Protein Alignment NPC1 and Ptr

DIOPT Version :10

• Sequence 1: XP_005258334.1
• Gene: NPC1 / 4864
• HGNCID: 7897
• Length: 1303
• Species: Homo sapiens
• Sequence 2: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Alignment Length: 1031
• Identity: 224/1031 - (21%)
• Similarity: 403/1031 - (39%)
• Gaps: 285/1031 - (27%)

Human   339 SCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 403
            ||.|..       |.:.|...|....::||..|...::....|.:|...::...:|..|:|..:.
  Fly     6 SCVDKT-------LNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAG 63

Human   404 QARLEKEYFDQHF----------------GPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPL 452
            :.:.|:...:|:|                |.|.|   :|:.....|:::.:.
  Fly    64 EGKTERAIVEQYFKVNYTHRFNVGRITRPGRFGR---VIVITKDGDENMIRR------------- 112

Human   453 DIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKG 517
              ::..::..|...|:|.|.:||.:|.|.:|.|    :.:...|        |:|....||....
  Fly   113 --EVFQELRQLDNIIQNATTTYDGDTYTYKDNC----ARWENEC--------FENDILNLDALMD 163

Human   518 DDFFVYADYHTHFLYCVRAPASLNDT-SLLHDPCLGTFGGPVFPWLVLGG--YDDQNYNNATALV 579
            |               :.| ..||.| ..:.:|.  |:...:|| :..||  ..:.||      |
  Fly   164 D---------------IEA-GQLNLTFPFMFNPV--TWDAHLFP-VFFGGTKLTEDNY------V 203

Human   580 ITFP-VNNYYNDTEKLQRAQA----WEKEFINFVKNYKN----PNLTISFTAERSIEDELNRESD 635
            |:.| :...|..|...:|..|    ||:.|:..|.|.:|    .::::|:.|.|:::.||.:.:.
  Fly   204 ISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTK 268

Human   636 SDVFTVVISYAIMFLYISL------ALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSY 694
                |||..::..||.:.|      .:|.       .|.||..||:.|.:..:.:...:.|:..|
  Fly   269 ----TVVPYFSSTFLLMGLFSIITCMMGD-------AVRSKPFLGLMGNVSAIMATLAAFGLAMY 322

Human   695 IGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSE 759
            .|:....|.: ..|||::.:|:|:.|:::..::|.:...  .:.:::|.::.|.|.|:.::|.::
  Fly   323 CGIEFIGINL-AAPFLMIGIGIDDTFVMLAGWRRTKAKM--PVAERMGLMMSEAAVSITITSVTD 384

Human   760 TVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC------- 817
            .::|.:|.:|...:|..|..::..||...||..||.|.:.:.:...|:.||...||.|
  Fly   385 FISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSV 449

Human   818 -------------VRGAEDGTS----VQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSF 865
                         :.|..|...    :...:..|..|||:..:.::...|.:.|:|..|...|..
  Fly   450 AIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVG 514

Human   866 SIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMG 930
            :...:.::..||::.....:|||.|::|.....|....|              .:.|.::.|.:.
  Fly   515 ACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFP--------------YRMQVIIAGPLN 565

Human   931 CNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVR 995
             .:|.|||:                                   :|:|:|....:.|.|
  Fly   566 -YSDPLVQE-----------------------------------QVENLTSTLEHTSYV------ 588

Human   996 CRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHT 1060
                    ..|.....::|....||..|                 |.||              :.
  Fly   589 --------TSRRYTESWLRSFLSFLERN-----------------NELL--------------NV 614

Human  1061 VLQTSADFIDALK-------------------KARLIAS-------NVTET-------------- 1085
            .:.....||||:|                   :.::|||       |:|:|
  Fly   615 TVDDEQTFIDAVKEHWLFPGNPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQIC 679

Human  1086 --MGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLG---CELWSAVIMC 1145
              ..:|.|.:.  ||   :||::|:..:...::..:.:....:.:::.|.:.   |.||.|.
  Fly   680 KDSPLNASIFH--PY---FVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAF--- 736

Human  1146 ATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAH 1210
             ::..:.:.:.|.|.||.::|:::|::||:|..|.||:|.:||...:..|.|.|...|..|||..
  Fly   737 -SVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHS 800

Human  1211 MGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1266
            :|..:..|.:.|.. |||.|..|:|.||.:| |:|...::..||.|||..||||||
  Fly   801 LGLPIIQGSSSTIL-GIVALLLAQSYIFLVF-FKMVFLVIFFGAMHGLFLLPVLLS 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPC1	XP_005258334.1	2A060601	25..1268	CDD:273337	224/1031 (22%)
Ptr	NP_610209.2	Patched	53..845	CDD:308203	204/966 (21%)