Protein Alignment Act87E and ACTL6B

DIOPT Version :10

• Sequence 1: NP_477091.1
• Gene: Act87E / 48632
• FlyBaseID: FBgn0000046
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 160/428 - (37%)
• Similarity: 230/428 - (53%)
• Gaps: 67/428 - (15%)

  Fly     4 DEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVG--RPRHQGVMVGMGQKDS------------Y 54
            |||.|||.|.||...:||:||:|.|:|.||:.||  .....|.:...|.|:.            :
Human     9 DEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALH 73

  Fly    55 V---GDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKAN 116
            |   |.|..|         |:::|:|.:|:....|..||:...::..|..||||::|||.|.:|.
Human    74 VPRDGAEVMS---------PLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAK 129

  Fly   117 REKMTQIMFETFNAPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT--VPIYEGYALPHAILRL 179
            |||:|::|||.:|.||.::...|||:.:|:||:||:||||  |.:||  :|:::||.|...|::.
Human   130 REKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDS--GATHTTAIPVHDGYVLQQGIVKS 192

  Fly   180 DLAGRDLTDYLMKILTERGYSFT---TTAEREIVRD-------IKEKLCYVA------------L 222
            .|||..::....::..|......   ..|.:|.||:       .||||..|:            .
Human   193 PLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQ 257

  Fly   223 DFEQEMATAAASTSLEK--------SYELPDGQVITIGNERFRCPESLFQPS----FLGMESCGI 275
            ||:..:...:.|...|:        .||:|:|.....|.||.|.||.||.||    ..|....|:
Human   258 DFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGV 322

  Fly   276 HETVYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITALAPSTIKIKIIA---PPERK 337
            ...|..||..||:|||..||.:::::||.|:..|..||:.:|::...|.::::|:||   ..|||
Human   323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERK 387

  Fly   338 YSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKC 375
            :|.||||||||||.||||||||||||:|.|...|.|||
Human   388 FSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Act87E	NP_477091.1	ASKHA_NBD_actin	7..371	CDD:466823	153/419 (37%)
ACTL6B	NP_057272.1	ASKHA_NBD_Arp4_ACTL6-like	8..417	CDD:466846	155/418 (37%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		8/42 (19%)