Protein Alignment Hsp70Bc and HSPA1A

DIOPT Version :9

• Sequence 1: NP_650209.1
• Gene: Hsp70Bc / 48583
• FlyBaseID: FBgn0013279
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_005336.3
• Gene: HSPA1A / 3303
• HGNCID: 5232
• Length: 641
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 486/647 - (75%)
• Similarity: 557/647 - (86%)
• Gaps: 19/647 - (2%)

  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67
            |||||||||||||||:|||||||||||||||||||||||||:||||||.||||||:||:||||||
Human     6 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDA 70

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            |||||||:.||.:..|||||||:|::||.|||:.|.||||:|.|.||||||||||||||.|||||
Human    71 KRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYL 135

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            |..:|:|||||||||||||||||||||.|||||||||||||||||:|||||:..|||||||||||
Human   136 GYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDL 200

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLR 262
            |||||||||||||:| :|||::|||||||||||||||||.|..||||||:|||:..|.||:||||
Human   201 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLR 264

  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327
            ||.|||||||||||:|::|||:||||.||||.::||||||||:||||:||:||||||.|||:||.
Human   265 TACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKA 329

  Fly   328 QIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392
            ||||:|||||||||||||.|||:||:|::||.|||||||||||||||||||.||:|..:||:||:
Human   330 QIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLL 394

  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTF 457
            ||||||||:||||||||.||:||..||.|||:.|:|||||||||.|||||||||||||||.||.|
Human   395 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRF 459

  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522
            :|||||||||||||||||||:||||||||:|.:.|||||..|||.|||||||:.||:|||.||||
Human   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEK 524

  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQSVE-QAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEK 586
            |..|||..|:|::::||||||.||:|.:|| :...||:.||||..|||||.|.|.|||:||.|||
Human   525 YKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEK 589

  Fly   587 EEFDHKMEELTRHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGY-------SGPTVEEVD 641
            :||:||.:||.:.|:||::.::|    .|||||      .||||..       ||||:||||
Human   590 DEFEHKRKELEQVCNPIISGLYQ----GAGGPG------PGGFGAQGPKGGSGSGPTIEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bc	NP_650209.1	PTZ00009	2..641	CDD:240227	484/645 (75%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	308/375 (82%)
HSPA1A	NP_005336.3	PTZ00009	1..611	CDD:240227	468/605 (77%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		311/380 (82%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		92/114 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..641		15/32 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74294
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	LDO	PTHR19375
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.900