| Sequence 1: | NP_004637.1 | Gene: | NPHS1 / 4868 | HGNCID: | 7908 | Length: | 1241 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001246890.1 | Gene: | nrm / 40515 | FlyBaseID: | FBgn0262509 | Length: | 2192 | Species: | Drosophila melanogaster |
| Alignment Length: | 894 | Identity: | 195/894 - (21%) |
|---|---|---|---|
| Similarity: | 339/894 - (37%) | Gaps: | 181/894 - (20%) |
- Green bases have known domain annotations that are detailed below.
|
Human 34 FWALPENLTVVEGASVELRCGVSTPGSAV-------QWAKDGLLLG------------------P 73
Human 74 DPRIPGF------PRYRLEGDPARG------EFHLHIEACDLSDDAEYECQVGRSEMGPELVSPR 126
Human 127 VILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDI------TILLSGQT-ISDIS 184
Human 185 ANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPAL----EAPIKASFTVNVLFPP----G 241
Human 242 PPVIEWPGLDEGHVRAGQSLELPCVARGGNP--LATLQWLKNGQPVSTAWGTEHTQAVARSV--L 302
Human 303 VMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIIL---GSASQTENKNVTLSCVSK 364
Human 365 SSRPRVL--LRWWLG---WRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEA- 423
Human 424 FTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVC-LAIGGNPEPS-LMWYKDSRTVT 486
Human 487 ESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQ-LSASTQLAVQFPPT 546
Human 547 NVTIL-ANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEG-----------VAAPPRRAPF 599
Human 600 KGSAAARSVL-------------LQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPE--FL 649
Human 650 GEQVLVVTAVEQGEALLPVSV----SANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWN-- 708
Human 709 VTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMF 773
Human 774 NWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGV 822 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| NPHS1 | NP_004637.1 | V-set | 38..119 | CDD:462230 | 25/117 (21%) |
| C2-set_2 | 141..228 | CDD:400489 | 22/97 (23%) | ||
| Ig strand B | 156..160 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 170..174 | CDD:409353 | 1/9 (11%) | ||
| Ig strand E | 200..204 | CDD:409353 | 0/3 (0%) | ||
| Ig strand F | 214..219 | CDD:409353 | 1/4 (25%) | ||
| Ig strand G | 229..232 | CDD:409353 | 0/2 (0%) | ||
| Ig | 237..336 | CDD:472250 | 25/106 (24%) | ||
| Ig strand B | 261..265 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 275..279 | CDD:409353 | 0/3 (0%) | ||
| Ig strand E | 300..304 | CDD:409353 | 1/5 (20%) | ||
| Ig strand F | 314..319 | CDD:409353 | 2/4 (50%) | ||
| Ig strand G | 332..335 | CDD:409353 | 1/2 (50%) | ||
| Ig | 345..424 | CDD:472250 | 24/87 (28%) | ||
| Ig strand B | 357..361 | CDD:409353 | 3/3 (100%) | ||
| Ig strand C | 371..375 | CDD:409353 | 2/5 (40%) | ||
| Ig strand E | 400..404 | CDD:409353 | 2/3 (67%) | ||
| Ig strand F | 414..419 | CDD:409353 | 1/4 (25%) | ||
| Ig strand G | 430..433 | CDD:409353 | 1/2 (50%) | ||
| Ig | 446..541 | CDD:472250 | 18/101 (18%) | ||
| Ig strand B | 461..465 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 475..479 | CDD:409353 | 0/4 (0%) | ||
| Ig strand E | 510..515 | CDD:409353 | 0/4 (0%) | ||
| Ig strand F | 525..530 | CDD:409353 | 1/4 (25%) | ||
| Ig | 549..632 | CDD:472250 | 18/107 (17%) | ||
| Ig strand B | 563..567 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 577..581 | CDD:409353 | 1/3 (33%) | ||
| Ig strand E | 606..610 | CDD:409353 | 3/16 (19%) | ||
| Ig strand F | 620..625 | CDD:409353 | 1/4 (25%) | ||
| Ig strand G | 635..638 | CDD:409353 | 1/2 (50%) | ||
| Ig | 646..736 | CDD:472250 | 23/97 (24%) | ||
| Ig strand B | 664..668 | CDD:409353 | 0/3 (0%) | ||
| Ig strand C | 678..682 | CDD:409353 | 0/3 (0%) | ||
| Ig strand E | 702..706 | CDD:409353 | 1/3 (33%) | ||
| Ig strand F | 716..721 | CDD:409353 | 1/4 (25%) | ||
| Ig strand G | 729..732 | CDD:409353 | 1/2 (50%) | ||
| Ig_3 | 740..820 | CDD:464046 | 19/79 (24%) | ||
| IgC1_hNephrin_like | 834..942 | CDD:143250 | |||
| putative Ig strand A | 839..844 | CDD:143250 | |||
| putative Ig strand B | 859..866 | CDD:143250 | |||
| putative Ig strand C | 870..876 | CDD:143250 | |||
| putative Ig strand C' | 879..881 | CDD:143250 | |||
| putative Ig strand D | 888..891 | CDD:143250 | |||
| putative Ig strand E | 898..906 | CDD:143250 | |||
| putative Ig strand F | 917..924 | CDD:143250 | |||
| putative Ig strand G | 939..942 | CDD:143250 | |||
| FN3 | 941..1022 | CDD:238020 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1025..1057 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1099..1137 | ||||
| Binds to NPHS2 | 1160..1241 | ||||
| nrm | NP_001246890.1 | V-set | 44..152 | CDD:462230 | 6/21 (29%) |
| Ig strand B | 183..187 | CDD:409353 | 0/3 (0%) | ||
| Ig | <185..248 | CDD:472250 | 14/65 (22%) | ||
| Ig strand C | 197..201 | CDD:409353 | 0/3 (0%) | ||
| Ig strand E | 225..229 | CDD:409353 | 1/3 (33%) | ||
| Ig strand F | 239..244 | CDD:409353 | 3/6 (50%) | ||
| Ig strand G | 253..256 | CDD:409353 | 0/2 (0%) | ||
| Ig | 277..354 | CDD:472250 | 19/77 (25%) | ||
| Ig strand B | 283..287 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 297..301 | CDD:409353 | 0/3 (0%) | ||
| Ig strand E | 333..337 | CDD:409353 | 0/3 (0%) | ||
| Ig strand F | 347..352 | CDD:409353 | 1/4 (25%) | ||
| Ig_3 | 376..456 | CDD:464046 | 19/89 (21%) | ||
| Ig | 676..779 | CDD:472250 | 18/110 (16%) | ||
| Ig strand B | 689..693 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 702..706 | CDD:409353 | 1/3 (33%) | ||
| Ig strand E | 734..741 | CDD:409353 | 1/9 (11%) | ||
| Ig strand F | 762..767 | CDD:409353 | 1/8 (13%) | ||
| Ig | <811..869 | CDD:472250 | 16/69 (23%) | ||
| Ig strand C | 820..824 | CDD:143205 | 0/3 (0%) | ||
| Ig strand F | 849..854 | CDD:143205 | 1/4 (25%) | ||
| Ig strand G | 862..865 | CDD:143205 | 1/2 (50%) | ||
| PTZ00112 | 1747..>1940 | CDD:240274 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||