DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Act87E and Actl9b

DIOPT Version :9

Sequence 1:	NP_001287314.1	Gene:	Act87E / 48632	FlyBaseID:	FBgn0000046	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001013915.1	Gene:	Actl9b / 292516	RGDID:	1359476	Length:	411	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	154/375 - (41%)
Similarity:	237/375 - (63%)	Gaps:	11/375 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVG-RPRHQGVMVGMGQKDSYVGDEAQSKRGILTL 68
            :::.:|:|.|:|:||.||||...|..:..:||| :|:.:..| ...:.:.::| ||...|..|||
  Rat    43 KMSGVVIDMGTGICKMGFAGQTRPTYIVRNIVGCQPKRRTTM-EQPKMEMFIG-EAAHARPELTL 105

  Fly    69 KYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAM 133
            .:|:.:||:.:|:..|.||.|...|:||:..::||:|.|:.|.||.:||||:.::.||:.::||:
  Rat   106 MHPVRNGIVVDWEAAEFIWRHILENDLRLDTQDHPLLFTDPPFNPASNREKLVEVAFESLHSPAI 170

  Fly   134 YVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLM-KILTER 197
            |||.|:|||:||:||..|:|:|:|.|||:|||:::||.||..|.|:||||..||.:|. |||..
  Rat   171 YVASQSVLSVYANGRVNGLVVDTGHGVSYTVPVFQGYNLPSGIQRMDLAGHYLTKFLAEKILRS- 234

  Fly   198 GYSFTTTAE-REIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPES 261
              ||....| .:.:.:||::.|||||||::|.  ........:..:|||||:||:|.|.|:|||.
  Rat   235 --SFAVKKEDMDTMENIKQQYCYVALDFQKEQ--GRPDEKFRRCLKLPDGQMITVGKELFQCPEL 295

  Fly   262 LFQ-PSFLGMESCGIHETVYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITALAPST 325
            ||. |...|..|.|:...|.:|:.....::|.|:..|:::.||::::.|...|.:.|:.......
  Rat   296 LFHPPDTSGPSSLGLPSMVEHSLSTVPQELRADMEQNVLLCGGSSLFTGFEGRFKTELLRRLGPE 360

  Fly   326 IKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKC 375
            ..:.::|...|..||||||||||||..||..|:.:::|:|.||.||.|||
  Rat   361 AHVVVVAQANRNLSVWIGGSILASLCAFQTRWVLREQYEEHGPDIVLRKC 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act87E	NP_001287314.1	PTZ00281	1..376	CDD:173506	154/375 (41%)
Actl9b	NP_001013915.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		NBD_sugar-kinase_HSP70_actin	45..410	CDD:302596	152/371 (41%)
		Actin	47..411	CDD:278451	154/371 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010