DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Bc and HSPA9

DIOPT Version :9

Sequence 1:NP_650209.1 Gene:Hsp70Bc / 48583 FlyBaseID:FBgn0013279 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_004125.3 Gene:HSPA9 / 3313 HGNCID:5244 Length:679 Species:Homo sapiens


Alignment Length:628 Identity:314/628 - (50%)
Similarity:425/628 - (67%) Gaps:32/628 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|.|||.|...||.||.:..
Human    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEA 130
            ||||||:||||::.:|:|:.|||:|  |:|   ...||..|  |.::|.:|.:.||.|||||||.
Human   121 KRLIGRRYDDPEVQKDIKNVPFKIVRASNG---DAWVEAHG--KLYSPSQIGAFVLMKMKETAEN 180

  Fly   131 YLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIF 195
            |||.:..:|||||||||||||||||||||.|:||||||:|||||||||||||||:  .::.:.::
Human   181 YLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVY 243

  Fly   196 DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRR 260
            ||||||||:|||.|.:| :|||:||.|||.|||||||..|:.|:.:||||:...||..:..||:|
Human   244 DLGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQR 307

  Fly   261 LRTAAERAKRTLSSSTEATIEIDALFEG----QDFYTKVSRARFEELCADLFRNTLQPVEKALND 321
            :|.|||:||..||||.:..|.:..|...    :....|::||:||.:..||.|.|:.|.:||:.|
Human   308 VREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQD 372

  Fly   322 AKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKI 386
            |::.|..|.:::||||.||:||||..:|:.| |:..:.::|||||||.|||:|..:|:||    :
Human   373 AEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----V 432

  Fly   387 QDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDN 451
            .||||:||.||||||||.|||.||||.||..||.|:::.|||.:|.|..|.|:|.:|||.|..||
Human   433 TDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDN 497

  Fly   452 NALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRM 516
            ..||.|.|.|||||||||||||||||:|||||::||||:..||:.:.|.|:: .|.||:.:|:.|
Human   498 KLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDIENM 561

  Fly   517 VNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVE----QAPAGKLDEADK-NSVLDKCNETIR 576
            |..|||||:||.:.::|:.:.|..|..:.:.:..:|    |.||   ||.:| ...:.|..|.:.
Human   562 VKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA---DECNKLKEEISKMRELLA 623

  Fly   577 WLDSNTTAEKEEFDHKMEELTRHCSPIMTK---MHQQGAGAAG 616
            ..||.|.....:....:::.:.....:..|   ..::|:|::|
Human   624 RKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSG 666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70BcNP_650209.1 PTZ00009 2..641 CDD:240227 314/628 (50%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 205/381 (54%)
HSPA9NP_004125.3 Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583 1..432 208/388 (54%)
dnaK 52..673 CDD:234715 314/628 (50%)
Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583 432..679 106/239 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..679 3/11 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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