DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPHS1 and sns

DIOPT Version :9

Sequence 1:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens
Sequence 2:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster

Alignment Length:	1287	Identity:	375/1287 - (29%)
Similarity:	584/1287 - (45%)	Gaps:	142/1287 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    11 LLLLGLLTEGLAQLAIPA-SVPRGFWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPD 74
            |.||.::.  ||...:|: :..:.|...|.:|.|:|||...:||.|:....||||.|||..||..
  Fly    52 LRLLAVIV--LASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFS 114

Human    75 PRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLL 139
            ..|||||||.:.||..:|.::|.|....::|||:|:||||.:         |:..:|....||.:
  Fly   115 AVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPA---------RLNSAIRANAKLTV 170

Human   140 LTPEAGTMVTWVA---------GQEYVVNCVSGDAKPAPDITILLSGQTISDISANVN------- 188
            ::|.|...:...:         .|:..:.|:..:||||..| :...|        ||.
  Fly   171 ISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQI-VWYRG--------NVEYKPEKRE 226

Human   189 ---EGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPAL--EAPIKASFTVNVLFPPGPPVIEWP 248
               |.|..|.||..::.::.|...|:.....|:|...||  :.|::|:..::||:|||||.||
  Fly   227 DTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIE-- 289

Human   249 GLDEGH-VRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHG 312
            |...|. :|.||::||.|.:|||||.|.|.|.|||..:..|:.|  :..::.::...|....|:.
  Fly   290 GYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRT--SGRLSENIYTFTAEAGDNK 352

Human   313 AQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLG 377
            |:..|||.|.:|....:..:.|.|.|.|:.:.::|.........|.|:|.:..|.|...::|.:|
  Fly   353 ARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVG 417

Human   378 WRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQ 442
            .||:.......:....||..:.||:|.:.......|.:.|...:...| |....:..:||.||..
  Fly   418 GRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLT-ENVVSTHTINVLYPPA 481

Human   443 KLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGS 507
            ...|.|..|||.:.||:..:|:|::.||||..:|.|||:.:.:.             ..:..:..
  Fly   482 PPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRIN-------------SVIRAADK 533

Human   508 TFSRELVLVTGPSDNQAKFTCKAGQ------LSASTQLAVQFPPTNVTILANASALRPGDALNLT 566
            :.|.|:.::...|||||::.|:|..      |..||.|:|.|.|..|.|......||||....:.
  Fly   534 SVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATII 598

Human   567 CVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELR 631
            |.|.|||||..|||.|:|..:||:....:...:.|:.:.....:.|:...:||..||::.:..|:
  Fly   599 CDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQ 663

Human   632 ETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEAL-LPVSVSANPAPEAFNWTFRGYRLSPAGGPR 695
            .:......|:|||||:|:.........|| ||:| :.:...|||.|..:.||..|..:...|.
  Fly   664 RSAHEAVSLDVLYRPKFVPPPSSTAVGVE-GESLQVSLQTRANPTPVTYKWTKDGTTIPQDGD-- 725

Human   696 HRILS-SGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDI 759
            |||.: .|:|:...:.|.|.|:|.....||:|.|...:.:.|.|..||:::.:...||.|....:
  Fly   726 HRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAML 790

Human   760 VCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAP 824
            .|||:..|:......|||:|   .|.::......:.| |..|.|..||....|.::|:.||.|..
  Fly   791 SCTVEGKPLTEEHVKWERVG---YDMTVKTSTTFANG-TSYLHIKDAKREDVGNFRCVADNRVDN 851

Human   825 PARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTW--TKNGVPL----- 882
            |..|.:.|:|:|||::. .|| |.:.||..:.....|.|||:|.|...|.|  .|..:|:
  Fly   852 PTNRDILLIVKFAPEIA-KTP-TLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYK 914

Human   883 -DLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSG 946
             ::::.:....||      .|.|.:..|:.| ||..:.|.|.|.||.....::|...|:||||..
  Fly   915 YEVEERKIDSLTY------ESTLIVDKVAPA-DYGAYECVARNELGEAVETVRLEITSQPDPPLS 972

