DRSC/TRiP Functional Genomics Resources

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Protein Alignment NPHS1 and side-V

DIOPT Version :10

Sequence 1:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens
Sequence 2:NP_611765.2 Gene:side-V / 37679 FlyBaseID:FBgn0085400 Length:1174 Species:Drosophila melanogaster


Alignment Length:1181 Identity:247/1181 - (20%)
Similarity:406/1181 - (34%) Gaps:343/1181 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   201 TARVTPRSSDNRQLLVCEASS-------PAL--EAPIKASFTV---NVLFP----PGPPVIEWPG 249
            :|.|.||......|::..|.|       ||.  |.|:....|.   .|..|    ||..:::   
  Fly     5 SAAVFPRQPVAFVLVLATALSLVQGEQHPATADEGPLSEILTAVGSEVALPCDLVPGTGIVD--- 66

Human   250 LDEGHVRAGQSLELPCVARGGN--PLATLQWLKNGQPVSTA--WGTE---------HTQAVARSV 301
                      .::|....|.||  |:.|..  ..|:|::..  |..|         |......::
  Fly    67 ----------KVQLVIWYRQGNVKPIYTFD--ARGRPLNLGIPWADESVFNKKAHFHHDTDPPAL 119

Human   302 LVMTVRPEDHGA-QLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGS-----ASQT-----ENK 355
            .:..::..|.|. :...:.|.|   .|:...|.:.|..||:|:.||..     ..||     |..
  Fly   120 RIKNIQTSDAGLYKCRVDFHKS---PTRNWRINVTVLVPPTALTILDHHGAEIRDQTAGPYLEGD 181

Human   356 NVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAF 420
            ::.|:|:|....|...:.||.....:....:.:.||.....:.:.|:    :|:|.....||:| 
  Fly   182 SIDLTCLSSGGVPPPRVSWWREHALIDDSFQVLPDGSVRNVLRLKNI----QRKDLLTMYTCQA- 241

Human   421 SEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTV 485
            |.........|.:||::..|...|.::|  ....:.||||..:.|.|||..|.|.::|.|..:.|
  Fly   242 SNGHVVPALTKKVILDMNLPPLSLLLQG--LNHAVIAGTRSHVTCTAIGARPPPEIIWSKAGQIV 304

Human   486 TESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNV-T 549
                      |....|....|:|...||:|:..|.||:.:..|.....:..|...:....|.| |
  Fly   305 ----------RGATSSTSSDGNTTISELMLIPVPEDNERQVVCSISLNAGITSQQLHEGHTTVMT 359

Human   550 ILANASA---LRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQ 611
            .|.|...   |:....||:|     ..|.|||:          :.||                  
  Fly   360 TLGNGHTGLYLKDSRVLNVT-----HAPIVNLN----------LGAP------------------ 391

Human   612 VSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAP 676
                                            ..|:.|         ::..:..|...|.||||.
  Fly   392 --------------------------------LDPDNL---------LKGTDVYLECDVKANPAI 415

Human   677 EAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEA-RLRLDVHYAP 740
            ....|.....:|..:.|   .|:|:..|.|..::::..|.|.....|.:|:..: .:.|||.|.|
  Fly   416 TRVEWYHSDKQLHSSRG---IIISNQTLVLQGISKSSHGQYFCRASNLQGSVSSNEVYLDVKYPP 477

Human   741 TIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNW------ERL----------------GEDEE 783
            ..::........:..:::|.|.|||||:....:.|      |.|                |.|:.
  Fly   478 VCKSESTIIRAALKQTINITCEVDANPVDNLNYKWHFNNSLESLIELPQLGQGAPVMLASGSDQS 542

Human   784 DQSLDDMEKISRGPTGRLRIH--HAKLAQA----------GAYQCIVDNGVAPPARRLLRLVV-- 834
            ........|.|.|...|| :|  |.::|..          |.::...|....|..:.:...:|  
  Fly   543 GYYQRSKRKHSHGMQQRL-LHGRHGRMAAVRFEDEDEDGYGEFEEYGDEVGQPFTQMVYSNMVHK 606

Human   835 ------------RFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDP 887
                        :.:||.:...  .::|:.|.|..|.|               ...||.|:.:..
  Fly   607 NHVESSKQQQRKQLSPQQQQQQ--QQMASGGSSGDSHT---------------PSGGVILERKRL 654

Human   888 RYTEHTYHQGGVHSSLLTIA----------NVSAAQDYALFTCTATNALGSDQT---NIQLVSIS 939
            ......:|:|||.:...|.|          :|.:.:.:...:|.|::.:|....   :||...: 
  Fly   655 VALHKQHHRGGVATPPTTTAAPPLNNVYSYHVESYESFGAISCVASSPMGHSAPCWYHIQPADL- 718

Human   940 RPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIR-YEALG-----TPGFHYVDVVPPQATTF 998
             |:|.......:.|.:|:.::..||:|||:||.|..: |:.|.     ...:.|        :.|
  Fly   719 -PEPVKNCTAYNATANSLQIQCIPGYDGGIPQHFHAQIYDELNRQILYNASYKY--------SEF 774

Human   999 TLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGLPLL 1063
            |:..|...:.:.:.:.|.||.|.|.:|.:.....::.|.|...|            |....:.|.
  Fly   775 TVKRLPSDSVFVIRITAVNAQGASKVAYRLRGRTLSAPLLRTAS------------STAVLVQLT 827

