DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPHS1 and kirre

DIOPT Version :9

Sequence 1:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	685	Identity:	151/685 - (22%)
Similarity:	235/685 - (34%)	Gaps:	217/685 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    22 AQLAIPASVPRG-------FWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPG 79
            |..|...|.|:|       |...|::.|.|.|:.|.|.|.|.....|:||.||...||....:.|
  Fly    65 ASSANDESKPKGGDNGGQHFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSG 129

Human    80 FPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVI-LSILVPPKLLLLTPE 143
            |.||.:.|....|:|.|.|....|.|||:|:||||....|.:.:..|.. |::||||:
  Fly   130 FERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPE------- 187

Human   144 AGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRS 208
                                    ||.||                :|..  |.|.|
  Fly   188 ------------------------APKIT----------------QGDY--LVTTE--------- 201

Human   209 SDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPL 273
                                                             .:.:||.||::||.|.
  Fly   202 -------------------------------------------------DREIELECVSQGGKPA 217

Human   274 ATLQWLKNGQPVSTAWGTEHT--------QAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEH 330
            |.:.|:.....|.|. |.|:.        :..|||:|.:..:.|.|....:|:|.|:.....:..
  Fly   218 AEITWIDGLGNVLTK-GIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTYRSA 281

Human   331 GITLQVTFPPSAII-ILGSA----SQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMD 390
            .:.|:|.:.|..|: ::|.|    ...|...|.|||.:.::...:..||::.            |
  Fly   282 KLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFIN------------D 334

Human   391 GLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGP-----P 450
            .|..|..:...:.....|:.:...:.||..:.....|..||   |::.:        ||     |
  Fly   335 ELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKK---LDISF--------GPVFRQRP 388

Human   451 EGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSR-----TVTESRLPQESRRVHLGSVEKSGSTFS 510
            ...:...|..|.:.| .:.|||||.:.|..::.     ...|.:|...|        |.:|..|.
  Fly   389 VSVEADLGATVSMRC-DVAGNPEPEIEWISENSDQVVGVAAELKLKVSS--------ETAGRYFC 444

Human   511 RELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPP 575
            :  .:|.|..:..|:.|....:....|...|||...             |..:.:.|::.|....
  Fly   445 K--AVVNGFPEIGAEATLYVKRAPIITSHKVQFGGV-------------GGRVKIDCLAFSIPKA 494

Human   576 VNLSWDKEGERLEGVAAPPRRAPF------KGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETV 634
            .::.|..||:.:...:|.|....|      :|..||  ::::.|...|..:..|         ||
  Fly   495 EHILWSFEGKIINMSSADPDIYIFEEHHLPEGVRAA--LIIRDSKATHFGKYNC---------TV 548

Human   635 SSFYRLNVLYRPEFLGEQVLVVTAV-EQGEALLPV 668
            .:.|           |...||:|.: |.|.  :||
  Fly   549 MNSY-----------GGDSLVITLLREPGN--IPV 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPHS1	NP_004637.1	V-set	38..119	CDD:284989	33/80 (41%)
		IG_like	38..113	CDD:214653	30/74 (41%)
		C2-set_2	141..228	CDD:285423	8/86 (9%)
		Ig	240..321	CDD:299845	21/88 (24%)
		IG_like	254..336	CDD:214653	23/89 (26%)
		Ig	345..424	CDD:299845	15/82 (18%)
		Ig	445..530	CDD:299845	22/94 (23%)
		I-set	446..541	CDD:254352	23/104 (22%)
		Ig	549..632	CDD:299845	15/88 (17%)
		IG_like	558..642	CDD:214653	18/89 (20%)
		I-set	646..736	CDD:254352	8/24 (33%)
		Ig	662..736	CDD:299845	3/7 (43%)
		Ig_3	739..820	CDD:290638
		IG_like	748..821	CDD:214653
		Ig8_hNephrin_like	834..942	CDD:143250
		IG_like	845..935	CDD:214653
		fn3	942..1023	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137
		Binds to NPHS2	1160..1241
kirre	NP_001245505.1	Ig	87..183	CDD:299845	36/95 (38%)
		IG_like	88..182	CDD:214653	36/93 (39%)
		C2-set_2	189..279	CDD:285423	29/166 (17%)
		Ig_2	307..379	CDD:290606	17/86 (20%)
		I-set	382..462	CDD:254352	21/90 (23%)
		IGc2	396..446	CDD:197706	15/60 (25%)
		Ig	466..561	CDD:299845	25/129 (19%)
		IG_like	478..561	CDD:214653	21/117 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920