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHL 96
            :.|...|.|:||..||:..|:|.|.....||||.||||||||...:||:|||.:.||..:|::||
Zfish    72 QAFKTEPRNVTVRAGATALLKCEVLRASGAVQWVKDGLLLGPLRSLPGYPRYSMTGDQKKGQYHL 136

Human    97 HIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVP---PKLLLLTPEAGTMVTWVAGQEYVV 158
            .|....|.||..|||||||||....:||..|.|::.:|   |...|.:.|     .||.|::|.|
Zfish   137 QILDVTLEDDGPYECQVGRSESSRPIVSRTVWLNVQIPSSQPYFQLESEE-----PWVEGEQYTV 196

Human   159 NCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPA 223
            .|::.||||..:||:...|:.:.:..:....|||.||....|...:..||||:.:.|.|.|.:||
Zfish   197 TCIAPDAKPPAEITMFRDGEELLESESYTMSGSQDKLQNTHAEVTIRARSSDDTRRLTCRAKNPA 261

Human   224 LEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTA 288
            ....::...|:.|.|||..|:|  .||:...|:||..|::.|::.||||||||.|.|||:.:||:
Zfish   262 SPRALETGMTMKVYFPPQAPMI--MGLENEEVKAGSFLKVVCMSYGGNPLATLHWTKNGEVLSTS 324

Human   289 WGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTE 353
            |..:.....|.|||.|.|:|||:.|.|.|::.|.|:........||.|.|.|:.:.:|||....|
Zfish   325 WDVDFVSRRASSVLKMEVKPEDNHAVLQCQSINQVTRSPMSLTRTLTVLFEPAEVTLLGSFEAVE 389

Human   354 NKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCE 418
            .:.:.|||.:.||.|.|.:|||||:::|...|.|..:|.:||.:::||||....||||||:|.||
Zfish   390 GEEINLSCSTSSSNPPVHIRWWLGFKELNRTEVTFAEGDNGGMMTVSNLTHKVSREDNGLSLQCE 454

Human   419 AFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSR 483
            ||::. |:.:..::..|.|.||.||:|::.||....|.:|:.:||||.:.||||...|.|.|:::
Zfish   455 AFNKG-TRFSSVRAAELIVYYPPQKVWLDAPPPNVFLHSGSTLRLVCFSSGGNPTGQLTWLKNNK 518

Human   484 TV-TESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQ-----LSASTQLAVQ 542
            .| |.|:.....|.|            ||||:|:..||||.|.:.|.:..     ||..|:..|.
Zfish   519 VVLTASKQVSSERGV------------SRELLLILHPSDNLATYRCDSSNKAKKVLSTQTKFRVL 571

Human   543 FPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARS 607
            ||..:|.|:|....||.|..|:|.|::.||||..|:||......|:||...|:||.|.|.:....
Zfish   572 FPAVSVKIVAKQKELRRGQTLDLDCLAGSSNPTANISWSLGPVILKGVDQAPKRAEFGGMSRTSK 636

Human   608 VLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSA 672
            :.|.:.|....:|:||:|.|..|.|.|::||.|:||:.|||..||...|..:|...|.||..|||
Zfish   637 LSLTLESHHWRKRITCQAFSNVLSEGVNNFYSLDVLFPPEFSDEQPDEVQVIEDETATLPAKVSA 701

Human   673 NPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVH 737
            ||......|.|:|.:|.....||: ..|...|.:.||:|.|.|.|.:.|.|:||:...:|||||.
Zfish   702 NPDEITCEWIFQGEKLVKERDPRY-TFSDWTLEIVNVSRRDGGDYIIECSNAEGSNRTKLRLDVQ 765

Human   738 YAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLR 802
            |:||:|...||..||:|.:.|::|..|||||...||:|:.:||.|.|:..::.|.   ..||.|.
Zfish   766 YSPTVRMKSDPVFVNIGDTADLLCVADANPITSSMFSWKWMGEGERDELGEESED---DGTGVLT 827

Human   803 IHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARG 867
            |:.....:||.|||..|||::|......:|:|||||.::......|||:.||.::.|.:.|:|:|
Zfish   828 IYEVTRDRAGVYQCTADNGISPTGSVEGQLIVRFAPDLQKGPQWRKVASRGDGSNDANVVCQAQG 892

Human   868 VPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTN 932
            ||.:.|.|.|||.||||.:|||.|.|...|.:|:|:||:.|||||.|||:|||||.|::|.|..:
Zfish   893 VPRVQFRWAKNGFPLDLGNPRYEETTESTGTIHTSILTVINVSAALDYAIFTCTAHNSMGEDSLD 957

Human   933 IQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATT 997
            |||:|.:.|||||.||::.:...||.|||.|||||||.|.|.:||:..|:..:.||||.||.||.
Zfish   958 IQLLSTNHPDPPSDLKLLRVDQTSVTLEWMPGFDGGLTQIFRVRYQWAGSASYMYVDVFPPTATV 1022

