DRSC/TRiP Functional Genomics Resources

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Protein Alignment NPHS1 and side

DIOPT Version :10

Sequence 1:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens
Sequence 2:NP_001247334.1 Gene:side / 43300 FlyBaseID:FBgn0016061 Length:986 Species:Drosophila melanogaster


Alignment Length:871 Identity:197/871 - (22%)
Similarity:302/871 - (34%) Gaps:229/871 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   407 RREDNGLT----------LTC----EAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRA 457
            |..|||.|          |||    ::.|.....:.|:|::      ||:.:|         ...
  Fly    55 RCPDNGKTIWAVGFTLVLLTCLQQLKSVSADEESQDFQKNI------PARLVW---------AAL 104

Human   458 GTRVRLVCLAIGGNPEPS---LMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTG- 518
            |..|.|.|.......:.|   |:|:||:..:....|......|.|.......|...:.|....| 
  Fly   105 GKTVELPCDLTPPTSQDSVKLLLWFKDTTGIPLYSLDSRGGNVKLAPHAAIASDLGQRLFFSIGD 169

Human   519 -PSDNQAK-----------FTCKAGQLSASTQ-----LAVQFPPTNVTIL--------ANASALR 558
             |.|::.:           :.|:....::.|:     |.:..||....|.        ..|...|
  Fly   170 NPKDSRLQINDVKPEDGGVYRCRVDFFNSPTRNFRHNLTLVVPPEEPRIFDAQGKEISQMAGPFR 234

Human   559 PGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAA-ARSVLLQVSSRD-HGQRV 621
            .|..|.|.|......||..::|.::...|.|.:   ..:..:|:.. ...:|:..::|| :|.|:
  Fly   235 EGYELFLCCQVRGGRPPPKVTWWRDDTELIGTS---HTSVEEGATVMVNQLLIGTTTRDFYGIRI 296

Human   622 TCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSV-----SANPAPEAFNW 681
            .|||....|.:.|.....:.|..:|    .:|.:.|..|...|..|:.:     .:.||.: ..|
  Fly   297 ECRAQGTRLVDPVRKDVTVQVYLKP----VRVKIATPNELLTAGQPMPIRCESWGSYPAAK-ITW 356

Human   682 TFRGYRLSPAGGPRHRILSSG----ALHLWNVTRADDGLYQLHCQN-----SEGTAEARLRLDVH 737
            ...|..:..|....|.....|    ::....||..:|.. :|.|:.     |.|..|.:..:.|.
  Fly   357 LLDGEPIRNAEVTVHSDKEDGNITTSILTLKVTSENDNA-ELTCRATNPWFSGGAIEDKRIIRVA 420

Human   738 YAPTIR---ALQDPTEVNV---GGSVDIVCTVDANPILPGMFNW-----ERLGEDEEDQSLDDME 791
            |.||:.   |.:||:.:..   |.:|...|..||.|.:.. ::|     ...||..|...|..:|
  Fly   421 YPPTVSVHLANEDPSRLVTRAEGQNVTFKCRADARPPVTS-YSWFKNGMRMSGESTEIMHLTQLE 484

Human   792 KISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDST 856
            :.|                ||||.|...|.........|.|.|:|:|:.:..|..|.:.|.  |.
  Fly   485 RES----------------AGAYACGATNTEGETRSSSLTLKVQFSPRCKSGTEQTSIGAV--SL 531

Human   857 SSATLHCRARGVP--NIVFTWTKNGV----PL---DLQDPRYTEHTYHQGGVHSSLLTIANVSAA 912
            .|..:.|.....|  ::.|:||.|..    |:   .:|.........:.....|.|:|:|     
  Fly   532 HSILVKCEVDADPPDSVRFSWTYNNTRNVSPVLNSRIQSNGLASTVTYLPQTDSELITLA----- 591

Human   913 QDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLE--WKPGFDGGLPQRFCI 975
                   |.|:||:|. ||...||.|...:.|...|...|...:| ||  ...|.||||.|.|.:
  Fly   592 -------CWASNAVGR-QTTPCLVHILPANTPEAPKACELRNDTV-LEVVCVAGSDGGLSQYFML 647

Human   976 RY-----------------------EALGTPGFHYVDVVPPQATT------------FTLTGLQP 1005
            ..                       ||:|. |.:.:..:..|||:            |.|..|:|
  Fly   648 EVVGGDPLYSGDPGGSAGQGRGQFSEAIGL-GDNEISTLNDQATSAPIFRMQENSPQFRLNNLEP 711