Human   947 LKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRV 1011
            |.::::|..:|.|.|.|||||||...:.:||.......:.|:|.: |.:...|:.||:.:|.|..
  Fly   973 LNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGL-PNSHKLTIGGLRMNTLYLF 1036

Human  1012 WLLASNALGDSG-LADKGTQLPITTPGLHQPSGEPEDQLPTEPPS-------GPSGLPLLPVLFA 1068
            .:::.|.||.|. |.|.........|    |...|...|...||:       |.||:.|:.|  .
  Fly  1037 SVMSWNELGQSSYLPDLARAETKEAP----PPSHPASSLGGGPPTTSQTPLGGTSGMLLVGV--G 1095

Human  1069 LGGLLLLSNASCVGGVLWQRRLRRLAEGI----SEKTEAGSEEDR-------------VRNEYEE 1116
            .|.:::|.|...:|..|.:|..:||..|:    :|.||..|....             :......
  Fly  1096 AGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASL 1160

Human  1117 SQWTGERDTQSSTVSTTEAEPYYRSLRDFSPQLPPTQEEVSYSRGFTGEDEDMAFPGHLYDEVER 1181
            ..|......:.....||.......::..::|.        ||:...|||.....      .|...
  Fly  1161 VAWFFVHQRRKKVAETTNQPAKTATIEMYAPS--------SYNDTVTGETLSSV------SEKSE 1211

Human  1182 TYPPSGAWGPLY-DEVQMGPWDLHWPEDTYQDPRGIYDQVAGDLDTLEPDSL 1232
            :|...|:..|.| |||:......:..|.:...|...  |..|.|..:.|:::
  Fly  1212 SYSNEGSSQPEYIDEVRKKAASTYLVEGSDMPPPRY--QKDGTLPVIYPNNV 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPHS1	NP_004637.1	V-set	38..119	CDD:284989	38/80 (48%)
		IG_like	38..113	CDD:214653	35/74 (47%)
		C2-set_2	141..228	CDD:285423	23/107 (21%)
		Ig	240..321	CDD:299845	33/81 (41%)
		IG_like	254..336	CDD:214653	28/82 (34%)
		Ig	345..424	CDD:299845	17/78 (22%)
		Ig	445..530	CDD:299845	25/84 (30%)
		I-set	446..541	CDD:254352	30/100 (30%)
		Ig	549..632	CDD:299845	26/82 (32%)
		IG_like	558..642	CDD:214653	25/83 (30%)
		I-set	646..736	CDD:254352	28/91 (31%)
		Ig	662..736	CDD:299845	24/75 (32%)
		Ig_3	739..820	CDD:290638	22/80 (28%)
		IG_like	748..821	CDD:214653	21/72 (29%)
		Ig8_hNephrin_like	834..942	CDD:143250	34/115 (30%)
		IG_like	845..935	CDD:214653	27/97 (28%)
		fn3	942..1023	CDD:278470	28/80 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		7/50 (14%)
		Binds to NPHS2	1160..1241		17/74 (23%)
sns	NP_001036532.1	I-set	73..170	CDD:254352	43/105 (41%)
		Ig	76..155	CDD:299845	37/78 (47%)
		IG_like	186..279	CDD:214653	23/101 (23%)
		Ig	197..279	CDD:299845	22/90 (24%)
		IG_like	296..376	CDD:214653	28/81 (35%)
		Ig	300..361	CDD:299845	24/62 (39%)
		Ig	380..454	CDD:299845	16/73 (22%)
		IG_like	490..573	CDD:214653	28/95 (29%)
		Ig	501..560	CDD:299845	19/71 (27%)
		Ig	584..666	CDD:299845	25/81 (31%)
		IG_like	585..666	CDD:214653	25/80 (31%)
		I-set	678..767	CDD:254352	28/91 (31%)
		IGc2	692..757	CDD:197706	23/67 (34%)
		Ig	788..849	CDD:143165	19/64 (30%)
		Ig	885..960	CDD:143165	23/81 (28%)
		FN3	967..1051	CDD:238020	30/84 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8349
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20974
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1398
Isobase	1	0.950	-	0	Normalized mean entropy	S6746
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0005450
OrthoInspector	1	1.000	-	-		otm40325
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11640
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4392
SonicParanoid	1	1.000	-	-		X3304
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.910