DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act87E and POTEA

DIOPT Version :9

Sequence 1:	NP_001287314.1	Gene:	Act87E / 48632	FlyBaseID:	FBgn0000046	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_024302914.1	Gene:	POTEA / 340441	HGNCID:	33893	Length:	559	Species:	Homo sapiens

Alignment Length:	236	Identity:	50/236 - (21%)
Similarity:	83/236 - (35%)	Gaps:	65/236 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 IEHGIITNWDDM--EKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAMY 134
            ::||...|..||  ....|:..|||.::..:  .:||..|.:..| |:..:|.::..........
Human   152 LQHGTDPNLPDMYGNTALHYAVYNEDKLMAK--TLLLYGADIESK-NKGGLTPLLLAVHGQKQRM 213

  Fly   135 V--AIQAVLSLYASGR--TTGIVLDSGDGVSHTVPIYEGYALPHAILR--LDLAGRDLTDYLMKI 193
            |  .|:...:|.|..|  .|.::|....|.:..|.:         :|:  :|:..:|:
Human   214 VKFLIKKKANLNALDRFGRTALILAVRCGSASIVSL---------LLQQNIDVFSQDV------- 262

  Fly   194 LTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRC 258
                   |..|||...|......:|.:..|:              |..::|:.   :.||..
Human   263 -------FGQTAEDYAVSSHHSIICQLLSDY--------------KENQMPNN---SSGNSN--- 300

  Fly   259 PE------SLFQPSFLGMESCGIHETVYNSIMKCDVDIRKD 293
            ||      |..:|..|.......||.|..     :.||.||
Human   301 PEQDLKLTSEEEPQRLKGSENSQHEKVTQ-----EPDINKD 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act87E	NP_001287314.1	PTZ00281	1..376	CDD:173506	50/236 (21%)
POTEA	XP_024302914.1	ANK	93..218	CDD:238125	16/68 (24%)
		ANK repeat	100..129	CDD:293786
		ANK repeat	133..162	CDD:293786	3/9 (33%)
		ANK	159..283	CDD:238125	31/149 (21%)
		ANK repeat	164..195	CDD:293786	8/33 (24%)
		ANK repeat	197..228	CDD:293786	5/30 (17%)
		ANK repeat	230..261	CDD:293786	6/39 (15%)
		SMC_N	<302..538	CDD:330553	11/40 (28%)
		CCDC144C	452..>559	CDD:317340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910