DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPHS1 and rst

DIOPT Version :9

Sequence 1:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	840	Identity:	199/840 - (23%)
Similarity:	290/840 - (34%)	Gaps:	231/840 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   439 YPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESR-LPQESRRVHLGSV 502
            |..|:..:|  |:.|....|.||.|.|..|  |.:.:|.|.||...:..|| |....|...:||.
  Fly    25 YQNQRFAME--PQDQTAVVGARVTLPCRVI--NKQGTLQWTKDDFGLGTSRDLSGFERYAMVGSD 85

Human   503 EKSGSTFSRELVLVTGPSDNQAKFTCKA-----GQ---LSASTQLAVQFPPTNVTILANASALRP 559
            |:...:.....|::    |:.|::.|:.     ||   .|....|.|..||       .|..:..
  Fly    86 EEGDYSLDIYPVML----DDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPP-------EAPKITQ 139

Human   560 GDALNLT--------CVSVSSNPPVNLSW-DKEG----ERLEGVAAPPRRAPFKGSAAARSVL-L 610
            ||.:..|        ||||...|...::| |..|    :.:|....|   .|.:....|:||| |
  Fly   140 GDVIYATEDRKVEIECVSVGGKPAAEITWIDGLGNVLTDNIEYTVIP---LPDQRRFTAKSVLRL 201

Human   611 QVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFL-------------------GEQVLVV 656
            ......|....:|:|.:...|...|:..|:.|.|.|:..                   |..|.:.
  Fly   202 TPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMS 266

Human   657 TA---VEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRA-DDGLY 717
            |.   ||..:..|.....|||:...:.|......:  .||.:..::      :.||||. .|.:.
  Fly   267 TGSRIVEHSQVRLECRADANPSDVRYRWFINDEPI--IGGQKTEMV------IRNVTRKFHDAIV 323

Human   718 QLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDE 782
            :...|||.|.:|....||:.|||:.|......|.:||..|.:.|.||:|| .|.:. |.:...|.
  Fly   324 KCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNP-QPEIV-WIQHPSDR 386

Human   783 EDQSLDDME-KISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPL 846
            ...:..::. .:|....||   ::.|....|..:...|..|          .::.:|.:  .:..
  Fly   387 VVGTSTNLTFSVSNETAGR---YYCKANVPGYAEISADAYV----------YLKGSPAI--GSQR 436

Human   847 TKVAAAGDSTSSATLHCRARGVPNI-VFTWTKNGVPLDLQDPRYTEHTYH------QGGVHSSLL 904
            |:....||   :|.:.|.|..||.. ..:||.||..:..:    :.|.|.      .|||.|:|
  Fly   437 TQYGLVGD---TARIECFASSVPRARHVSWTFNGQEISSE----SGHDYSILVDAVPGGVKSTL- 493

Human   905 TIANVSAAQDYALFTCTATNALGSDQTNIQL-----VSISRPDPPSGLKVVS------------- 951
             |...|.|..|..:.||..|..|:|...|||     ||:.. ....|:.||:
  Fly   494 -IIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLM-TIVGGISVVAFLLVLTILVVVYI 556

Human   952 -------------LTPHSV----GLEWK--PG------------FDGGLPQRFCIRYEALGTPGF 985
                         ::.|.:    |:..|  ||            ..||        |...|....
  Fly   557 KCKKRTKLPPADVISEHQITKNGGVSCKLEPGDRTSNYSDLKVDISGG--------YVPYGDYST 613

Human   986 HYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLP 1050
            ||..  |||..|...|             .||  |.|.:.....|..:.   |.|...:...|..
  Fly   614 HYSP--PPQYLTTCST-------------KSN--GSSTIMQNNHQNQLQ---LQQQQQQSHHQHH 658

Human  1051 TEPPSGPSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGIS--EKTEAGSEEDRVRNE 1113
            |:..:       ||:.|    |...|..|..|.::..|.:|: ..|:.  :.|.|         .
  Fly   659 TQTTT-------LPMTF----LTNSSGGSLTGSIIGSREIRQ-DNGLPSLQSTTA---------S 702

Human  1114 YEESQWTGERDTQSSTVSTTE----------------------AEPYYRSLRDFSPQLPP 1151
            ...|...|....||:|.:||.                      ..||.||..  |..|||
  Fly   703 VVSSSPNGSCSNQSTTAATTTTTHVVVPSSMALSVDPRYSAIYGNPYLRSSN--SSLLPP 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPHS1	NP_004637.1	V-set	38..119	CDD:284989
		IG_like	38..113	CDD:214653
		C2-set_2	141..228	CDD:285423
		Ig	240..321	CDD:299845
		IG_like	254..336	CDD:214653
		Ig	345..424	CDD:299845
		Ig	445..530	CDD:299845	25/85 (29%)
		I-set	446..541	CDD:254352	29/103 (28%)
		Ig	549..632	CDD:299845	23/96 (24%)
		IG_like	558..642	CDD:214653	25/97 (26%)
		I-set	646..736	CDD:254352	24/112 (21%)
		Ig	662..736	CDD:299845	18/74 (24%)
		Ig_3	739..820	CDD:290638	20/81 (25%)
		IG_like	748..821	CDD:214653	18/73 (25%)
		Ig8_hNephrin_like	834..942	CDD:143250	34/119 (29%)
		IG_like	845..935	CDD:214653	29/96 (30%)
		fn3	942..1023	CDD:278470	22/124 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		9/59 (15%)
		Binds to NPHS2	1160..1241
rst	NP_001284835.1	IG_like	34..130	CDD:214653	29/101 (29%)
		Ig	42..114	CDD:299845	22/77 (29%)
		C2-set_2	135..225	CDD:285423	23/92 (25%)
		Ig_3	265..329	CDD:290638	15/71 (21%)
		I-set	346..420	CDD:254352	19/78 (24%)
		Ig	360..425	CDD:299845	17/79 (22%)
		Ig5_KIRREL3-like	428..524	CDD:143235	31/106 (29%)
		IG_like	435..524	CDD:214653	30/97 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920