DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPHS1 and plum

DIOPT Version :9

Sequence 1:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens
Sequence 2:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster

Alignment Length:	710	Identity:	156/710 - (21%)
Similarity:	253/710 - (35%)	Gaps:	204/710 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   513 LVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTIL-----------ANASALRPGDALNLT 566
            |:|:|   |:..:.|...   .::|..|....|.|.|.|           ...:..:|.....|.
  Fly    19 LLLLT---DHNGRLTLTK---ESTTVAAAVAQPKNSTALQPYLQIQKHAVTRLTISKPHSPYYLP 77

Human   567 CVSV-------SSNPPVNLSWDKEGERLEGVAAPPRRAPF----KGSAAARSVLLQVSSRDHGQR 620
            |:.:       ..|.|:..||.:....:|.|:.  |:..|    .|     ::.|..:.:..|:
  Fly    78 CIPILTPYNHDQDNQPIYCSWYRNDVVVEQVSY--RKNDFFIYDNG-----TLRLPTNEKASGE- 134

Human   621 VTCRA---HSAELRETVSSFYRLNVLYRPEFLGEQVLV-VTAVEQGEALLPVSVSANPAPEAFNW 681
            ..|:.   .||.:.:.::..|  .||.| .|.|:|... ::|:|....:|.....:.||.. |:|
  Fly   135 YYCKIEWDESAVISDRITVEY--PVLKR-LFPGQQQAANISALENKPLVLSCPFLSVPAAR-FSW 195

Human   682 TFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEAR-----LRLD------ 735
            .|....|:.....  .||::|.|.|.::.....|.|:...||:..:...|     |:::
  Fly   196 YFGNDSLTNDNSA--LILTNGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFIWQLQVEPKDATF 258

Human   736 ------------VHYAPTIRALQDPTE-VNVGGSVDIVC--TVDANPILPGMFNWERLGEDEEDQ 785
                        |..|..:.|.|:.|. |..||||.:.|  ..|..||:     |.....:.:
  Fly   259 YPKNEAGITETAVSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPIV-----WYLQPPNNK-- 316

Human   786 SLDDMEKISRGPTGRLRIHHAKLAQ-AGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKV 849
                |.::|..... ..|.:|.:|: .|.|.||     .|...:..:::|...|::....|: :|
  Fly   317 ----MVRLSNNSVA-YSITNASIARHEGRYSCI-----TPLETQNFQVIVTTPPRIVSRLPV-EV 370

Human   850 AAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRY-TEHTYHQGGVHSSLLTIANVSAAQ 913
            ...|   .|.||.|||.|.|....||..|||.|:....|| :.:..|   |||        ..::
  Fly   371 VYIG---LSRTLTCRAEGHPEPSITWYHNGVHLNSSYTRYISGNELH---VHS--------FDSK 421

Human   914 DYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYE 978
            :..::.|.|.|..|.|....:|....:.:..:.|:.:...|||
  Fly   422 EEGIYQCVARNVAGEDSATGELRFNRQLEEVNPLQNIRCYPHS---------------------- 464

Human   979 ALGTPGFHYVDVVPPQATTF---TLTGLQPSTRYRVWLLASN----------ALGDSGLADKGTQ 1030
                  ||.:::      ||   |||.:     :.|:::.:|          .|..:......|.
  Fly   465 ------FHSINI------TFDSRTLTSM-----FVVYIVRNNPHSWTSFSPMKLNQTSYVVISTD 512

Human  1031 LPITTP-----GLHQPSGE-------PEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASCVGG 1083
            ||:..|     .:..|:.|       |:..:       .|.|...||.....||:|...|  ||.
  Fly   513 LPVYEPFALITRVLFPTTEVRTGTLVPQQMI-------LSSLRSTPVTCCTQGLMLRPIA--VGN 568

Human  1084 ---VLW-QRRLR-------------------RLAEGISEKTEAGSEE--DRVRNEYEESQ 1118
               |.| |.:|.                   :|..|..:.|....||  |:||:...|.|
  Fly   569 DTFVKWSQGQLENKKYFILQFSINHTHPHPAQLLNGSLQGTLTSVEEKADQVRHHLTEIQ 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPHS1	NP_004637.1	V-set	38..119	CDD:284989
		IG_like	38..113	CDD:214653
		C2-set_2	141..228	CDD:285423
		Ig	240..321	CDD:299845
		IG_like	254..336	CDD:214653
		Ig	345..424	CDD:299845
		Ig	445..530	CDD:299845	5/16 (31%)
		I-set	446..541	CDD:254352	6/27 (22%)
		Ig	549..632	CDD:299845	19/107 (18%)
		IG_like	558..642	CDD:214653	18/97 (19%)
		I-set	646..736	CDD:254352	23/113 (20%)
		Ig	662..736	CDD:299845	18/96 (19%)
		Ig_3	739..820	CDD:290638	23/84 (27%)
		IG_like	748..821	CDD:214653	20/76 (26%)
		Ig8_hNephrin_like	834..942	CDD:143250	31/108 (29%)
		IG_like	845..935	CDD:214653	28/90 (31%)
		fn3	942..1023	CDD:278470	14/93 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		8/22 (36%)
		Binds to NPHS2	1160..1241
plum	NP_001163744.1	IG_like	170..241	CDD:214653	18/73 (25%)
		IGc2	175..235	CDD:197706	15/62 (24%)
		IG_like	284..356	CDD:214653	21/88 (24%)
		I-set	360..443	CDD:254352	29/97 (30%)
		IGc2	378..435	CDD:197706	22/67 (33%)
		FN3	804..886	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100