Human   998 FTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSG--EPEDQLPTEPPSGPSGL 1060
            :|:|||.|||.|...:.|.|::|:|..||....|.:||....:..|  ...||   :......||
Zfish  1023 YTVTGLNPSTMYNFSVNALNSIGESSYADNNKILMVTTADAKEADGGVSTADQ---DSALAGGGL 1084

Human  1061 PL-LPVLFALGGLLLLSNA-SCVGGVLWQRR--LRRLAEGISEKTEAGSEEDRVRNEYEESQWTG 1121
            |: :.|:..:||:|.|.|. .|.....|:||  |:.....||::|:  |||.  |:....|....
Zfish  1085 PVYVVVILVVGGVLFLLNPFICFLLARWKRRRSLKGDTSSISQETK--SEEQ--RSTASSSTRYA 1145

Human  1122 ERD-----TQSSTVSTTEAEP---------------YYRSLRDFSPQL---PPTQEEVSYSRG-- 1161
            .|:     .|.:.:..:.:||               ||.....:||.|   |...|:.....|  
Zfish  1146 SRELINASAQRTLLVDSSSEPDSSVYESYGRQENPHYYYPTEAYSPALYAHPEGPEDYDGRHGTS 1210

Human  1162 -FTGEDEDMAFPGHLYDEVERTYPPSGAWGPLYDEVQMGPWDLHWPEDTYQDPR----------- 1214
             ||          |:|:||...|....|..||.....:.|   ..|..||.:.|           
Zfish  1211 PFT----------HVYEEVRGMYEDLQACSPLPPAAHIHP---QAPFSTYYEGRAYSKADVDVTI 1262

Human  1215 GIYDQVA----GDLDTLEPDSLPFELRGHLV 1241
            |.||.:.    .|.|      |||||||.||
Zfish  1263 GAYDSMVYRRRRDTD------LPFELRGELV 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPHS1NP_004637.1 V-set 38..119 CDD:462230 44/80 (55%)
C2-set_2 141..228 CDD:400489 29/86 (34%)
Ig strand B 156..160 CDD:409353 2/3 (67%)
Ig strand C 170..174 CDD:409353 2/3 (67%)
Ig strand E 200..204 CDD:409353 1/3 (33%)
Ig strand F 214..219 CDD:409353 2/4 (50%)
Ig strand G 229..232 CDD:409353 0/2 (0%)
Ig 237..336 CDD:472250 43/98 (44%)
Ig strand B 261..265 CDD:409353 1/3 (33%)
Ig strand C 275..279 CDD:409353 2/3 (67%)
Ig strand E 300..304 CDD:409353 3/3 (100%)
Ig strand F 314..319 CDD:409353 2/4 (50%)
Ig strand G 332..335 CDD:409353 1/2 (50%)
Ig 345..424 CDD:472250 37/78 (47%)
Ig strand B 357..361 CDD:409353 1/3 (33%)
Ig strand C 371..375 CDD:409353 1/3 (33%)
Ig strand E 400..404 CDD:409353 3/3 (100%)
Ig strand F 414..419 CDD:409353 2/4 (50%)
Ig strand G 430..433 CDD:409353 0/2 (0%)
Ig 446..541 CDD:472250 34/100 (34%)
Ig strand B 461..465 CDD:409353 2/3 (67%)
Ig strand C 475..479 CDD:409353 1/3 (33%)
Ig strand E 510..515 CDD:409353 4/4 (100%)
Ig strand F 525..530 CDD:409353 1/4 (25%)
Ig 549..632 CDD:472250 31/82 (38%)
Ig strand B 563..567 CDD:409353 2/3 (67%)
Ig strand C 577..581 CDD:409353 2/3 (67%)
Ig strand E 606..610 CDD:409353 0/3 (0%)
Ig strand F 620..625 CDD:409353 3/4 (75%)
Ig strand G 635..638 CDD:409353 0/2 (0%)
Ig 646..736 CDD:472250 36/89 (40%)
Ig strand B 664..668 CDD:409353 2/3 (67%)
Ig strand C 678..682 CDD:409353 0/3 (0%)
Ig strand E 702..706 CDD:409353 1/3 (33%)
Ig strand F 716..721 CDD:409353 1/4 (25%)
Ig strand G 729..732 CDD:409353 0/2 (0%)
Ig_3 740..820 CDD:464046 32/79 (41%)
IgC1_hNephrin_like 834..942 CDD:143250 55/107 (51%)
putative Ig strand A 839..844 CDD:143250 0/4 (0%)
putative Ig strand B 859..866 CDD:143250 2/6 (33%)
putative Ig strand C 870..876 CDD:143250 1/5 (20%)
putative Ig strand C' 879..881 CDD:143250 1/1 (100%)
putative Ig strand D 888..891 CDD:143250 2/2 (100%)
putative Ig strand E 898..906 CDD:143250 3/7 (43%)
putative Ig strand F 917..924 CDD:143250 5/6 (83%)
putative Ig strand G 939..942 CDD:143250 0/2 (0%)
FN3 941..1022 CDD:238020 43/80 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 8/33 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137 8/42 (19%)
Binds to NPHS2 1160..1241 28/98 (29%)
nphs1XP_073779348.1 None

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