Human  1006 STRYRVWLLASNALGDSGLADKGTQLPITTP--------GLHQPSGEPEDQLPTEPP-------- 1054
            ...|:..:.|.||.|.|       :.|:...        |.:..|...||..|.|..        
  Fly   712 GREYQFLVYAVNAKGRS-------EPPVVIENVRVAAQLGPYDESILSEDPTPAETTHHGGGGVG 769

Human  1055 ---------------SGP---SGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGISE-- 1099
                           |||   |.|.:|..:..:|.:::.|  ..|.|::...|.|.......|  
  Fly   770 GSGSSSGLGTGASTGSGPEKQSTLLILAAVVVIGAVVVTS--IIVAGIVVVCRHRPRPPEPQEVR 832

Human  1100 ------KTEAGS---EEDRVRNEYEE 1116
                  :.:..|   |||.: ||.||
  Fly   833 KSMRPARNDVPSMYIEEDEL-NELEE 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPHS1NP_004637.1 V-set 38..119 CDD:462230
C2-set_2 141..228 CDD:400489
Ig strand B 156..160 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 200..204 CDD:409353
Ig strand F 214..219 CDD:409353
Ig strand G 229..232 CDD:409353
Ig 237..336 CDD:472250
Ig strand B 261..265 CDD:409353
Ig strand C 275..279 CDD:409353
Ig strand E 300..304 CDD:409353
Ig strand F 314..319 CDD:409353
Ig strand G 332..335 CDD:409353
Ig 345..424 CDD:472250 9/30 (30%)
Ig strand B 357..361 CDD:409353
Ig strand C 371..375 CDD:409353
Ig strand E 400..404 CDD:409353
Ig strand F 414..419 CDD:409353 4/18 (22%)
Ig strand G 430..433 CDD:409353 1/2 (50%)
Ig 446..541 CDD:472250 20/115 (17%)
Ig strand B 461..465 CDD:409353 2/3 (67%)
Ig strand C 475..479 CDD:409353 2/6 (33%)
Ig strand E 510..515 CDD:409353 1/4 (25%)
Ig strand F 525..530 CDD:409353 1/15 (7%)
Ig 549..632 CDD:472250 22/92 (24%)
Ig strand B 563..567 CDD:409353 2/3 (67%)
Ig strand C 577..581 CDD:409353 0/3 (0%)
Ig strand E 606..610 CDD:409353 0/3 (0%)
Ig strand F 620..625 CDD:409353 2/4 (50%)
Ig strand G 635..638 CDD:409353 0/2 (0%)
Ig 646..736 CDD:472250 21/103 (20%)
Ig strand B 664..668 CDD:409353 1/3 (33%)
Ig strand C 678..682 CDD:409353 0/3 (0%)
Ig strand E 702..706 CDD:409353 1/7 (14%)
Ig strand F 716..721 CDD:409353 1/4 (25%)
Ig strand G 729..732 CDD:409353 1/2 (50%)
Ig_3 740..820 CDD:464046 23/90 (26%)
IgC1_hNephrin_like 834..942 CDD:143250 30/116 (26%)
putative Ig strand A 839..844 CDD:143250 0/4 (0%)
putative Ig strand B 859..866 CDD:143250 1/6 (17%)
putative Ig strand C 870..876 CDD:143250 1/5 (20%)
putative Ig strand C' 879..881 CDD:143250 0/5 (0%)
putative Ig strand D 888..891 CDD:143250 0/2 (0%)
putative Ig strand E 898..906 CDD:143250 2/7 (29%)
putative Ig strand F 917..924 CDD:143250 2/6 (33%)
putative Ig strand G 939..942 CDD:143250 0/2 (0%)
FN3 941..1022 CDD:238020 29/117 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 8/62 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137 9/29 (31%)
Binds to NPHS2 1160..1241
sideNP_001247334.1 V-set 95..211 CDD:462230 23/130 (18%)
Ig 211..301 CDD:472250 22/92 (24%)
Ig strand B 239..243 CDD:409353 2/3 (67%)
Ig strand C 253..257 CDD:409353 0/3 (0%)
Ig strand E 281..285 CDD:409353 1/3 (33%)
Ig strand F 295..300 CDD:409353 2/4 (50%)
Ig 326..408 CDD:472250 16/83 (19%)
Ig strand B 339..343 CDD:409353 0/3 (0%)
Ig strand C 353..357 CDD:409353 0/4 (0%)
Ig strand E 384..388 CDD:409353 0/3 (0%)
Ig strand F 396..401 CDD:409353 2/4 (50%)
Ig_2 442..511 CDD:464026 21/85 (25%)
FN3 <700..735 CDD:238020 11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

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