Human  1064 PVLFALGGLL--LLSNASCVGGVLWQRRLRRLAEGISEKTEAGSEEDRVRNEYEESQWTGERDTQ 1126
            |:|.||.|::  |:..|.||..|:..|                            |:..|.|...
  Fly   828 PLLGALVGVIATLILVAICVVIVIKFR----------------------------SKRGGRRHGS 864

Human  1127 SSTVSTTE-----AEPYYR------SLRDFSPQLPPT---------QEEVSYSRGFTGEDEDMAF 1171
            .:..:|||     |||..|      ||.|.:|.:.|.         |||.::.| ...|.:.:.:
  Fly   865 GADATTTEADKGSAEPLSRNMGSHSSLEDKNPDVVPQEANSEDEFHQEEKAFDR-LNMESQRILY 928

Human  1172 P-------------------GHLYDEVERTYPPSGAWGPLYDEVQMGP------WDLHWPEDTYQ 1211
            .                   |..|.|:..|..|:.:   ||:..|..|      :....|..:.:
  Fly   929 TPPTRINTASPPPPSLSPTFGKQYGELSLTTNPAFS---LYNTPQRAPAVQRPVYTAPPPLLSTR 990

Human  1212 DPRGIYDQVAG 1222
            .|..||.::.|
  Fly   991 TPPNIYTRIPG 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPHS1NP_004637.1 V-set 38..119 CDD:462230
C2-set_2 141..228 CDD:400489 10/35 (29%)
Ig strand B 156..160 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 200..204 CDD:409353 1/2 (50%)
Ig strand F 214..219 CDD:409353 1/4 (25%)
Ig strand G 229..232 CDD:409353 0/2 (0%)
Ig 237..336 CDD:472250 20/116 (17%)
Ig strand B 261..265 CDD:409353 1/3 (33%)
Ig strand C 275..279 CDD:409353 1/3 (33%)
Ig strand E 300..304 CDD:409353 0/3 (0%)
Ig strand F 314..319 CDD:409353 0/4 (0%)
Ig strand G 332..335 CDD:409353 1/2 (50%)
Ig 345..424 CDD:472250 20/88 (23%)
Ig strand B 357..361 CDD:409353 1/3 (33%)
Ig strand C 371..375 CDD:409353 0/3 (0%)
Ig strand E 400..404 CDD:409353 1/3 (33%)
Ig strand F 414..419 CDD:409353 2/4 (50%)
Ig strand G 430..433 CDD:409353 1/2 (50%)
Ig 446..541 CDD:472250 26/94 (28%)
Ig strand B 461..465 CDD:409353 0/3 (0%)
Ig strand C 475..479 CDD:409353 0/3 (0%)
Ig strand E 510..515 CDD:409353 2/4 (50%)
Ig strand F 525..530 CDD:409353 1/4 (25%)
Ig 549..632 CDD:472250 13/85 (15%)
Ig strand B 563..567 CDD:409353 2/3 (67%)
Ig strand C 577..581 CDD:409353 2/3 (67%)
Ig strand E 606..610 CDD:409353 0/3 (0%)
Ig strand F 620..625 CDD:409353 0/4 (0%)
Ig strand G 635..638 CDD:409353 0/2 (0%)
Ig 646..736 CDD:472250 20/90 (22%)
Ig strand B 664..668 CDD:409353 1/3 (33%)
Ig strand C 678..682 CDD:409353 0/3 (0%)
Ig strand E 702..706 CDD:409353 1/3 (33%)
Ig strand F 716..721 CDD:409353 1/4 (25%)
Ig strand G 729..732 CDD:409353 0/3 (0%)
Ig_3 740..820 CDD:464046 22/113 (19%)
IgC1_hNephrin_like 834..942 CDD:143250 23/134 (17%)
putative Ig strand A 839..844 CDD:143250 1/4 (25%)
putative Ig strand B 859..866 CDD:143250 1/6 (17%)
putative Ig strand C 870..876 CDD:143250 0/5 (0%)
putative Ig strand C' 879..881 CDD:143250 1/1 (100%)
putative Ig strand D 888..891 CDD:143250 0/2 (0%)
putative Ig strand E 898..906 CDD:143250 2/7 (29%)
putative Ig strand F 917..924 CDD:143250 2/6 (33%)
putative Ig strand G 939..942 CDD:143250 0/2 (0%)
FN3 941..1022 CDD:238020 22/86 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 5/31 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137 7/42 (17%)
Binds to NPHS2 1160..1241 16/88 (18%)
side-VNP_611765.2 V-set 42..153 CDD:462230 22/128 (17%)
Ig_3 178..243 CDD:464046 15/69 (22%)
Ig 274..359 CDD:472250 27/94 (29%)
Ig strand B 280..284 CDD:409353 0/3 (0%)
Ig strand C 294..298 CDD:409353 0/3 (0%)
Ig strand E 320..324 CDD:409353 2/3 (67%)
Ig strand F 334..345 CDD:409353 1/10 (10%)
Ig strand G 355..358 CDD:409353 1/2 (50%)
Ig 400..466 CDD:472250 17/68 (25%)
Ig strand B 403..407 CDD:409353 1/3 (33%)
Ig strand C 416..421 CDD:409353 0/4 (0%)
Ig strand E 438..442 CDD:409353 1/3 (33%)
Ig strand F 452..457 CDD:409353 1/4 (25%)
Ig strand G 465..468 CDD:409353 0/2 (0%)
FN3 719..798 CDD:214495 22/86 (26%)
Blue background indicates that the domain is not in the aligned region.

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