DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act87E and Actl7a

DIOPT Version :9

Sequence 1:	NP_001287314.1	Gene:	Act87E / 48632	FlyBaseID:	FBgn0000046	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_033741.1	Gene:	Actl7a / 11470	MGIID:	1343051	Length:	440	Species:	Mus musculus

Alignment Length:	370	Identity:	163/370 - (44%)
Similarity:	238/370 - (64%)	Gaps:	6/370 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPI 72
            |:|||.|:|.||.||||...|.....:.||:|..:....|..:|:::||.|..:....|.|..|:
Mouse    76 AVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGHELFNPDIHLKLVNPL 140

  Fly    73 EHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAMYVAI 137
            .||||.:||.::.||.:.|..|:::|||||.||:::.||:|..||||..:::|||||.|||::|.
Mouse   141 RHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAY 205

  Fly   138 QAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFT 202
            |:.||:|:.|||:|:|::.|.|||:.|||||||.||....|||.||.|||.|||.::...|..|:
Mouse   206 QSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMNLMNNSGKHFS 270

  Fly   203 TTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPESLFQPSF 267
            .. ...||.|||.:.|:||||..:|....|....:.  |.||||:.|.:|.|||.|.|..|:||.
Mouse   271 ED-HLGIVEDIKTRCCFVALDPIEEKKIPAPEHEIH--YTLPDGKEIRLGQERFLCSEMFFKPSL 332

  Fly   268 LGMESCGIHETVYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITALAPS-TIKIKII 331
            :.....|:|....:.:.|||:.:::||..||::.||:||..|..:|:|||::::.|: |.::.::
Mouse   333 IKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTPQVNVL 397

  Fly   332 APPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF 376
              |||..:||.||||||||..||.:|:.:.||:|.||..::|:||
Mouse   398 --PERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act87E	NP_001287314.1	PTZ00281	1..376	CDD:173506	161/368 (44%)
Actl7a	NP_033741.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		ACTL7A_N	6..70	CDD:293445
		Required for interaction with TES. /evidence=ECO:0000250	36..56
		NBD_sugar-kinase_HSP70_actin	72..440	CDD:302596	161/368 (44%)
		ACTIN	74..440	CDD:214592	161/368 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910