DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPHS1 and Fas3

DIOPT Version :9

Sequence 1:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens
Sequence 2:	NP_001097174.1	Gene:	Fas3 / 35097	FlyBaseID:	FBgn0000636	Length:	577	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	78/368 - (21%)
Similarity:	133/368 - (36%)	Gaps:	90/368 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESR--LPQESRRVHLGSVEKS---GSTF 509
            |....|..|.|..|:|              :..|::...|  :|.|.:.::| |.|.|   |.|:
  Fly    26 PNTALLNEGDRTELLC--------------RYGRSINYCRIEIPGEQKVLNL-SPEWSKTPGFTY 75

Human   510 ------------SRELVLVTGPSDNQAKFTCKAG----QLSASTQLAVQFPPTN--VTILANASA 556
                        |.|.|    .:.|..:..|..|    :||.:..|.|...|..  :.:|:..:.
  Fly    76 FGAGLTAGQCGVSIERV----KASNNGQVKCSLGVEGEELSGTIDLVVALRPQQPIIELLSRPNR 136

Human   557 ---LRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKG----------SAAARSV 608
               ...|......|......||.|:||     .::.:.|..|..|.:.          |.:.:.:
  Fly   137 EGYFNEGTEFRARCSVRDGRPPANISW-----YIDNMPANKRTTPLEVMSSTNDNVELSTSVQEI 196

Human   609 LLQVSSRDHGQRVTCRAHSAELRETV---SSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSV 670
            ...:|..|..:::.||:|....||:|   .:.|.:||.|.|....:..:....:|. .|::.:::
  Fly   197 QWHLSPEDSNRKLVCRSHHQTDRESVPPQEAAYIINVRYAPVHQPDAAVYGLYLEH-TAIVNITI 260

Human   671 SANPAPEAFNWTFRG--------------YRLSPAGGPRHRI-LSSGALHLWNVTRADDGLYQLH 720
            .|:|.|: ..||..|              |.....|...:.: |:...|.|.:.|:    :|.|.
  Fly   261 RASPQPK-IEWTIDGAIVGQGRTDGRYSAYEPQYLGNDEYNVTLAIAGLTLEDTTK----IYNLR 320

Human   721 CQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTV 763
            ..|..|..:.::|:.....|...:|      :|...|.||..|
  Fly   321 ASNELGLTDYQVRISSSSKPPSSSL------DVAAIVGIVVAV 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPHS1	NP_004637.1	V-set	38..119	CDD:284989
		IG_like	38..113	CDD:214653
		C2-set_2	141..228	CDD:285423
		Ig	240..321	CDD:299845
		IG_like	254..336	CDD:214653
		Ig	345..424	CDD:299845
		Ig	445..530	CDD:299845	21/96 (22%)
		I-set	446..541	CDD:254352	25/111 (23%)
		Ig	549..632	CDD:299845	17/95 (18%)
		IG_like	558..642	CDD:214653	20/96 (21%)
		I-set	646..736	CDD:254352	20/104 (19%)
		Ig	662..736	CDD:299845	18/88 (20%)
		Ig_3	739..820	CDD:290638	7/25 (28%)
		IG_like	748..821	CDD:214653	5/16 (31%)
		Ig8_hNephrin_like	834..942	CDD:143250
		IG_like	845..935	CDD:214653
		fn3	942..1023	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137
		Binds to NPHS2	1160..1241
Fas3	NP_001097174.1	C2-set_2	141..221	CDD:285423	17/84 (20%)
Fas3	NP_001097174.1	Ig_TrkABC_d4	235..>333	CDD:143173	20/103 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010