DRSC/TRiP Functional Genomics Resources

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Protein Alignment NPHS1 and fred

DIOPT Version :10

Sequence 1:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens
Sequence 2:NP_608812.3 Gene:fred / 33613 FlyBaseID:FBgn0051774 Length:1447 Species:Drosophila melanogaster


Alignment Length:1106 Identity:219/1106 - (19%)
Similarity:371/1106 - (33%) Gaps:340/1106 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    11 LLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVS----TPGSAVQWAK----- 66
            ||::|.|     .|:|      |..:..::|...||..:.|:|..:    :......||:     
  Fly     6 LLIIGQL-----WLSI------GLISGDDSLDTREGVDLVLKCRFTEHYDSTDFTFYWARWTCCP 59

Human    67 ---DGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLS-DDAEYECQVGRSEMGPELVSPRV 127
               :.:.:| |.::..  .|||:..|:||.:.|.|:....: |:..:||::.....|.::.....
  Fly    60 TLFENVAIG-DVQLNS--NYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGADVHQEFY 121

Human   128 ILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQ 192
            .|::|..|...::||  |.:......:...:.|.|....|.|.||....|.|: .:.:...:|..
  Fly   122 NLTVLTAPHPPMVTP--GNLAVATEEKPLELTCSSIGGSPDPMITWYREGSTV-PLQSYALKGGS 183

Human   193 QKLFTVEATARVTPRSSDNRQLLVCEASSPALEA--PIKASFTVNVLFPP----GP--PVIEWPG 249
            :..:| .||.::.||.:|:.....|...:.|:..  .::.|.|:||.:.|    ||  |:    .
  Fly   184 KNHYT-NATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPL----K 243

Human   250 LDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQ 314
            ::..||     .:|.|.......::.::|.:|||.|| |..|.....|.|          .|..:
  Fly   244 VERDHV-----AKLDCRVDAKPMVSNVRWSRNGQYVS-ATPTHTIYRVNR----------HHAGK 292

Human   315 LSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWR 379
            .:|.|.|.:.. |.|..|.|.|.:||...|...:....|.:.|.:.|...::...:.:.|     
  Fly   293 YTCSADNGLGK-TGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEW----- 351

Human   380 QLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTC------EAFSEAFTKETFKKSLILNVK 438
                ::|...|..:.|.:    ||..:.|.::.....|      :.||....:.....::.|.|:
  Fly   352 ----LKEGAPDFRYTGEL----LTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVR 408

Human   439 YPAQKLWIEGPPEGQKLRAGTRVRLVCLA-IGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSV 502
            :...:.:|  .|....:..|..|.|.|.| ..|.|.|...|::|                     
  Fly   409 HRPGQAYI--TPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRD--------------------- 450

Human   503 EKSGSTFSRELVLVTGPS--------DNQAKFTCKA------GQLSASTQLAVQFPPTNVTILAN 553
             ..|...:.:.:|..||.        .::.|:.|.|      |:: |:..|.|..||..:..|..
  Fly   451 -MDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVNELGIGKI-ATIILEVHQPPQFLAKLQQ 513

Human   554 ASALRPGDA-LNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDH 617
            ....|.||. ..:|| |....|...:.|.|:|..:     .|.|..|.         ::.:..|.
  Fly   514 HMTRRVGDVDYAVTC-SAKGKPTPQIRWIKDGTEI-----LPTRKMFD---------IRTTPTDA 563

Human   618 GQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWT 682
            |..|.          .|.|..|.....||              .|..|||               
  Fly   564 GGGVV----------AVQSILRFRGKARP--------------NGNQLLP--------------- 589

Human   683 FRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQD 747
                                         .|.|||....:|...:|.:.:.|.:.:.|.:....:
  Fly   590 -----------------------------NDRGLYTCLYENDVNSANSSMHLRIEHEPIVIHQYN 625

Human   748 PTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAG 812
            ....::..|.::||.|.|.|  ...|.|                                  |.|
  Fly   626 KVAYDLRESAEVVCRVQAYP--KPEFQW----------------------------------QYG 654

Human   813 AYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTK 877
                                        .:|:|||..:                           
  Fly   655 ----------------------------NNPSPLTMSS--------------------------- 664

Human   878 NGVPLDLQDPRYTEHT-YHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP 941
                    |..|...| .....|::|:|.||::..: ||..:.|.|.|.|.|.:..|:|.....|
  Fly   665 --------DGHYEISTRMENNDVYTSILRIAHLQHS-DYGEYICRAVNPLDSIRAPIRLQPKGSP 720

Human   942 DPPSGLKVVSLTPHSVGLEWKPGFDGG-LPQRFCIRYEALGTP---------GFHYVDVVPPQAT 996
            :.|:.||::.:..:...|.|.|||:|| :..::.:.|..:.||         |..|:......::
  Fly   721 EKPTNLKILEVGHNYAVLNWTPGFNGGFMSTKYLVSYRRVATPREQTLSDCSGNGYIPSYQISSS 785

