Sequence 1: | NP_004637.1 | Gene: | NPHS1 / 4868 | HGNCID: | 7908 | Length: | 1241 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001014485.3 | Gene: | side-II / 3346206 | FlyBaseID: | FBgn0259213 | Length: | 1064 | Species: | Drosophila melanogaster |
Alignment Length: | 876 | Identity: | 186/876 - (21%) |
---|---|---|---|
Similarity: | 307/876 - (35%) | Gaps: | 219/876 - (25%) |
- Green bases have known domain annotations that are detailed below.
Human 353 ENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPM-------EETVMDGLHGG-----------HISM 399
Human 400 SNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKL----W---IEGPPEGQKLRA 457
Human 458 GTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPS-- 520
Human 521 --DNQAKFTCKA--GQLSASTQ----LAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVN 577
Human 578 LSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVS----SRDHGQRVTCRAHSAELRET-VSSF 637
Human 638 YRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSG 702
Human 703 ALHLWNVTRADDGLYQLHCQ-NSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDAN 766
Human 767 PILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLR 831
Human 832 LVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKN--GVPLDLQDPRYTEHTY 894
Human 895 HQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQ--TNIQLVSISRPDPPSGLKVVSLTPHSV 957
Human 958 GLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDS 1022
Human 1023 GLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSG--------LPLLPVLFALGGLLLL---- 1075
Human 1076 -SNASCVGGVLWQRRLRRLAEGISEKTEAG---SEEDRVR-NEYEESQWTGERDTQSSTVSTTEA 1135
Human 1136 EPYYRSLRDFSPQLPPTQEEVSYSRGFTGED 1166 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
NPHS1 | NP_004637.1 | V-set | 38..119 | CDD:284989 | |
IG_like | 38..113 | CDD:214653 | |||
C2-set_2 | 141..228 | CDD:285423 | |||
Ig | 240..321 | CDD:299845 | |||
IG_like | 254..336 | CDD:214653 | |||
Ig | 345..424 | CDD:299845 | 16/88 (18%) | ||
Ig | 445..530 | CDD:299845 | 22/91 (24%) | ||
I-set | 446..541 | CDD:254352 | 25/104 (24%) | ||
Ig | 549..632 | CDD:299845 | 21/86 (24%) | ||
IG_like | 558..642 | CDD:214653 | 19/88 (22%) | ||
I-set | 646..736 | CDD:254352 | 10/90 (11%) | ||
Ig | 662..736 | CDD:299845 | 9/74 (12%) | ||
Ig_3 | 739..820 | CDD:290638 | 14/80 (18%) | ||
IG_like | 748..821 | CDD:214653 | 13/72 (18%) | ||
Ig8_hNephrin_like | 834..942 | CDD:143250 | 28/111 (25%) | ||
IG_like | 845..935 | CDD:214653 | 23/93 (25%) | ||
fn3 | 942..1023 | CDD:278470 | 20/80 (25%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1025..1057 | 5/31 (16%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1099..1137 | 8/41 (20%) | |||
Binds to NPHS2 | 1160..1241 | 2/7 (29%) | |||
side-II | NP_001014485.3 | IG_like | 55..160 | CDD:214653 | 18/99 (18%) |
Ig | 57..160 | CDD:299845 | 18/99 (18%) | ||
Ig | 188..251 | CDD:299845 | 19/77 (25%) | ||
Ig | 289..363 | CDD:299845 | 19/82 (23%) | ||
IG_like | 289..351 | CDD:214653 | 18/70 (26%) | ||
Ig_2 | 376..460 | CDD:290606 | 26/170 (15%) | ||
IG_like | 383..454 | CDD:214653 | 22/118 (19%) | ||
Ig | 470..548 | CDD:299845 | 21/85 (25%) | ||
IG_like | 481..557 | CDD:214653 | 21/83 (25%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG3515 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |