DRSC/TRiP Functional Genomics Resources

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Protein Alignment NPHS1 and nphs1

DIOPT Version :10

Sequence 1:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens
Sequence 2:XP_031761552.1 Gene:nphs1 / 100494620 XenbaseID:XB-GENE-487811 Length:1236 Species:Xenopus tropicalis


Alignment Length:1273 Identity:554/1273 - (43%)
Similarity:753/1273 - (59%) Gaps:97/1273 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    16 LLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGF 80
            :|.||:      .:..:.|...|:|:|||:|::..|.|.|......|||.|:|||||||..||||
 Frog    14 ILREGV------TAKQQVFRVQPDNITVVQGSTALLSCEVEHGTGMVQWEKNGLLLGPDRNIPGF 72

Human    81 PRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTP--- 142
            .||.:.|||.:||::|.||..:|.|||||.|||||||:...::|...::::|:|||    .|   
 Frog    73 LRYSMTGDPHKGEYNLRIERSELDDDAEYHCQVGRSEVSLGIISRTALINVLIPPK----APTFE 133

Human   143 --EAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVT 205
              .||:.||||.|.||.|.|.:.|||||..:||..||..:|..|:: |.||:.||......|:|.
 Frog   134 EYAAGSRVTWVYGVEYTVTCQATDAKPAAALTIKKSGLEVSGDSSS-NPGSRDKLENTAMVAKVI 197

Human   206 PRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGG 270
            |:||||.:||.|.|.:|||:.||..|||:||||||..|:||  |.....|:||::|:|.|::..|
 Frog   198 PQSSDNGKLLTCLALNPALQTPITVSFTMNVLFPPNAPIIE--GYIGPSVKAGETLKLICISLSG 260

Human   271 NPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQ 335
            ||||||||.||...|||.|.|:.....:||.|.:.::|.|:.|.:||||.|.|:..|.:..|.|.
 Frog   261 NPLATLQWSKNDDVVSTRWETDEVVRASRSHLTLNIKPADNMAVVSCEAVNHVTPETLKTSIILN 325

Human   336 VTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMS 400
            |.|.|:.:.||||:|..|..|:|.||.:.:|.|.|.:|||||.::|:....|:.|.:|||.::||
 Frog   326 VVFLPTEVTILGSSSGPEKSNLTFSCFTAASNPPVQIRWWLGPKELVNTIVTISDAVHGGKVTMS 390

Human   401 NLTFLARREDNGLTLTCEAFSEA--FTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRL 463
            |||..|.||::|:.||||||:||  :||   ..|:.|:|:||.|.:|||.||..:..||||.|::
 Frog   391 NLTMEALREEHGMALTCEAFNEAILYTK---SNSVTLSVQYPPQNVWIEAPPADKFFRAGTSVKM 452

Human   464 VCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC 528
            .|.:.||||.|.|.|.||:::::.            ||...||...::|:.::|.||||.|.:.|
 Frog   453 TCFSSGGNPPPRLTWIKDTKSLSG------------GSQIHSGKIVTKEITIITVPSDNMATYRC 505

Human   529 KAGQ------LSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERL 587
            .|..      |:|||:|.||||..:|.|:::|...|.|..:.||||:.||||...:||.|:||:|
 Frog   506 NASNIGKTPALTASTKLKVQFPAIDVNIISSAKEYRRGSTIILTCVTGSSNPASTISWVKDGEQL 570

Human   588 EGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQ 652
            :......:.:.:.|.:::..|.|:.:|:|:|:||:|.|.|:.|.|.|::||:||:|:.||||.:|
 Frog   571 KAQDLGRKPSLYGGISSSSRVTLKAASKDNGRRVSCEAFSSVLNEAVNTFYKLNILFPPEFLDDQ 635

Human   653 VLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLY 717
            ..||.|||.|.||:||.|.|||....:.|:..|.:|...|..||.:...|||.:|||:|||.|:|
 Frog   636 PAVVQAVEHGAALIPVRVRANPPQINYTWSLWGEKLIRDGAYRHHLRGEGALEIWNVSRADSGVY 700

Human   718 QLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDE 782
            .:.|.|.||.....:||||.|:||||:|.| |||::|...:|.||.||||....||.|..||::|
 Frog   701 NVTCVNKEGKNSIVIRLDVQYSPTIRSLGD-TEVDLGSDAEIACTADANPATDSMFQWRWLGDEE 764

Human   783 EDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLT 847
            .|  |..:|:...|..|||.|..||...||.|:|.||||:.|..:...||:|||.|.:.....|:
 Frog   765 RD--LSALERKVDGVIGRLVIREAKRTDAGRYECTVDNGIPPSIKADARLIVRFKPDIHKGVHLS 827

Human   848 KVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAA 912
            |||..||..|.|.|.|:|.|:|::.|:|.||||.|||:||||:|.|:|:..||:|.|.|:||||.
 Frog   828 KVAVPGDGKSVAALVCKAEGIPSVAFSWAKNGVSLDLKDPRYSEKTFHELSVHTSTLVISNVSAV 892

Human   913 QDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRY 977
            :|||||||||||.||.|...|||||.|||||||||:|:..|.:||.|:|..|||||..|:|.:||
 Frog   893 KDYALFTCTATNTLGVDSFTIQLVSTSRPDPPSGLRVIGFTHNSVTLQWSAGFDGGAEQKFRVRY 957

Human   978 EALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKG----------TQLP 1032
            ...||....||||.|||.|.||:|||:.||.|...:.|.||||:|..||:|          |.||
 Frog   958 RWPGTDSHMYVDVFPPQETVFTITGLKGSTAYNFSVNAINALGESDYADQGAVVSVTTKETTLLP 1022

Human  1033 ITTPGLHQPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGI 1097
            :.|   .||:..|..:....||.      :|..:.|.|.|||:|||:.:|.::  :|.|..::| 
 Frog  1023 VPT---QQPTRAPTAEALEWPPY------ILAAVCAGGALLLVSNAAFIGCLV--KRSRDKSQG- 1075

Human  1098 SEKTEAGSEEDRVRNEYEESQWTGER-------DTQSSTVST------TEAEPYYRSLRDFSPQL 1149
            .|..:....:.|..|||.:.:.....       |:.|.|.|:      :|:..||..:||:.|.|
 Frog  1076 GEGVKKDESQQRALNEYGDGELINTHAKKTLLIDSGSETGSSLYQDSASESGIYYYPVRDYRPSL 1140

Human  1150 PPTQEEVSYSRGFTG---------EDEDMAFPGHLYDEVERTYPPSGAWGPLYDEVQMGPWDLHW 1205
            .| |.||. .||.:|         ||......||.|:|| ..||.|........|......:..|
 Frog  1141 SP-QYEVP-ERGESGIRGWEEGGYEDWYSTSEGHEYEEV-GDYPQSSRVRWQNRETANQGREASW 1202

Human  1206 PEDTYQDP--RGIYDQVAGDLDTLEPDSLPFELRGHLV 1241
            .|  ||||  ..|||:  .|:...:....|:..||.||
 Frog  1203 AE--YQDPGRLRIYDE--ADVTLSDVYETPYGGRGQLV 1236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPHS1NP_004637.1 V-set 38..119 CDD:462230 47/80 (59%)
C2-set_2 141..228 CDD:400489 42/91 (46%)
Ig strand B 156..160 CDD:409353 2/3 (67%)
Ig strand C 170..174 CDD:409353 1/3 (33%)
Ig strand E 200..204 CDD:409353 1/3 (33%)
Ig strand F 214..219 CDD:409353 3/4 (75%)
Ig strand G 229..232 CDD:409353 0/2 (0%)
Ig 237..336 CDD:472250 45/98 (46%)
Ig strand B 261..265 CDD:409353 2/3 (67%)
Ig strand C 275..279 CDD:409353 3/3 (100%)
Ig strand E 300..304 CDD:409353 2/3 (67%)
Ig strand F 314..319 CDD:409353 2/4 (50%)
Ig strand G 332..335 CDD:409353 1/2 (50%)
Ig 345..424 CDD:472250 41/80 (51%)
Ig strand B 357..361 CDD:409353 1/3 (33%)
Ig strand C 371..375 CDD:409353 1/3 (33%)
Ig strand E 400..404 CDD:409353 3/3 (100%)
Ig strand F 414..419 CDD:409353 3/4 (75%)
Ig strand G 430..433 CDD:409353 0/2 (0%)
Ig 446..541 CDD:472250 37/100 (37%)
Ig strand B 461..465 CDD:409353 1/3 (33%)
Ig strand C 475..479 CDD:409353 1/3 (33%)
Ig strand E 510..515 CDD:409353 1/4 (25%)
Ig strand F 525..530 CDD:409353 1/4 (25%)
Ig 549..632 CDD:472250 30/82 (37%)
Ig strand B 563..567 CDD:409353 1/3 (33%)
Ig strand C 577..581 CDD:409353 1/3 (33%)
Ig strand E 606..610 CDD:409353 1/3 (33%)
Ig strand F 620..625 CDD:409353 3/4 (75%)
Ig strand G 635..638 CDD:409353 0/2 (0%)
Ig 646..736 CDD:472250 42/89 (47%)
Ig strand B 664..668 CDD:409353 2/3 (67%)
Ig strand C 678..682 CDD:409353 0/3 (0%)
Ig strand E 702..706 CDD:409353 3/3 (100%)
Ig strand F 716..721 CDD:409353 1/4 (25%)
Ig strand G 729..732 CDD:409353 0/2 (0%)
Ig_3 740..820 CDD:464046 38/79 (48%)
IgC1_hNephrin_like 834..942 CDD:143250 63/107 (59%)
putative Ig strand A 839..844 CDD:143250 0/4 (0%)
putative Ig strand B 859..866 CDD:143250 3/6 (50%)
putative Ig strand C 870..876 CDD:143250 1/5 (20%)
putative Ig strand C' 879..881 CDD:143250 1/1 (100%)
putative Ig strand D 888..891 CDD:143250 2/2 (100%)
putative Ig strand E 898..906 CDD:143250 4/7 (57%)
putative Ig strand F 917..924 CDD:143250 6/6 (100%)
putative Ig strand G 939..942 CDD:143250 2/2 (100%)
FN3 941..1022 CDD:238020 45/80 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 12/41 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137 10/50 (20%)
Binds to NPHS2 1160..1241 27/91 (30%)
nphs1XP_031761552.1 Ig 25..105 CDD:472250 42/79 (53%)
Ig strand B 41..45 CDD:409353 1/3 (33%)
Ig strand C 53..57 CDD:409353 2/3 (67%)
Ig strand F 100..106 CDD:409353 4/5 (80%)
Ig strand G 116..119 CDD:409353 1/2 (50%)
Ig 138..228 CDD:472250 45/90 (50%)
Ig strand B 149..153 CDD:409353 2/3 (67%)
Ig strand C 163..167 CDD:409353 1/3 (33%)
Ig strand E 192..196 CDD:409353 1/3 (33%)
Ig strand F 206..211 CDD:409353 3/4 (75%)
Ig strand G 221..224 CDD:409353 0/2 (0%)
Ig 229..326 CDD:472250 45/98 (46%)
Ig strand B 251..255 CDD:409353 2/3 (67%)
Ig strand C 265..269 CDD:409353 3/3 (100%)
Ig strand E 290..294 CDD:409353 2/3 (67%)
Ig strand F 304..310 CDD:409353 3/5 (60%)
Ig strand G 319..322 CDD:409353 0/2 (0%)
Ig 332..413 CDD:472250 39/80 (49%)
Ig strand B 347..351 CDD:409353 1/3 (33%)
Ig strand C 361..365 CDD:409353 1/3 (33%)
Ig strand E 390..394 CDD:409353 3/3 (100%)
Ig strand F 404..409 CDD:409353 3/4 (75%)
Ig_3 429..509 CDD:464046 35/91 (38%)
Ig 541..618 CDD:472250 29/76 (38%)
Ig strand B 546..550 CDD:409353 1/3 (33%)
Ig strand C 560..564 CDD:409353 1/3 (33%)
Ig strand E 589..593 CDD:409353 1/3 (33%)
Ig strand F 603..612 CDD:409353 5/8 (63%)
Ig <652..719 CDD:472250 27/66 (41%)
Ig strand C 659..665 CDD:409353 0/5 (0%)
Ig strand E 686..689 CDD:409353 2/2 (100%)
Ig strand F 699..704 CDD:409353 1/4 (25%)
Ig strand G 712..715 CDD:409353 0/2 (0%)
Ig_3 723..800 CDD:464046 38/79 (48%)
Ig 814..922 CDD:472250 63/107 (59%)
Ig strand B 839..843 CDD:143250 2/3 (67%)
Ig strand C 852..856 CDD:143250 1/3 (33%)
Ig strand E 882..886 CDD:143250 2/3 (67%)
FN3 <895..1180 CDD:442628 121/299 (40%)
Ig strand F 897..902 CDD:143250 4/4 (100%)
Ig strand G 919..922 CDD:143250 2/2 (100%)
FN3 921..1015 CDD:238020 49/93 (53%)

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