Human   997 TFT-----------------LTGLQPSTRYRVWLLASNALGDSGLAD------KGTQLPITTPGL 1038
            :..                 |..|.....|...:.|.|:.|.||.::      |.:::|   |.|
  Fly   786 SSNSNHEWIEFNCFKENPCKLAPLDQHQSYMFKVYALNSKGTSGYSNEILATTKVSKIP---PPL 847

Human  1039 H 1039
            |
  Fly   848 H 848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPHS1NP_004637.1 V-set 38..119 CDD:462230 20/93 (22%)
C2-set_2 141..228 CDD:400489 20/88 (23%)
Ig strand B 156..160 CDD:409353 0/3 (0%)
Ig strand C 170..174 CDD:409353 2/3 (67%)
Ig strand E 200..204 CDD:409353 2/3 (67%)
Ig strand F 214..219 CDD:409353 1/4 (25%)
Ig strand G 229..232 CDD:409353 0/2 (0%)
Ig 237..336 CDD:472250 26/104 (25%)
Ig strand B 261..265 CDD:409353 1/3 (33%)
Ig strand C 275..279 CDD:409353 0/3 (0%)
Ig strand E 300..304 CDD:409353 0/3 (0%)
Ig strand F 314..319 CDD:409353 1/4 (25%)
Ig strand G 332..335 CDD:409353 1/2 (50%)
Ig 345..424 CDD:472250 13/84 (15%)
Ig strand B 357..361 CDD:409353 1/3 (33%)
Ig strand C 371..375 CDD:409353 0/3 (0%)
Ig strand E 400..404 CDD:409353 1/3 (33%)
Ig strand F 414..419 CDD:409353 1/10 (10%)
Ig strand G 430..433 CDD:409353 0/2 (0%)
Ig 446..541 CDD:472250 22/109 (20%)
Ig strand B 461..465 CDD:409353 2/3 (67%)
Ig strand C 475..479 CDD:409353 0/3 (0%)
Ig strand E 510..515 CDD:409353 0/4 (0%)
Ig strand F 525..530 CDD:409353 2/4 (50%)
Ig 549..632 CDD:472250 17/83 (20%)
Ig strand B 563..567 CDD:409353 0/3 (0%)
Ig strand C 577..581 CDD:409353 0/3 (0%)
Ig strand E 606..610 CDD:409353 0/3 (0%)
Ig strand F 620..625 CDD:409353 1/4 (25%)
Ig strand G 635..638 CDD:409353 1/2 (50%)
Ig 646..736 CDD:472250 12/89 (13%)
Ig strand B 664..668 CDD:409353 2/3 (67%)
Ig strand C 678..682 CDD:409353 0/3 (0%)
Ig strand E 702..706 CDD:409353 0/3 (0%)
Ig strand F 716..721 CDD:409353 2/4 (50%)
Ig strand G 729..732 CDD:409353 0/2 (0%)
Ig_3 740..820 CDD:464046 11/79 (14%)
IgC1_hNephrin_like 834..942 CDD:143250 21/108 (19%)
putative Ig strand A 839..844 CDD:143250 0/4 (0%)
putative Ig strand B 859..866 CDD:143250 0/6 (0%)
putative Ig strand C 870..876 CDD:143250 0/5 (0%)
putative Ig strand C' 879..881 CDD:143250 0/1 (0%)
putative Ig strand D 888..891 CDD:143250 1/2 (50%)
putative Ig strand E 898..906 CDD:143250 3/7 (43%)
putative Ig strand F 917..924 CDD:143250 2/6 (33%)
putative Ig strand G 939..942 CDD:143250 0/2 (0%)
FN3 941..1022 CDD:238020 22/107 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137
Binds to NPHS2 1160..1241
fredNP_608812.3 Ig 132..228 CDD:472250 22/99 (22%)
Ig strand B 148..152 CDD:409353 0/3 (0%)
Ig strand C 162..166 CDD:409353 2/3 (67%)
Ig strand E 190..194 CDD:409353 2/3 (67%)
Ig strand F 204..209 CDD:409353 1/4 (25%)
Ig strand G 221..224 CDD:409353 0/2 (0%)
Ig 238..313 CDD:472250 24/95 (25%)
Ig strand B 250..254 CDD:409353 1/3 (33%)
Ig strand C 264..268 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 1/3 (33%)
Ig strand F 292..297 CDD:409353 1/4 (25%)
Ig strand G 306..309 CDD:409353 1/2 (50%)
Ig_3 316..385 CDD:464046 14/81 (17%)
Ig_2 416..501 CDD:464026 22/109 (20%)
Ig 523..614 CDD:472250 29/173 (17%)
Ig strand B 524..528 CDD:409568 0/3 (0%)
Ig strand C 537..541 CDD:409568 0/3 (0%)
Ig strand E 566..570 CDD:409568 1/13 (8%)
Ig strand F 594..599 CDD:409568 2/4 (50%)
Ig strand G 607..610 CDD:409568 0/2 (0%)
Ig_3 618..703 CDD:464046 27/184 (15%)
FN3 720..838 CDD:238020 24/117 (21%)
Blue background indicates that the domain is not in the aligned region.

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